Results 41 to 50 of about 463,193 (304)

The role of the tumor microbe microenvironment in the tumor immune microenvironment: bystander, activator, or inhibitor?

Journal of Experimental & Clinical Cancer Research, 2021
The efficacy of cancer immunotherapy largely depends on the tumor microenvironment, especially the tumor immune microenvironment. Emerging studies have claimed that microbes reside within tumor cells and immune cells, suggesting that these microbes can ...
Jiayao Ma, Lingjuan Huang, Die Hu, Shan Zeng, Ying Han, Hong Shen   +5 more
doaj   +1 more source

miRNAs as Influencers of Cell-Cell Communication in Tumor Microenvironment [PDF]

, 2020
microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level, inducing the degradation of the target mRNA or translational repression.
Conti, Ilaria, Laface, Ilaria, Milani, Daniela, Neri, Luca M, Rimondi, Erika, Simioni, Carolina, Varano, Gabriele   +6 more
core   +1 more source

Evaluation of a tumor microenvironment-based prognostic score in primary operable colorectal cancer [PDF]

, 2015
Purpose: The tumor microenvironment is recognized as an important determinant of progression and outcome in colorectal cancer. The aim of the present study was to evaluate a novel tumor microenvironment–based prognostic score, based on histopathologic ...
Edwards, Joanne, Horgan, Paul G., McMillan, Donald C., Park, James H., Powell, Arfon G., Richards, Colin H., Roxburgh, Campbell S.D.   +6 more
core   +1 more source

Acetylcholine From Tuft Cells: The Updated Insights Beyond Its Immune and Chemosensory Functions

Frontiers in Cell and Developmental Biology, 2020
Tuft cells, rare solitary chemosensory cells, are distributed in mucosal epithelium throughout mammalian organs. Their nomenclatures are various in different organs and may be confused with other similar cells.
Jun Pan, Jun Pan, Jun Pan, Leyi Zhang, Leyi Zhang, Leyi Zhang, Xuan Shao, Xuan Shao, Jian Huang, Jian Huang, Jian Huang   +10 more
doaj   +1 more source

Immune aspects of the breast tumor microenvironment [PDF]

Breast Cancer Management, 2013
The immune response in the tumor microenvironment is complex, consisting of cells from both the adaptive and innate immune systems. The phenotype and function of these cells are dictated by cytokines present in the microenvironment, as well as by the interactions of these cells with the tumor cells and each other.
Akhil, Chawla, Gheath, Alatrash, Yun, Wu, Elizabeth A, Mittendorf   +3 more
openaire   +2 more sources

Activated lymphocyte recruitment into the tumor microenvironment following preoperative sipuleucel-T for localized prostate cancer. [PDF]

, 2014
BackgroundSipuleucel-T is a US Food and Drug Administration-approved immunotherapy for asymptomatic or minimally symptomatic metastatic castration-resistant prostate cancer (mCRPC). Its mechanism of action is not fully understood.
Amling, Christopher L, Carroll, Peter, Chan, Stephen, Corman, John, Fong, Lawrence, Frohlich, Mark W, Lewis, Jera, Sheikh, Nadeem A, Simko, Jeffrey, Sims, Robert B, Small, Eric J, Stephenson, Robert A, Weinberg, Vivian   +12 more
core   +2 more sources

Characterizing the immune microenvironment of malignant peripheral nerve sheath tumor by PD-L1 expression and presence of CD8+ tumor infiltrating lymphocytes. [PDF]

, 2016
BackgroundMalignant peripheral nerve sheath tumor (MPNST) is an aggressive sarcoma with few treatment options. Tumor immune state has not been characterized in MPNST, and is important in determining response to immune checkpoint blockade.
Bernthal, Nicholas, Chmielowski, Bartosz, Crompton, Joseph G, Dry, Sarah, Eilber, Fritz C, Federman, Noah, Jensen, Sarah, Li, Yunfeng, Nelson, Scott, Shurell, Elizabeth, Singh, Arun S, Tumeh, Paul   +11 more
core   +2 more sources

Organoid Modeling of the Tumor Immune Microenvironment [PDF]

Cell, 2018
In vitro cancer cultures, including three-dimensional organoids, typically contain exclusively neoplastic epithelium but require artificial reconstitution to recapitulate the tumor microenvironment (TME). The co-culture of primary tumor epithelia with endogenous, syngeneic tumor-infiltrating lymphocytes (TILs) as a cohesive unit has been particularly ...
James T, Neal, Xingnan, Li, Junjie, Zhu, Valeria, Giangarra, Caitlin L, Grzeskowiak, Jihang, Ju, Iris H, Liu, Shin-Heng, Chiou, Ameen A, Salahudeen, Amber R, Smith, Brian C, Deutsch, Lillian, Liao, Allison J, Zemek, Fan, Zhao, Kasper, Karlsson, Liora M, Schultz, Thomas J, Metzner, Lincoln D, Nadauld, Yuen-Yi, Tseng, Sahar, Alkhairy, Coyin, Oh, Paula, Keskula, Daniel, Mendoza-Villanueva, Francisco M, De La Vega, Pamela L, Kunz, Joseph C, Liao, John T, Leppert, John B, Sunwoo, Chiara, Sabatti, Jesse S, Boehm, William C, Hahn, Grace X Y, Zheng, Mark M, Davis, Calvin J, Kuo   +33 more
openaire   +2 more sources

Metabolites and Immune Response in Tumor Microenvironments

Cancers, 2023
The remodeled cancer cell metabolism affects the tumor microenvironment and promotes an immunosuppressive state by changing the levels of macro- and micronutrients and by releasing hormones and cytokines that recruit immunosuppressive immune cells.
Salvatore Cortellino, Valter D. Longo
openaire   +2 more sources

Characterization of the Neuroendocrine Tumor Immune Microenvironment [PDF]

Pancreas, 2018
Objectives The immune environment and the potential for neuroendocrine tumors (NETs) to respond to immune checkpoint inhibitors remain largely unexplored. We assessed immune checkpoint marker expression, lymphocytic infiltrate, and associated mutational profiles in a cohort of small intestine and pancreatic NETs.
Annacarolina, da Silva, Michaela, Bowden, Sui, Zhang, Yohei, Masugi, Aaron R, Thorner, Zachary T, Herbert, Chensheng Willa, Zhou, Lauren, Brais, Jennifer A, Chan, F Stephen, Hodi, Scott, Rodig, Shuji, Ogino, Matthew H, Kulke   +12 more
openaire   +2 more sources