Results 41 to 50 of about 455,075 (302)

Cellular interactions in the tumor microenvironment: the role of secretome [PDF]

, 2019
Over the past years, it has become evident that cancer initiation and progression depends on several components of the tumor microenvironment, including inflammatory and immune cells, fibroblasts, endothelial cells, adipocytes, and extracellular matrix ...
Castelo-Branco, Pedro, da Cunha, Bianca Rodrigues, Domingos, Célia, Henrique, Tiago, Polachini, Giovana Mussi, Stefanini, Ana Carolina Buzzo, Tajara, Eloiza Helena   +6 more
core   +1 more source

Acetylcholine From Tuft Cells: The Updated Insights Beyond Its Immune and Chemosensory Functions

Frontiers in Cell and Developmental Biology, 2020
Tuft cells, rare solitary chemosensory cells, are distributed in mucosal epithelium throughout mammalian organs. Their nomenclatures are various in different organs and may be confused with other similar cells.
Jun Pan, Jun Pan, Jun Pan, Leyi Zhang, Leyi Zhang, Leyi Zhang, Xuan Shao, Xuan Shao, Jian Huang, Jian Huang, Jian Huang   +10 more
doaj   +1 more source

Drosophila as a model system to study nonautonomous mechanisms affecting tumour growth and cell death [PDF]

, 2018
The study of cancer has represented a central focus in medical research for over a century. The great complexity and constant evolution of the pathology require the use of multiple research model systems and interdisciplinary approaches.
Cordero, Julia B., Hodgson, Joseph A., Parvy, Jean-Philippe   +2 more
core   +7 more sources

Exploiting the neoantigen landscape for immunotherapy of pancreatic ductal adenocarcinoma [PDF]

, 2016
Immunotherapy approaches for pancreatic ductal adenocarcinoma (PDAC) have met with limited success. It has been postulated that a low mutation load may lead to a paucity of T cells within the tumor microenvironment (TME).
Alvarez, Hector A., Bailey, Peter, Biankin, Andrew V., Chang, David K., Chattopadhyay, Chandrani, Ekmekcioglu, Suhendan, Forget, Marie-Andrée, Grimm, Elizabeth A., Haymaker, Cara, Hwu, Patrick, Kim, Sun-Hee, Maitra, Anirban, Roszik, Jason, San Lucas, Francis A.   +13 more
core   +1 more source

Immune aspects of the breast tumor microenvironment [PDF]

Breast Cancer Management, 2013
The immune response in the tumor microenvironment is complex, consisting of cells from both the adaptive and innate immune systems. The phenotype and function of these cells are dictated by cytokines present in the microenvironment, as well as by the interactions of these cells with the tumor cells and each other.
Akhil, Chawla, Gheath, Alatrash, Yun, Wu, Elizabeth A, Mittendorf   +3 more
openaire   +2 more sources

Characterizing the immune microenvironment of malignant peripheral nerve sheath tumor by PD-L1 expression and presence of CD8+ tumor infiltrating lymphocytes. [PDF]

, 2016
BackgroundMalignant peripheral nerve sheath tumor (MPNST) is an aggressive sarcoma with few treatment options. Tumor immune state has not been characterized in MPNST, and is important in determining response to immune checkpoint blockade.
Bernthal, Nicholas, Chmielowski, Bartosz, Crompton, Joseph G, Dry, Sarah, Eilber, Fritz C, Federman, Noah, Jensen, Sarah, Li, Yunfeng, Nelson, Scott, Shurell, Elizabeth, Singh, Arun S, Tumeh, Paul   +11 more
core   +2 more sources

Organoid Modeling of the Tumor Immune Microenvironment [PDF]

Cell, 2018
In vitro cancer cultures, including three-dimensional organoids, typically contain exclusively neoplastic epithelium but require artificial reconstitution to recapitulate the tumor microenvironment (TME). The co-culture of primary tumor epithelia with endogenous, syngeneic tumor-infiltrating lymphocytes (TILs) as a cohesive unit has been particularly ...
James T, Neal, Xingnan, Li, Junjie, Zhu, Valeria, Giangarra, Caitlin L, Grzeskowiak, Jihang, Ju, Iris H, Liu, Shin-Heng, Chiou, Ameen A, Salahudeen, Amber R, Smith, Brian C, Deutsch, Lillian, Liao, Allison J, Zemek, Fan, Zhao, Kasper, Karlsson, Liora M, Schultz, Thomas J, Metzner, Lincoln D, Nadauld, Yuen-Yi, Tseng, Sahar, Alkhairy, Coyin, Oh, Paula, Keskula, Daniel, Mendoza-Villanueva, Francisco M, De La Vega, Pamela L, Kunz, Joseph C, Liao, John T, Leppert, John B, Sunwoo, Chiara, Sabatti, Jesse S, Boehm, William C, Hahn, Grace X Y, Zheng, Mark M, Davis, Calvin J, Kuo   +33 more
openaire   +2 more sources

Metabolites and Immune Response in Tumor Microenvironments

Cancers, 2023
The remodeled cancer cell metabolism affects the tumor microenvironment and promotes an immunosuppressive state by changing the levels of macro- and micronutrients and by releasing hormones and cytokines that recruit immunosuppressive immune cells.
Salvatore Cortellino, Valter D. Longo
openaire   +2 more sources

Immunometabolism in the tumor microenvironment and its related research progress

Frontiers in Oncology, 2022
The tumor immune microenvironment has been a research hot spot in recent years. The cytokines and metabolites in the microenvironment can promote the occurrence and development of tumor in various ways and help tumor cells get rid of the surveillance of ...
Ziheng Zhang, Yajun Hu, Yuefeng Chen, Zhuoneng Chen, Yexin Zhu, Mingmin Chen, Jichu Xia, Yixuan Sun, Wenfang Xu   +8 more
doaj   +1 more source

Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity. [PDF]

, 2018
Here we introduce Protein-indexed Assay of Transposase Accessible Chromatin with sequencing (Pi-ATAC) that combines single-cell chromatin and proteomic profiling. In conjunction with DNA transposition, the levels of multiple cell surface or intracellular
Chang, Howard Y, Chen, Xingqi, Choudhry, Hani, Giaccia, Amato J, Greenleaf, William J, LaGory, Edward L, Litzenburger, Ulrike M, Schep, Alicia N, Wei, Yuning   +8 more
core   +2 more sources