Results 31 to 40 of about 455,075 (302)
Neural regulation of cancer: from mechanobiology to inflammation. [PDF]
, 2016 Despite recent progress in cancer research, the exact nature of malignant transformation and its progression is still not fully understood. Particularly metastasis, which accounts for most cancer death, is a very complex process, and new treatment ...
Kim, Tae-Hyung +2 more
core +2 more sources
Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]
, 2019 Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence +2 more
core +2 more sources
Monitoring immune responses in the tumor microenvironment [PDF]
Current Opinion in Immunology, 2016 Immune monitoring in the tumor microenvironment allows for important insights into immune mechanisms of response and resistance to various cancer treatments; however clinical challenges exist using current strategies. Significant questions remain regarding monitoring of archival versus fresh tissue, assessment of static versus dynamic markers ...
Jennifer A, Wargo +3 more
openaire +2 more sources
Development of Immunotherapy Strategies Targeting Tumor Microenvironment Is Fiercely Ongoing
Frontiers in Immunology, 2022 Tumor immune microenvironment is a very complex system that is influenced by a wide range of factors; in this microenvironment, various immune cells, stromal cells, and cytokines can interact with tumor cells and jointly regulate this complex ecosystem ...
Rilan Bai, Jiuwei Cui
doaj +1 more source
Immune suppressive mechanisms in the tumor microenvironment [PDF]
Current Opinion in Immunology, 2016 Effective immunotherapy, whether by checkpoint blockade or adoptive cell therapy, is limited in most patients by a key barrier: the immunosuppressive tumor microenvironment. Suppression of tumor-specific T cells is orchestrated by the activity of a variety of stromal myeloid and lymphoid cells.
Munn, David H, Bronte, Vincenzo
openaire +2 more sources
Role of the tumor immune microenvironment in tumor immunotherapy (Review)
Oncology Letters, 2021 Tumor immunotherapy is considered to be a novel and promising therapy for tumors and it has recently become a hot research topic. The clinical success of tumor immunotherapy has been notable, but it has been less than totally satisfactory because tumor immunotherapy has performed poorly in numerous patients although it has shown appreciable efficacy in
Zhou, Changsheng +4 more
openaire +3 more sources
Fractionated Radiation Therapy for Large and Giant Cavernous Sinus Hemangioma: A Retrospective Study
Frontiers in Neurology, 2020 Purpose: Surgical resection has been traditionally used as a treatment for cavernous sinus hemangioma (CSH). However, this is usually difficult due to tumor vascularity and results in complications especially in large and giant CSH (volume >20 cm3 ...
Zengfeng Xin +9 more
doaj +1 more source
Evaluation of a tumor microenvironment-based prognostic score in primary operable colorectal cancer [PDF]
, 2015 Purpose: The tumor microenvironment is recognized as an important determinant of progression and outcome in colorectal cancer. The aim of the present study was to evaluate a novel tumor microenvironment–based prognostic score, based on histopathologic ...
Edwards, Joanne +6 more
core +1 more source
Journal of Experimental & Clinical Cancer Research, 2021 The efficacy of cancer immunotherapy largely depends on the tumor microenvironment, especially the tumor immune microenvironment. Emerging studies have claimed that microbes reside within tumor cells and immune cells, suggesting that these microbes can ...
Jiayao Ma +5 more
doaj +1 more source
Role of mTOR signaling in tumor microenvironment. An overview [PDF]
, 2018 The mammalian target of rapamycin (mTOR) pathway regulates major processes by integrating a variety of exogenous cues, including diverse environmental inputs in the tumor microenvironment (TME).
Bazzichetto, Chiara +8 more
core +2 more sources