Results 111 to 120 of about 706,934 (223)

Synthesis, biological evaluation, molecular docking, MD simulation and DFT analysis of new 3-hydroxypyridine-4-one derivatives as anti-tyrosinase and antioxidant agents

Heliyon
In the present study, ten new substituted 3-hydroxypyridine-4-one derivatives were synthesized in a four-step method, and their chemical structures were confirmed using various spectroscopic techniques.
Sara Sadeghian, Fateme Zare, Mehdi Khoshneviszadeh, Arian Fathi Hafshejani, Farhang Salahshour, Ahmadreza Khodabakhshloo, Lotfollah Saghaie, Ghazal Goshtasbi, Zahra Sarikhani, Alireza Poustforoosh, Razieh Sabet, Hossein Sadeghpour   +11 more
doaj   +1 more source

Beyond monofunctionality: structural perspectives on phenol oxidase side activity in a catalase

Acta Crystallographica Section D, Volume 82, Issue 11, Page 1224-1239, November 2026.
Structural and biochemical characterization of the extracellular fungal catalase ClCPO uncovers an unexpected phenol oxidase promiscuity. Crystal structures, substrate docking and electron‐transfer pathway analysis identify ligand‐binding regions and support a working mechanistic model for catalase‐associated phenol oxidase activity.Catalases are ...
Christina Ferousi, Christos Kosinas, Odyssefs Ioannis Pantelakis, Efstratios Nikolaivits, Evangelos Topakas, Maria Dimarogona   +5 more
wiley   +1 more source

Hop Tannins as Multifunctional Tyrosinase Inhibitor: Structure Characterization, Inhibition Activity, and Mechanism. [PDF]

Antioxidants (Basel), 2022
Liu J, Chen Y, Zhang X, Zheng J, Hu W, Teng B.   +5 more
europepmc   +1 more source

The Cutaneous Melatoninergic System: Endogenous Biology and Potential for Therapeutic Targeting

Experimental Dermatology, Volume 35, Issue 11, November 2026.
ABSTRACT Melatonin is best known as a pineal hormone that regulates circadian rhythms, but the skin also possesses an intrinsic melatoninergic system capable of local synthesis, metabolism and signalling. This system encompasses classical melatonin receptors, biologically active metabolites, non‐classical signalling pathways and receptor‐independent ...
Ju Hee Han, Hei Sung Kim
wiley   +1 more source

Kojic acid-derived tyrosinase inhibitors: synthesis and bioactivity

Pharmaceutical and Biomedical Research, 2015
Tyrosinase is a key enzyme for melanin biosynthesis, catalyzing the oxidation of L-tyrosine to L-dopaquinone. The tyrosinase inhibition is an effective approach to control hyperpigmentation in human skin and enzymatic browning in fruits and vegetables ...
Seyedeh Mahdieh Hashemi, Saeed Emami
doaj  

HuR Confers Resistance of Hepatocellular Carcinoma to Lenvatinib by Inhibiting Ferroptosis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 21, November 2026.
ABSTRACT This study aim to explore whether human antigen R (HuR) inhibits ferroptosis confers resistance to lenvatinib in hepatocellular carcinoma (HCC). Bioinformatics analysis and immunofluorescence detection of 30 HCC tissue samples were used to verify the clinical correlation between HuR and glutathione peroxidase 4 (GPX4), establish a lenvatinib ...
Siren Feng, Fang Wang, Huayi Wu, Xinran Lin, Xue Qi, Kun Liu, Qiushi Yin, Bo Lin, Mengsen Li, Mingyue Zhu   +9 more
wiley   +1 more source

From Fish Scale Gelatin to Tyrosinase Inhibitor: A Novel Peptides Screening Approach Application. [PDF]

Front Nutr, 2022
Hu ZZ, Sha XM, Zhang L, Zha MJ, Tu ZC.
europepmc   +1 more source

Females Display Greater Disease Severity in a Mouse Model of Vitiligo

Pigment Cell &Melanoma Research, Volume 39, Issue 6, November 2026.
We compared depigmentation in vitiligo‐prone, h3TA2 mice among males and females, and explored the effects of treatment with HSP70iQ435A plasmid DNA, delivered by biolistic administration. Mice shown from each cohort exemplify increased depigmentation among female mice and the treatment benefit of HSP70iQ435A. ABSTRACT Vitiligo is an autoimmune disease
Kaitlyn G. O'Donnell, Zhussipbek Mukhatayev, Hanin Abuzer, Rohan S. Shivde, Sriram Saravanan Shanmugavelandy, Octavio K. Bartos, Ellis Kang, Emilia R. Dellacecca, Dinesh Jaishankar, Surya Pandey, Hee Kap Kang, Ziyou Ren, I. Caroline Le Poole   +12 more
wiley   +1 more source

Synthesis and biological assessment of novel 4H-chromene-3-carbonitrile derivatives as tyrosinase inhibitors

BMC Chemistry
Excessive activity of the tyrosinase enzyme during melanogenesis results in hyperpigmentation in the skin. To address this issue, there is a need to develop effective tyrosinase inhibitors as a treatment for hyperpigmentation.
Mohammad Azimi, Zahra Najafi, Asrin Bahmani, Gholamabbas Chehardoli, Aida Iraji   +4 more
doaj   +1 more source

Design and synthesis of novel dihydropyridine- and benzylideneimine-based tyrosinase inhibitors

Frontiers in Pharmacology
Tyrosinase (TYR) inhibitors are very significant as they inhibit enzyme tyrosinase activity, and its inhibition is vital for skin care, anticancer medication, and antibrowning of fruits and vegetables.
Ifraz Ahmad, Warda Parveen, Shah Noor, Zahoor Udin, Amjad Ali, Ijaz Ali, Riaz Ullah, Hamid Ali   +7 more
doaj   +1 more source