Results 11 to 20 of about 455,075 (302)

Immunotherapy: Reshape the Tumor Immune Microenvironment

Frontiers in Immunology, 2022
Tumor immune microenvironment (TIME) include tumor cells, immune cells, cytokines, etc. The interactions between these components, which are divided into anti-tumor and pro-tumor, determine the trend of anti-tumor immunity. Although the immune system can
Bingzhe LV, Bingzhe LV, Yunpeng Wang, Yunpeng Wang, Dongjiang Ma, Dongjiang Ma, Wei Cheng, Wei Cheng, Jie Liu, Jie Liu, Tao Yong, Tao Yong, Hao Chen, Hao Chen, Chen Wang, Chen Wang   +15 more
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Tumor immune microenvironment lncRNAs [PDF]

Briefings in Bioinformatics, 2021
AbstractLong non-coding ribonucleic acids (RNAs) (lncRNAs) are key players in tumorigenesis and immune responses. The nature of their cell type-specific gene expression and other functional evidence support the idea that lncRNAs have distinct cellular functions in the tumor immune microenvironment (TIME).
Eun-Gyeong Park, Sung-Jin Pyo, Youxi Cui, Sang-Ho Yoon, Jin-Wu Nam   +4 more
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Vascular Microenvironment, Tumor Immunity and Immunotherapy [PDF]

Frontiers in Immunology, 2021
Immunotherapy holds great promise for treating cancer. Nonetheless, T cell-based immunotherapy of solid tumors has remained challenging, largely due to the lack of universal tumor-specific antigens and an immunosuppressive tumor microenvironment (TME) that inhibits lymphocyte infiltration and activation.
Zachary Lamplugh, Yi Fan
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Pyroptosis, metabolism, and tumor immune microenvironment [PDF]

Clinical and Translational Medicine, 2021
AbstractIn response to a wide range of stimulations, host cells activate pyroptosis, a kind of inflammatory cell death which is provoked by the cytosolic sensing of danger signals and pathogen infection. In manipulating the cleavage of gasdermins (GSDMs), researchers have found that GSDM proteins serve as the real executors and the deterministic ...
Tiantian Du, Jie Gao, Peilong Li, Yunshan Wang, Qiuchen Qi, Xiaoyan Liu, Juan Li, Chuanxin Wang, Lutao Du   +8 more
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A comprehensive comparison of circulating tumor cells and breast imaging modalities as screening tools for breast cancer in Chinese women

Frontiers in Oncology, 2022
BackgroundCirculating tumor cells (CTCs) have been recognized as a sensitive biomarker for breast cancer (BC). This study aimed to comprehensively compare CTC with imaging modalities, including ultrasonography, mammography, and contrast-enhanced magnetic
Xuan Shao, Xuan Shao, Xiaoyan Jin, Xiaoyan Jin, Xiaoyan Jin, Zhigang Chen, Zhigang Chen, Zhigang Zhang, Zhigang Zhang, Wuzhen Chen, Wuzhen Chen, Jingxin Jiang, Jingxin Jiang, Zhen Wang, Zhen Wang, Ying Cui, Wan-Hung Fan, Ke Wang, Ke Wang, Xiuyan Yu, Xiuyan Yu, Jian Huang, Jian Huang   +22 more
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Chronic stress induces pulmonary epithelial cells to produce acetylcholine that remodels lung pre-metastatic niche of breast cancer by enhancing NETosis

Journal of Experimental & Clinical Cancer Research, 2023
Background Chronic stress promotes most hallmarks of cancer through impacting the malignant tissues, their microenvironment, immunity, lymphatic flow, etc.
Jun Pan, Leyi Zhang, Xiaomei Wang, Lili Li, Chenghui Yang, Zhen Wang, Ke Su, Xiaoxiao Hu, Yi Zhang, Guohong Ren, Jiahuan Jiang, Peng Li, Jian Huang   +12 more
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Role of Intra- and Extracellular Lipid Signals in Cancer Stemness and Potential Therapeutic Strategy

Frontiers in Pharmacology, 2021
Accumulating evidence showed that cancer stem cells (CSCs) play significant roles in cancer initiation, resistance to therapy, recurrence and metastasis. Cancer stem cells possess the ability of self-renewal and can initiate tumor growth and avoid lethal
Jianming Hu, Jianming Hu, Leyi Zhang, Leyi Zhang, Wuzhen Chen, Wuzhen Chen, Lesang Shen, Lesang Shen, Jingxin Jiang, Jingxin Jiang, Shanshan Sun, Shanshan Sun, Zhigang Chen, Zhigang Chen   +13 more
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Tumor Immune Microenvironment in Gynecologic Cancers

Cancers, 2023
Gynecologic cancers have varying response rates to immunotherapy due to the heterogeneity of each cancer’s molecular biology and features of the tumor immune microenvironment (TIME). This article reviews key features of the TIME and its role in the pathophysiology and treatment of ovarian, endometrial, cervical, vulvar, and vaginal cancer. Knowledge of
Daniel Margul, Camilla Yu, Mariam M. AlHilli   +2 more
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Exploration of prognosis and immunometabolism landscapes in ER+ breast cancer based on a novel lipid metabolism-related signature

Frontiers in Immunology, 2023
IntroductionLipid metabolic reprogramming is gaining attention as a hallmark of cancers. Recent mounting evidence indicates that the malignant behavior of breast cancer (BC) is closely related to lipid metabolism.
Lesang Shen, Lesang Shen, Lesang Shen, Huanhuan Huang, Huanhuan Huang, Huanhuan Huang, Jiaxin Li, Jiaxin Li, Jiaxin Li, Wuzhen Chen, Wuzhen Chen, Wuzhen Chen, Yao Yao, Yao Yao, Yao Yao, Jianming Hu, Jianming Hu, Jianming Hu, Jun Zhou, Fengbo Huang, Chao Ni, Chao Ni, Chao Ni   +22 more
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“γδT Cell-IL17A-Neutrophil” Axis Drives Immunosuppression and Confers Breast Cancer Resistance to High-Dose Anti-VEGFR2 Therapy

Frontiers in Immunology, 2021
Angiogenesis is an essential physiological process and hallmark of cancer. Currently, antiangiogenic therapy, mostly targeting the vascular endothelial growth factor (VEGF)/VEGFR2 signaling axis, is commonly used in the clinic for solid tumors.
Zhigang Zhang, Zhigang Zhang, Chenghui Yang, Lili Li, Lili Li, Ying Zhu, Ke Su, Lingyun Zhai, Zhen Wang, Zhen Wang, Jian Huang, Jian Huang, Jian Huang   +12 more
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