Type I and type III interferon in opposition? [PDF]
Nat Rev Immunol, 2020 Park MD.
europepmc +6 more sources
Photochemotherapy Induces Interferon Type III Expression via STING Pathway [PDF]
Cells, 2020 DNA-damaging cancer therapies induce interferon expression and stimulate the immune system, promoting therapy responses. The immune-activating STING (Stimulator of Interferon Genes) pathway is induced when DNA or double-stranded RNA (dsRNA) is detected ...
Edyta Biskup +6 more
doaj +5 more sources
Diverse intracellular pathogens activate type III interferon expression from peroxisomes [PDF]
Nature Immunology, 2014 Type I interferon responses are considered the primary means by which viral infections are controlled in mammals. Despite this view, several pathogens activate antiviral responses in the absence of type I interferons. The mechanisms controlling type I interferon-independent responses are undefined.
Odendall, Charlotte +9 more
openaire +6 more sources
Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance. [PDF]
PLoS Pathogens, 2018 It is currently believed that type I and III interferons (IFNs) have redundant functions. However, the preferential distribution of type III IFN receptor on epithelial cells suggests functional differences at epithelial surfaces.
Kalliopi Pervolaraki +10 more
doaj +4 more sources
The bacterial pathogen Listeria monocytogenes and the interferon family: type I, type II and type III interferons [PDF]
Frontiers in Cellular and Infection Microbiology, 2014 Interferons (IFNs) are secreted proteins of the cytokine family that regulate innate and adaptive immune responses to infection. Although the importance of IFNs in the antiviral response has long been appreciated, their role in bacterial infections is ...
Olivier eDussurget +2 more
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Antiviral Type I and Type III Interferon Responses in the Central Nervous System [PDF]
Viruses, 2013 The central nervous system (CNS) harbors highly differentiated cells, such as neurons that are essential to coordinate the functions of complex organisms. This organ is partly protected by the blood-brain barrier (BBB) from toxic substances and pathogens
Thomas Michiels +4 more
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Herpesviruses and the Type III Interferon System. [PDF]
Virol Sin, 2021 Type III interferons (IFNs) represent the most recently discovered group of IFNs. Together with type I IFNs (e.g. IFN-α/β), type III IFNs (IFN-λ) are produced as part of the innate immune response to virus infection, and elicit an anti-viral state by inducing expression of interferon stimulated genes (ISGs).
Yin Y, Favoreel HW.
europepmc +4 more sources
Type III Interferons: Emerging Roles in Autoimmunity [PDF]
Frontiers in Immunology, 2021 Type III interferons (IFNs) or the lambda IFNs (IFNLs or IFN-λs) are antimicrobial cytokines that play key roles in immune host defense at endothelial and epithelial barriers. IFNLs signal via their heterodimeric receptor, comprised of two subunits, IFNLR1 and interleukin (IL)10Rβ, which defines the cellular specificity of the responses to the ...
Sindhu Manivasagam +5 more
openaire +4 more sources
Congenital Zika Syndrome Is Associated With Interferon Alfa Receptor 1
Frontiers in Immunology, 2021 Host factors that influence Congenital Zika Syndrome (CZS) outcome remain elusive. Interferons have been reported as the main antiviral factor in Zika and other flavivirus infections.
Tamiris Azamor +21 more
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Sarbecovirus ORF6 proteins hamper induction of interferon signaling
Cell Reports, 2021 Summary: The presence of an ORF6 gene distinguishes sarbecoviruses such as severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 from other betacoronaviruses.
Izumi Kimura +6 more
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