Results 1 to 10 of about 147,089 (90)

Rotavirus NSP1 Inhibits Type I and Type III Interferon Induction [PDF]

Viruses, 2021
Type I interferons (IFNs) are produced by most cells in response to virus infection and stimulate a program of anti-viral gene expression in neighboring cells to suppress virus replication. Type III IFNs have similar properties, however their effects are
Gennaro Iaconis, Ben Jackson, Kay Childs, Mark Boyce, Stephen Goodbourn, Neil Blake, Miren Iturriza-Gomara, Julian Seago   +7 more
doaj   +2 more sources

Pseudorabies virus-induced expression and antiviral activity of type I or type III interferon depend on the type of infected epithelial cell [PDF]

Frontiers in Immunology, 2022
Type I and III Interferons (IFNs) are the initial antiviral cytokines produced in response to virus infection. These IFNs in turn bind to their respective receptors, trigger JAK-STAT signaling and induce the expression of IFN-stimulated genes (ISGs) to ...
Yue Yin, Jinglin Ma, Cliff Van Waesberghe, Bert Devriendt, Herman W. Favoreel   +4 more
doaj   +2 more sources

Type III interferon exerts thymic stromal lymphopoietin in mediating adaptive antiviral immune response [PDF]

Frontiers in Immunology, 2023
Previously, it was believed that type III interferon (IFN-III) has functions similar to those of type I interferon (IFN-I). However, recently, emerging findings have increasingly indicated the non-redundant role of IFN-III in innate antiviral immune ...
Luhong Cao, Weiwei Qian, Wanlin Li, Zhiyue Ma, Shenglong Xie   +4 more
doaj   +2 more sources

Context‐specific anti‐inflammatory roles of type III interferon signaling in the lung in nonviral injuries [PDF]

Physiological Reports
Type III interferons (λ1, λ2, and λ3) are potent antiviral cytokines in the lung. However, their roles in nonviral lung injuries are less well understood. This study investigates the activation of type III interferon signaling in three distinct models of
Jingjing Feng, Jooyoung Kim, Victoria D. Wang, De Chang, Hongbo Liu, William G. Bain, Keven M. Robinson, Zhijun Jie, Sergei V. Kotenko, Charles S. Dela Cruz, Lokesh Sharma   +10 more
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Type III interferon drives pathogenicity to Staphylococcus aureus via the airway epithelium [PDF]

mBio
Type III interferon signaling contributes to the pathogenesis of the important human pathogen Staphylococcus aureus in the airway. Little is known of the cellular factors important in this response.
Silvia Pires, Katherine Kaiser, Dane Parker   +2 more
doaj   +2 more sources

Favorable Genotypes of Type III Interferon Confer Risk of Dyslipidemia in the Population With Obesity [PDF]

Frontiers in Endocrinology, 2022
BackgroundStudies have indicated that the chronic state of inflammation caused by obesity leads to dyslipidemia. However, how the polymorphisms involved in these inflammatory pathways affect the lipid metabolism in people with obesity is poorly ...
Tiantian Xu, Tiantian Xu, Tiantian Xu, Tiantian Xu, Bo Peng, Mengmeng Liu, Mengmeng Liu, Mengmeng Liu, Qingjing Liu, Qingjing Liu, Qingjing Liu, Junya Yang, Minli Qu, Minli Qu, Minli Qu, Na Liu, Na Liu, Na Liu, Lizhen Lin, Lizhen Lin, Lizhen Lin, Jing Wu, Jing Wu, Jing Wu, Jing Wu   +24 more
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Differential type I and type III interferon expression profiles in rheumatoid and juvenile idiopathic arthritis [PDF]

Frontiers in Medicine
BackgroundThe role of type I and type III interferons (IFNs) in rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA) is still poorly understood.
Anikó E. Malik, Anikó E. Malik, Drew Slauenwhite, Drew Slauenwhite, Sarah M. McAlpine, Sarah M. McAlpine, John G. Hanly, John G. Hanly, Jean S. Marshall, Beáta Dérfalvi, Beáta Dérfalvi, Thomas B. Issekutz, Thomas B. Issekutz   +12 more
doaj   +2 more sources

Inhibition of Type III Interferon Expression in Intestinal Epithelial Cells—A Strategy Used by Coxsackie B Virus to Evade the Host’s Innate Immune Response at the Primary Site of Infection? [PDF]

Microorganisms, 2021
Increasing evidence highlights the importance of the antiviral activities of the type III interferons (IFNλs; IL-28A, IL-28B, IL29, and IFNλ4) in the intestine.
Virginia M. Stone, Emma E. Ringqvist, Pär G. Larsson, Erna Domsgen, Ulrika Holmlund, Eva Sverremark-Ekström, Malin Flodström-Tullberg   +6 more
doaj   +2 more sources

Editorial: Type I and Type III Interferon Immune Responses in Asthma [PDF]

Frontiers in Immunology, 2022
Susetta Finotto, Tuomas Jartti, Tuomas Jartti, Tuomas Jartti, Sebastian L. Johnston   +4 more
doaj   +2 more sources

The Coronavirus PEDV Evades Type III Interferon Response Through the miR-30c-5p/SOCS1 Axis [PDF]

Frontiers in Microbiology, 2020
Porcine epidemic diarrhea virus (PEDV) is an economically important pathogen that has evolved several mechanisms to evade type I IFN responses. Type III interferon (IFN-λ), an innate cytokine that primarily targets the mucosal epithelia, is critical in ...
Changlin Wang, Lingling Shan, Shuxin Qu, Mei Xue, Keliang Wang, Fang Fu, Lu Wang, Ziqi Wang, Li Feng, Wanhai Xu, Pinghuang Liu   +10 more
doaj   +2 more sources