Results 21 to 30 of about 147,258 (248)
Insights Into Type I and III Interferons in Asthma and Exacerbations
Frontiers in Immunology, 2020 Asthma is a highly prevalent, chronic respiratory disease that impacts millions of people worldwide and causes thousands of deaths every year.
Helen E. Rich +4 more
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Regulation of apoptosis by type III interferons [PDF]
Cell Proliferation, 2008 Abstract. Objective: Two types of interferons (IFNs), type I (IFN‐α/β) and type III (IFN‐λs), utilize distinct receptor complexes to induce similar signalling and biological activities, including recently demonstrated for IFN‐λs antitumour activity. However, ability of type III IFNs to regulate cell population growth remains largely uncharacterized ...
W, Li +4 more
openaire +2 more sources
Importance of Type I and III Interferons at Respiratory and Intestinal Barrier Surfaces
Frontiers in Immunology, 2020 Interferons (IFNs) constitute the first line of defense against microbial infections particularly against viruses. They provide antiviral properties to cells by inducing the expression of hundreds of genes known as interferon-stimulated genes (ISGs). The
Megan L. Stanifer +4 more
doaj +1 more source
Differential Regulation of Type I and Type III Interferon Signaling. [PDF]
Int J Mol Sci, 2019 Interferons (IFNs) are very powerful cytokines, which play a key role in combatting pathogen infections by controlling inflammation and immune response by directly inducing anti-pathogen molecular countermeasures. There are three classes of IFNs: type I, type II and type III.
Stanifer ML, Pervolaraki K, Boulant S.
europepmc +4 more sources
Type III Interferons in Hepatitis C Virus Infection [PDF]
Frontiers in Immunology, 2016 The interferon (IFN)-λ family of type III cytokines includes the closely related interleukin (IL)-28A (IFN-λ2), IL-28B (IFN-λ3), and IL-29 (IFN-λ1). They signal through the Janus kinases (JAK)-signal transducers and activators of transcription pathway and promote an antiviral state by the induction of expression of several interferon-stimulated genes ...
Boisvert, Maude, Shoukry, Naglaa H.
openaire +2 more sources
Antiviral Functions of Type I and Type III Interferons in the Olfactory Epithelium
Biomolecules, 2023 The olfactory neuroepithelium (OE) is one of the few neuronal tissues where environmental pathogens can gain direct access. Despite this vulnerable arrangement, little is known about the protective mechanisms in the OE to prevent viral infection and its ...
Ahmad Zedan +6 more
doaj +1 more source
The Role of Structure in the Biology of Interferon Signaling
Frontiers in Immunology, 2020 Interferons (IFNs) are a family of cytokines with the unique ability to induce cell intrinsic programs that enhance resistance to viral infection. Induction of an antiviral state at the cell, tissue, organ, and organismal level is performed by three ...
Mark R. Walter
doaj +1 more source
Microbial pathogenesis and type III interferons
Cytokine & Growth Factor Reviews, 2016 The innate immune system possesses a multitude of pathways to sense and respond to microbial pathogens. One such family are the interferons (IFNs), a family of cytokines that are involved in several cellular functions. Type I IFNs are appreciated to be important in several viral and bacterial diseases, while the recently identified type III IFNs (IFNL1,
Cohen, Taylor S., Parker, Dane
openaire +2 more sources
Human interferon-λ3 is a potent member of the type III interferon family [PDF]
Genes & Immunity, 2008 Type III interferon (IFN) or IFN-lambda is a recently discovered family of IFNs that signal through the same downstream transcription factors as type I IFN but use a separate receptor complex composed of the IL-10R2 and the unique IFN-lambdaR1 receptor chains.
Dellgren, C +4 more
openaire +3 more sources
Viruses, 2022 Paramyxoviridae is a viral family within the order of Mononegavirales; they are negative single-strand RNA viruses that can cause significant diseases in both humans and animals.
Giuseppe Pisanelli +3 more
doaj +1 more source