Results 51 to 60 of about 4,897 (216)

Sequence analysis allows functional annotation of tyrosine recombinases in prokaryotic genomes [PDF]

, 2019
ABSTRACTBackgroundTyrosine recombinases perform site-specific genetic recombination in bacteria and archaea. They safeguard genome integrity by resolving chromosome multimers, as well as mobilize transposons, phages and integrons, driving dissemination of genetic traits and antibiotic resistance.
Smyshlyaev, Georgy, Barabas, Orsolya, Bateman, Alex   +2 more
openaire   +1 more source

Single-Molecule Tethered Particle Motion: Stepwise Analyses of Site-Specific DNA Recombination

Micromachines, 2018
Tethered particle motion/microscopy (TPM) is a biophysical tool used to analyze changes in the effective length of a polymer, tethered at one end, under changing conditions.
Hsiu-Fang Fan, Chien-Hui Ma, Makkuni Jayaram   +2 more
doaj   +1 more source

Strategies to Achieve Conditional Gene Mutation in Mice [PDF]

, 2018
The laboratory mouse is an ideal model organism for studying disease because it is physiologically similar to human and also because its genome is readily manipulated.
Gierut, J. J., Haigis, K. M., Jacks, Tyler E.   +2 more
core   +1 more source

Tight regulation of the intS gene of the KplE1 prophage: a new paradigm for integrase gene regulation. [PDF]

PLoS Genetics, 2010
Temperate phages have the ability to maintain their genome in their host, a process called lysogeny. For most, passive replication of the phage genome relies on integration into the host's chromosome and becoming a prophage.
Gaël Panis, Yohann Duverger, Elise Courvoisier-Dezord, Stéphanie Champ, Emmanuel Talla, Mireille Ansaldi   +5 more
doaj   +1 more source

Dynamic state of plasmid genomic architectures resulting from XerC/D-mediated site-specific recombination in Acinetobacter baumannii Rep_3 superfamily resistance plasmids carrying blaOXA-58- and TnaphA6-resistance modules

Frontiers in Microbiology, 2023
The acquisition of blaOXA genes encoding different carbapenem-hydrolyzing class-D β-lactamases (CHDL) represents a main determinant of carbapenem resistance in the nosocomial pathogen Acinetobacter baumannii.
Lucía Giacone, M. Marcela Cameranesi, Rocío I. Sanchez, Adriana S. Limansky, Jorgelina Morán-Barrio, Alejandro M. Viale   +5 more
doaj   +1 more source

Characterization of Knots and Links Arising From Site-specific Recombination on Twist Knots

, 2011
We develop a model characterizing all possible knots and links arising from recombination starting with a twist knot substrate, extending previous work of Buck and Flapan. We show that all knot or link products fall into three well-understood families of
Buck D, Burde G, Conway J H, Cox M M, Cozzarelli N R, Craig N, Cromwell P, Darcy I K Ishihara K Medikonduri R Shimokawa K, Dorothy Buck, Karin Valencia, Kawauchi A, Maxwell A, Rolfsen D, Shimokawa K Ishihara K Vazquez M, Valencia K Buck D, Wang James C, Zechiedrich L E   +16 more
core   +1 more source

ALOG domains: provenance of plant homeotic and developmental regulators from the DNA-binding domain of a novel class of DIRS1-type retroposons

Biology Direct, 2012
Members of the Arabidopsis LSH1 and Oryza G1 (ALOG) family of proteins have been shown to function as key developmental regulators in land plants. However, their precise mode of action remains unclear.
Iyer Lakshminarayan M, Aravind L
doaj   +1 more source

Mobile Element Integration Reveals a Chromosome Dimer Resolution System in Legionellales

mBio, 2022
In bacteria, the mechanisms used to repair DNA lesions during genome replication include homologous recombination between sister chromosomes. This can lead to the formation of chromosome dimers if an odd number of crossover events occurs. The dimers must
Beth Nicholson, Shayna R. Deecker, Alexander W. Ensminger   +2 more
doaj   +1 more source

Predicting Knot or Catenane Type of Site-Specific Recombination Products

, 2007
Site-specific recombination on supercoiled circular DNA yields a variety of knotted or catenated products. We develop a model of this process, and give extensive experimental evidence that the assumptions of our model are reasonable. We then characterize
Buck, Dorothy, Flapan, Erica
core   +1 more source

Draft Genome Sequence of Mycobacterium heckeshornense Strain RLE. [PDF]

, 2015
We report here the draft genome sequence of Mycobacterium heckeshornense strain RLE isolated from a sputum sample from a patient with shortness of breath.
Chiu, Charles Y, Cunningham, Gail, Greninger, Alexander L, Miller, Steve   +3 more
core   +1 more source