Results 11 to 20 of about 463,193 (304)

Immunotherapy: Reshape the Tumor Immune Microenvironment

Frontiers in Immunology, 2022
Tumor immune microenvironment (TIME) include tumor cells, immune cells, cytokines, etc. The interactions between these components, which are divided into anti-tumor and pro-tumor, determine the trend of anti-tumor immunity. Although the immune system can
Bingzhe LV, Bingzhe LV, Yunpeng Wang, Yunpeng Wang, Dongjiang Ma, Dongjiang Ma, Wei Cheng, Wei Cheng, Jie Liu, Jie Liu, Tao Yong, Tao Yong, Hao Chen, Hao Chen, Chen Wang, Chen Wang   +15 more
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Tumor immune microenvironment lncRNAs [PDF]

Briefings in Bioinformatics, 2021
AbstractLong non-coding ribonucleic acids (RNAs) (lncRNAs) are key players in tumorigenesis and immune responses. The nature of their cell type-specific gene expression and other functional evidence support the idea that lncRNAs have distinct cellular functions in the tumor immune microenvironment (TIME).
Eun-Gyeong Park, Sung-Jin Pyo, Youxi Cui, Sang-Ho Yoon, Jin-Wu Nam   +4 more
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Vascular Microenvironment, Tumor Immunity and Immunotherapy [PDF]

Frontiers in Immunology, 2021
Immunotherapy holds great promise for treating cancer. Nonetheless, T cell-based immunotherapy of solid tumors has remained challenging, largely due to the lack of universal tumor-specific antigens and an immunosuppressive tumor microenvironment (TME) that inhibits lymphocyte infiltration and activation.
Zachary Lamplugh, Yi Fan
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Pyroptosis, metabolism, and tumor immune microenvironment [PDF]

Clinical and Translational Medicine, 2021
AbstractIn response to a wide range of stimulations, host cells activate pyroptosis, a kind of inflammatory cell death which is provoked by the cytosolic sensing of danger signals and pathogen infection. In manipulating the cleavage of gasdermins (GSDMs), researchers have found that GSDM proteins serve as the real executors and the deterministic ...
Tiantian Du, Jie Gao, Peilong Li, Yunshan Wang, Qiuchen Qi, Xiaoyan Liu, Juan Li, Chuanxin Wang, Lutao Du   +8 more
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Tumor Immune Microenvironment in Gynecologic Cancers

Cancers, 2023
Gynecologic cancers have varying response rates to immunotherapy due to the heterogeneity of each cancer’s molecular biology and features of the tumor immune microenvironment (TIME). This article reviews key features of the TIME and its role in the pathophysiology and treatment of ovarian, endometrial, cervical, vulvar, and vaginal cancer. Knowledge of
Daniel Margul, Camilla Yu, Mariam M. AlHilli   +2 more
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Tumor Immune Microenvironment during Epithelial–Mesenchymal Transition [PDF]

Clinical Cancer Research, 2021
Abstract Epithelial–mesenchymal transition (EMT) has been shown to play a critical role in tumor development from initiation to metastasis. EMT could be regarded as a continuum, with intermediate hybrid epithelial and mesenchymal phenotypes having high plasticity. Classical EMT is characterized by the phenotype change of epithelial cells
Mana Taki, Kaoru Abiko, Masayo Ukita, Ryusuke Murakami, Koji Yamanoi, Ken Yamaguchi, Junzo Hamanishi, Tsukasa Baba, Noriomi Matsumura, Masaki Mandai   +9 more
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Tumor immune microenvironment (TIME) to enhance antitumor immunity

European Journal of Medical Research, 2023
AbstractThe tumor microenvironment is a result of dynamic interaction between different cellular and non-cellular components. In its essence it is not a solo performer, but an ensemble of performers that includes cancer cells, fibroblasts, myo-fibroblasts, endothelial cells and immune cells.
Sajin Rajbhandary, Hari Dhakal, Sudip Shrestha   +2 more
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Immune Tumor Microenvironment in Ovarian Cancer Ascites

International Journal of Molecular Sciences, 2022
Ovarian cancer (OC) has a specific type of metastasis, via transcoelomic, and most of the patients are diagnosed at advanced stages with multiple tumors spread within the peritoneal cavity. The role of Malignant Ascites (MA) is to serve as a transporter of tumor cells from the primary location to the peritoneal wall or to the surface of the peritoneal ...
Diana Luísa Almeida-Nunes, Ana Mendes-Frias, Ricardo Silvestre, Ricardo Jorge Dinis-Oliveira, Sara Ricardo   +4 more
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Systemic Immune Dysregulation Correlates With Clinical Features of Early Non-Small Cell Lung Cancer

Frontiers in Immunology, 2022
BackgroundSystemic immune dysregulation correlates with cancer progression. However, the clinical implications of systemic immune dysregulation in early non-small cell lung cancer (NSCLC) remain unclear.MethodsUsing a panel of 9 markers to identify 12 ...
Zhixing Hao, Zhixing Hao, Mingjie Lin, Mingjie Lin, Feng Du, Zhongwei Xin, Zhongwei Xin, Dang Wu, Dang Wu, Qun Yu, Yimin Wu, Zhouyu Zhu, Wenshan Li, Yongyuan Chen, Yongyuan Chen, Xiaoke Chen, Xiaoke Chen, Ying Chai, Shenghang Jin, Shenghang Jin, Pin Wu, Pin Wu   +21 more
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NMI: a potential biomarker for tumor prognosis and immunotherapy

Frontiers in Pharmacology, 2022
N-Myc and STAT Interactor protein (NMI) is an interferon inducible protein participating in various cellular activities, and is widely involved in the process of tumorigenesis and progression.
Teng He, Yinbiao Qiao, Qi Yang, Jie Chen, Yongyuan Chen, Yongyuan Chen, Xiaoke Chen, Xiaoke Chen, Zhixing Hao, Zhixing Hao, Mingjie Lin, Mingjie Lin, Zheyu Shao, Zheyu Shao, Pin Wu, Pin Wu, Feng Xu   +16 more
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