Spatial remodeling of the tumor immune microenvironment in hepatocellular carcinoma with cirrhosis driven by Treg-CD8⁺T cell crosstalk via the SPP1-ITGA4 axis. [PDF]
Xue D +14 more
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This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang +4 more
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Colorectal cancer stem cells crosstalk in tumor immune microenvironment and targeted therapeutic strategies. [PDF]
Duan Y +5 more
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Tumor immune microenvironment and immune phenotypes in PD-L1-tested canine urothelial carcinoma. [PDF]
Muscatello LV +11 more
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TLR8 agonists remodel the tumor immune microenvironment through PF4-dependent T cell recruitment and ancillary mechanisms. [PDF]
Zhou Q +8 more
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PILRA serves as a diagnostic and prognostic biomarker and modulates the tumor immune microenvironment and immunotherapy response in breast cancer. [PDF]
Shi B, Yang Y, Xing L, Chen J.
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Single-cell atlas of the tumor immune microenvironment across syngeneic murine models. [PDF]
Wang J +6 more
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A potential strategy to rebuild the tumor immune microenvironment: PANoptosis. [PDF]
Wu S, Tian B, Pang X, Sui B.
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The Tumor Microenvironment Reprograms Immune Cells
Cellular Reprogramming, 2022Tumor tissue comprises a highly complex network of diverse cell types. The tumor microenvironment (TME) can be mainly subdivided into cancer cells and stromal cell compartments, the latter include different types of immune cells, fibroblasts, endothelial cells, and pericytes.
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Tumor Microenvironment and Immune Escape
Surgical Oncology Clinics of North America, 2007This article describes the multiple escape mechanisms used by tumor cells to avoid T-cell-mediated recognition and destruction. The discussion focuses on escape mechanisms that may result from changes at the level of TA-specific cytotoxic T lymphocytes and tumor cells in the tumor microenvironment.
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