Results 21 to 30 of about 463,193 (304)

Aged neutrophils form mitochondria-dependent vital NETs to promote breast cancer lung metastasis

Journal for ImmunoTherapy of Cancer, 2021
Background Neutrophils-linked premetastatic niche plays a key role in tumor metastasis, but not much is known about the heterogeneity and diverse role of neutrophils in niche formation.
Ke Wang, Jian Huang, Zhen Wang, Haijun Wang, Jun Pan, Jun Yan, Zhigang Zhang, Fang Jia, Lili Li, Chenghui Yang, Fuming Qiu, Xiaoyan Jin, Pin Wu, Shanshan Sun, Ke Su, Leyi Zhang, Xiuyan Yu, Xuan Shao   +17 more
doaj   +1 more source

The ambitious role of anti angiogenesis molecules: Turning a cold tumor into a hot one [PDF]

, 2018
In renal cancer emerging treatment options are becoming available and there is a strong need to combine therapies to reformulate and adjourn clinical practice.
Botticelli, A., Marchetti, P., Nuti, M., Rughetti, A., Zizzari, I. G.   +4 more
core   +1 more source

Construction of a MicroRNA-Based Nomogram for Prediction of Lung Metastasis in Breast Cancer Patients

Frontiers in Genetics, 2021
The lung is one of the most common sites of distant metastasis in breast cancer (BC). Identifying ideal biomarkers to construct a more accurate prediction model than conventional clinical parameters is crucial.
Leyi Zhang, Leyi Zhang, Leyi Zhang, Jun Pan, Jun Pan, Jun Pan, Zhen Wang, Zhen Wang, Zhen Wang, Chenghui Yang, Chenghui Yang, Chenghui Yang, Jian Huang, Jian Huang, Jian Huang   +14 more
doaj   +1 more source

Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]

, 2019
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence, Keenan, Bridget P, Kelley, Robin K   +2 more
core   +2 more sources

Extracellular vesicles in the tumor immune microenvironment

Cancer Letters, 2021
Extracellular vesicles (EVs) have gained significant attention in recent decades as major mediators of intercellular communication that are involved in various essential physiological and pathological processes. They are secreted by almost all cell types and carry bioactive materials, such as proteins, lipids and nucleic acids, that can be transmitted ...
Pei-pei Hou, Hang-zi Chen
openaire   +2 more sources

Molecular Immune Targeted Imaging of Tumor Microenvironment [PDF]

Nanotheranostics, 2022
Novel targeted therapies are rapidly emerging for the treatment of cancer. With the advent of new immune targeting agents, understanding the changes in the tumor microenvironment (TME) is critical. Given the complexity and several cellular mechanisms and factors that play a role in the TME, novel imaging methods to assess and evaluate the dynamic ...
Rakhshandehroo, Taha, Smith, Bryan Ronain, Glockner, Hannah J., Rashidian, Mohammad, Pandit-Taskar, Neeta   +4 more
openaire   +2 more sources

CD62Ldim Neutrophils Specifically Migrate to the Lung and Participate in the Formation of the Pre-Metastatic Niche of Breast Cancer

Frontiers in Oncology, 2020
Lung metastasis is one of the leading causes of death in patients with breast cancer. The mechanism of tumor metastasis remains controversial. Recently, the formation of a pre-metastatic niche has been considered a key factor contributing to breast ...
Zhen Wang, Zhen Wang, Zhen Wang, Chenghui Yang, Chenghui Yang, Chenghui Yang, Lili Li, Lili Li, Lili Li, Zhigang Zhang, Zhigang Zhang, Jun Pan, Jun Pan, Jun Pan, Ke Su, Ke Su, Ke Su, Wuzhen Chen, Wuzhen Chen, Jinfan Li, Fuming Qiu, Fuming Qiu, Jian Huang, Jian Huang, Jian Huang   +24 more
doaj   +1 more source

Multi-Omics Profiling Suggesting Intratumoral Mast Cells as Predictive Index of Breast Cancer Lung Metastasis

Frontiers in Oncology, 2022
Breast cancer lung metastasis has a high mortality rate and lacks effective treatments, for the factors that determine breast cancer lung metastasis are not yet well understood.
Leyi Zhang, Leyi Zhang, Leyi Zhang, Leyi Zhang, Jun Pan, Jun Pan, Jun Pan, Jun Pan, Zhen Wang, Zhen Wang, Zhen Wang, Zhen Wang, Chenghui Yang, Chenghui Yang, Chenghui Yang, Chenghui Yang, Chenghui Yang, Wuzhen Chen, Wuzhen Chen, Wuzhen Chen, Wuzhen Chen, Jingxin Jiang, Jingxin Jiang, Jingxin Jiang, Jingxin Jiang, Zhiyuan Zheng, Zhiyuan Zheng, Zhiyuan Zheng, Zhiyuan Zheng, Fang Jia, Fang Jia, Fang Jia, Fang Jia, Yi Zhang, Yi Zhang, Yi Zhang, Yi Zhang, Jiahuan Jiang, Jiahuan Jiang, Jiahuan Jiang, Jiahuan Jiang, Ke Su, Ke Su, Ke Su, Ke Su, Guohong Ren, Guohong Ren, Guohong Ren, Guohong Ren, Jian Huang, Jian Huang, Jian Huang, Jian Huang   +52 more
doaj   +1 more source

Targeting the tumor microenvironment in colorectal peritoneal metastases

, 2020
Peritoneal metastasis (PM) occurs in approximately one in four colorectal cancer (CRC) patients. The pathophysiology of colorectal PM remains poorly characterized. Also, the efficacy of current treatment modalities, including surgery and intraperitoneal (
Ceelen, Wim, De Wever, Olivier, Heriot, Alexander G., Narasimhan, Vignesh, Ramsay, Robert G.   +4 more
core   +1 more source

Exosomes promote pre-metastatic niche formation in ovarian cancer. [PDF]

, 2019
Ovarian cancer is one of the most common gynecological malignancies. Upon initial diagnosis, the majority of patients present with widespread metastatic growth within the peritoneal cavity. This metastatic growth occurs in stages, with the formation of a
Dean, Dylan C, Duan, Zhenfeng, Feng, Wenlong, Hornicek, Francis J, Shi, Huirong   +4 more
core   +2 more sources