Results 21 to 30 of about 455,075 (302)

Antiangiogenic therapy reverses the immunosuppressive breast cancer microenvironment

Biomarker Research, 2021
Tumor angiogenesis induces local hypoxia and recruits immunosuppressive cells, whereas hypoxia subsequently promotes tumor angiogenesis. Immunotherapy efficacy depends on the accumulation and activity of tumor-infiltrating immune cells (TIICs ...
Wuzhen Chen, Lesang Shen, Jingxin Jiang, Leyi Zhang, Zhigang Zhang, Jun Pan, Chao Ni, Zhigang Chen   +7 more
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Tumor Immune Microenvironment during Epithelial–Mesenchymal Transition [PDF]

Clinical Cancer Research, 2021
Abstract Epithelial–mesenchymal transition (EMT) has been shown to play a critical role in tumor development from initiation to metastasis. EMT could be regarded as a continuum, with intermediate hybrid epithelial and mesenchymal phenotypes having high plasticity. Classical EMT is characterized by the phenotype change of epithelial cells
Mana Taki, Kaoru Abiko, Masayo Ukita, Ryusuke Murakami, Koji Yamanoi, Ken Yamaguchi, Junzo Hamanishi, Tsukasa Baba, Noriomi Matsumura, Masaki Mandai   +9 more
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CD38 Predicts Favorable Prognosis by Enhancing Immune Infiltration and Antitumor Immunity in the Epithelial Ovarian Cancer Microenvironment

Frontiers in Genetics, 2020
The identification of predictive biomarkers and novel targets to optimize immunotherapy strategies for epithelial ovarian cancer (EOC) is urgently needed. CD38 is a multifunctional glycoprotein that acts as an ectoenzyme and immune receptor. However, the
Ying Zhu, Ying Zhu, Zhigang Zhang, Zhigang Zhang, Zhou Jiang, Yang Liu, Yang Liu, Jianwei Zhou   +7 more
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Radiation-induced tumor immune microenvironments and potential targets for combination therapy

Signal Transduction and Targeted Therapy, 2023
As one of the four major means of cancer treatment including surgery, radiotherapy (RT), chemotherapy, immunotherapy, RT can be applied to various cancers as both a radical cancer treatment and an adjuvant treatment before or after surgery.
Siyu Guo, Yihan Yao, Yang Tang, Zengfeng Xin, Dang Wu, Chao Ni, Jian Huang, Qichun Wei, Ting Zhang   +8 more
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Multiomics technologies for comprehensive tumor microenvironment analysis in triple-negative breast cancer under neoadjuvant chemotherapy

Frontiers in Oncology, 2023
Triple-negative breast cancer (TNBC) is one of the most aggressive breast cancer subtypes and is characterized by abundant infiltrating immune cells within the microenvironment. As standard care, chemotherapy remains the fundamental neoadjuvant treatment
Gang Wang, Yao Yao, Yao Yao, Yao Yao, Huanhuan Huang, Huanhuan Huang, Huanhuan Huang, Jun Zhou, Chao Ni, Chao Ni, Chao Ni   +10 more
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Tumor immune microenvironment (TIME) to enhance antitumor immunity

European Journal of Medical Research, 2023
AbstractThe tumor microenvironment is a result of dynamic interaction between different cellular and non-cellular components. In its essence it is not a solo performer, but an ensemble of performers that includes cancer cells, fibroblasts, myo-fibroblasts, endothelial cells and immune cells.
Sajin Rajbhandary, Hari Dhakal, Sudip Shrestha   +2 more
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Systemic Immune Dysregulation Correlates With Clinical Features of Early Non-Small Cell Lung Cancer

Frontiers in Immunology, 2022
BackgroundSystemic immune dysregulation correlates with cancer progression. However, the clinical implications of systemic immune dysregulation in early non-small cell lung cancer (NSCLC) remain unclear.MethodsUsing a panel of 9 markers to identify 12 ...
Zhixing Hao, Zhixing Hao, Mingjie Lin, Mingjie Lin, Feng Du, Zhongwei Xin, Zhongwei Xin, Dang Wu, Dang Wu, Qun Yu, Yimin Wu, Zhouyu Zhu, Wenshan Li, Yongyuan Chen, Yongyuan Chen, Xiaoke Chen, Xiaoke Chen, Ying Chai, Shenghang Jin, Shenghang Jin, Pin Wu, Pin Wu   +21 more
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Immune Tumor Microenvironment in Ovarian Cancer Ascites

International Journal of Molecular Sciences, 2022
Ovarian cancer (OC) has a specific type of metastasis, via transcoelomic, and most of the patients are diagnosed at advanced stages with multiple tumors spread within the peritoneal cavity. The role of Malignant Ascites (MA) is to serve as a transporter of tumor cells from the primary location to the peritoneal wall or to the surface of the peritoneal ...
Diana Luísa Almeida-Nunes, Ana Mendes-Frias, Ricardo Silvestre, Ricardo Jorge Dinis-Oliveira, Sara Ricardo   +4 more
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Extracellular vesicles in the tumor immune microenvironment

Cancer Letters, 2021
Extracellular vesicles (EVs) have gained significant attention in recent decades as major mediators of intercellular communication that are involved in various essential physiological and pathological processes. They are secreted by almost all cell types and carry bioactive materials, such as proteins, lipids and nucleic acids, that can be transmitted ...
Pei-pei Hou, Hang-zi Chen
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Molecular Immune Targeted Imaging of Tumor Microenvironment [PDF]

Nanotheranostics, 2022
Novel targeted therapies are rapidly emerging for the treatment of cancer. With the advent of new immune targeting agents, understanding the changes in the tumor microenvironment (TME) is critical. Given the complexity and several cellular mechanisms and factors that play a role in the TME, novel imaging methods to assess and evaluate the dynamic ...
Rakhshandehroo, Taha, Smith, Bryan Ronain, Glockner, Hannah J., Rashidian, Mohammad, Pandit-Taskar, Neeta   +4 more
openaire   +2 more sources