Results 31 to 40 of about 147,258 (248)
Shared and Distinct Functions of Type I and Type III Interferons [PDF]
Immunity, 2019 Type I interferons (IFNs) (IFN-α, IFN-β) and type III IFNs (IFN-λ) share many properties, including induction by viral infection, activation of shared signaling pathways, and transcriptional programs. However, recent discoveries have revealed context-specific functional differences.
Helen M, Lazear +2 more
openaire +2 more sources
The Capsule of Acinetobacter baumannii Protects against the Innate Immune Response
Journal of Innate Immunity, 2022 Acinetobacter baumannii is an opportunistic pathogen that has recently emerged as a global threat associated with high morbidity, mortality, and antibiotic resistance. We determined the role of type I interferon (IFN) signaling in A. baumannii infection.
Lavoisier Akoolo +3 more
doaj +1 more source
Novel Nonviral Bioassays for Mouse Type I and Type III Interferon [PDF]
Journal of Interferon & Cytokine Research, 2011 We used embryo fibroblasts from Mx2-Luc transgenic mice that express Firefly luciferase under control of the interferon (IFN)-regulated mouse Mx2 promoter to develop simple nonviral bioassays for type I and type III IFN. Since type III IFN is acid-labile, Mx2-Luc fibroblasts detected the presence of type I IFN in acid-treated biological samples with ...
Kugel, Daniela +4 more
openaire +4 more sources
Inhibition of SARS–CoV-2 by type I and type III interferons [PDF]
Journal of Biological Chemistry, 2020 The recently emerged severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of the devastating COVID-19 lung disease pandemic. Here, we tested the inhibitory activities of the antiviral interferons of type I (IFN-α) and type III (IFN-λ) against SARS-CoV-2 and compared them with those against SARS-CoV-1, which emerged in ...
Felgenhauer, Ulrike +7 more
openaire +2 more sources
Virulence, 2020 Antibodies play a critical protective role in the host response to blood-stage malaria infection. The role of cytokines in shaping the antibody response to blood-stage malaria is unclear.
William O. Hahn +2 more
doaj +1 more source
The Role of Type III Interferons in Human Disease
Clinical and Investigative Medicine, 2021 Purpose This literature review summarizes the main immunological characteristics of type III interferons (IFN) and highlights the clinically relevant aspects and future therapeutic perspectives for these inflammatory molecules. Source Relevant articles in PubMed MEDLINE from the first publication (2003) until 2020.
Malik, Anikó Éva +2 more
openaire +4 more sources
Viral Immunology, 2021 While an appropriately regulated production of interferons (IFNs) performs a fundamental role in the defense against coronaviruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), dysregulated overproduction of inflammatory mediators can play an important role in the development of SARS-CoV-2 infection-related complications, such ...
Jafarzadeh, Abdollah +4 more
openaire +2 more sources
Frontiers in Immunology, 2021 STAT2 is a transcription factor that plays an essential role in antiviral immunity by mediating the activity of type I and III interferons (IFN-I and IFN-III).
Bishara J. Freij +7 more
doaj +1 more source
Type III Interferons in Antiviral Defenses at Barrier Surfaces [PDF]
Trends in Immunology, 2018 Barrier surfaces such as the epithelium lining the respiratory and gastrointestinal (GI) tracts, the endothelium comprising the blood-brain barrier (BBB), and placental trophoblasts provide key physical and immunological protection against viruses. These barriers utilize nonredundant mechanisms to suppress viral infections including the production of ...
Wells, Alexandra I, Coyne, Carolyn B
openaire +2 more sources
PLoS ONE, 2013 Defective Rhinovirus induced interferon-β and interferon-λ production has been reported in bronchial epithelial cells from asthmatics but the mechanisms of defective interferon induction in asthma are unknown.
Annemarie Sykes +8 more
doaj +1 more source