Controlled rotation mechanism of DNA strand exchange by the Hin serine recombinase. [PDF]
, 2016 DNA strand exchange by serine recombinases has been proposed to occur by a large-scale rotation of halves of the recombinase tetramer. Here we provide the first direct physical evidence for the subunit rotation mechanism for the Hin serine invertase ...
Johnson, Reid C +4 more
core +1 more source
The integrase family of tyrosine recombinases: evolution of a conserved active site domain [PDF]
Nucleic Acids Research, 1997 The integrases are a diverse family of tyrosine recombinases which rearrange DNA duplexes by means of conservative site-specific recombination reactions. Members of this family, of which the well-studied lambda Int protein is the prototype, were previously found to share four strongly conserved residues, including an active site tyrosine directly ...
D, Esposito, J J, Scocca
openaire +2 more sources
Initial characterization of the Pf-Int recombinase from the malaria parasite Plasmodium falciparum.
PLoS ONE, 2012 BackgroundGenetic variation is an essential means of evolution and adaptation in many organisms in response to environmental change. Certain DNA alterations can be carried out by site-specific recombinases (SSRs) that fall into two families: the serine ...
Mehdi Ghorbal +9 more
doaj +1 more source
The complete plastid genomes of the two 'dinotoms' Durinskia baltica and Kryptoperidinium foliaceum. [PDF]
PLoS ONE, 2010 In one small group of dinoflagellates, photosynthesis is carried out by a tertiary endosymbiont derived from a diatom, giving rise to a complex cell that we collectively refer to as a 'dinotom'.
Behzad Imanian +2 more
doaj +1 more source
A Topological Characterization Of Knots and Links Arising From Site-Specific Recombination [PDF]
, 1998 We develop a topological model of knots and links arising from a single (or multiple processive) round(s) of recombination starting with an unknot, unlink, or (2,m)-torus knot or link substrate.
Jones, JB +3 more
core +2 more sources
The Evolution of Tyrosine-Recombinase Elements in Nematoda
PLoS ONE, 2014 18 ...
Szitenberg, Amir +3 more
openaire +6 more sources
Self‐control in DNA site‐specific recombination mediated by the tyrosine recombinase TnpI [PDF]
Molecular Microbiology, 2006 SummaryTn4430is a distinctive transposon of the Tn3family that encodes a tyrosine recombinase (TnpI) to resolve replicative transposition intermediates. The internal resolution site of Tn4430(IRS, 116 bp) contains two inverted repeats (IR1 and IR2) at the crossover core site, and two additional TnpI binding motifs (DR1 and DR2) adjacent to the core ...
Virginie, Vanhooff +5 more
openaire +5 more sources
Flipping chromosomes in deep-sea archaea. [PDF]
PLoS Genetics, 2017 One of the major mechanisms driving the evolution of all organisms is genomic rearrangement. In hyperthermophilic Archaea of the order Thermococcales, large chromosomal inversions occur so frequently that even closely related genomes are difficult to ...
Matteo Cossu +7 more
doaj +1 more source
PLoS ONE, 2022 The exchange of antimicrobial resistance (AMR) genes between aquaculture and terrestrial microbial populations has emerged as a serious public health concern. However, the nature of the mobile genetic elements in marine bacteria is poorly documented.
Lisa Nonaka +2 more
doaj +1 more source
Controlling tetramer formation, subunit rotation and DNA ligation during Hin-catalyzed DNA inversion. [PDF]
, 2015 Two critical steps controlling serine recombinase activity are the remodeling of dimers into the chemically active synaptic tetramer and the regulation of subunit rotation during DNA exchange.
Chang, Yong, Johnson, Reid C
core +3 more sources