Results 21 to 30 of about 13,810 (181)

Role of Coenzyme Q₁₀ in Health and Disease: An Update on the Last 10 Years (2010–2020)

Antioxidants, 2021
The present review focuses on preclinical and clinical studies conducted in the last decade that contribute to increasing knowledge on Coenzyme Q10’s role in health and disease.
Ilenia Cirilli, Elisabetta Damiani, Phiwayinkosi Vusi Dludla, Iain Hargreaves, Fabio Marcheggiani, Lauren Elizabeth Millichap, Patrick Orlando, Sonia Silvestri, Luca Tiano   +8 more
doaj   +1 more source

Ubiquinol decreases monocytic expression and DNA methylation of the pro-inflammatory chemokine ligand 2 gene in humans

BMC Research Notes, 2012
Background Coenzyme Q10 is an essential cofactor in the respiratory chain and serves in its reduced form, ubiquinol, as a potent antioxidant. Studies in vitro and in vivo provide evidence that ubiquinol reduces inflammatory processes via gene expression.
Fischer Alexandra, Onur Simone, Schmelzer Constance, Döring Frank   +3 more
doaj   +1 more source

Effect of Ubiquinol Therapy on Sperm Parameters and Serum Testosterone Levels in Oligoasthenozoospermic Infertile Men [PDF]

Journal of Clinical and Diagnostic Research, 2015
Introduction: The male sperm counts decline due to environmental factors, such as pesticides, heavy metals and exogenous estrogens causing negative impact on spermatogenesis.
Amar Singh Thakur, Gian Paolo Littarru, Iwao Funahashi, Umeshwar Singh Painkara, Narendra Shriram Dange, Prabha Chauhan   +5 more
doaj   +1 more source

Ubiquinol Supplementation Improves Gender-Dependent Cerebral Vasoreactivity and Ameliorates Chronic Inflammation and Endothelial Dysfunction in Patients with Mild Cognitive Impairment

Antioxidants, 2021
Ubiquinol can protect endothelial cells from multiple mechanisms that cause endothelial damage and vascular dysfunction, thus contributing to dementia. A total of 69 participants diagnosed with mild cognitive impairment (MCI) received either 200 mg/day ...
Sonia García-Carpintero, Javier Domínguez-Bértalo, Cristina Pedrero-Prieto, Javier Frontiñán-Rubio, Mariano Amo-Salas, Mario Durán-Prado, Eloy García-Pérez, Julia Vaamonde, Francisco J. Alcain   +8 more
doaj   +1 more source

Mitochondrial ubiquinol oxidation is necessary for tumour growth [PDF]

Nature, 2020
The mitochondrial electron transport chain (ETC) is necessary for tumour growth1-6 and its inhibition has demonstrated anti-tumour efficacy in combination with targeted therapies7-9. Furthermore, human brain and lung tumours display robust glucose oxidation by mitochondria10,11. However, it is unclear why a functional ETC is necessary for tumour growth
Inmaculada Martínez-Reyes, Luzivette Robles Cardona, Hyewon Kong, Karthik Vasan, Gregory S. McElroy, Marie Werner, Hermon Kihshen, Colleen R. Reczek, Samuel E. Weinberg, Peng Gao, Elizabeth M. Steinert, Raul Piseaux, G. R. Scott Budinger, Navdeep S. Chandel   +13 more
openaire   +2 more sources

Reduced platelet mitochondrial respiration and oxidative phosphorylation in patients with post COVID-19 syndrome are regenerated after spa rehabilitation and targeted ubiquinol therapy

Frontiers in Molecular Biosciences, 2022
European Association of Spa Rehabilitation recommend spa rehabilitation for patients with post COVID-19 syndrome (post C-19). We studied effects of special mountain spa rehabilitation program and its combination with ubiquinol (reduced form of coenzyme ...
Zuzana Sumbalová, Jarmila Kucharská, Zuzana Rausová, Patrik Palacka, Eleonóra Kovalčíková, Timea Takácsová, Viliam Mojto, Plácido Navas, Guillermo Lopéz-Lluch, Anna Gvozdjáková   +9 more
doaj   +1 more source

Ubiquinol Improves Symptoms in Children with Autism [PDF]

Oxidative Medicine and Cellular Longevity, 2014
Background. Autism is a spectrum of neurodevelopmental disorders with manifestation within 3 years after birth. Manifestations of autism include behavior problems (hyperactivity, toys destruction, self-harm, and agression) and sleep and eating disorders. Etiology of autism is poorly understood.
Anna Gvozdjáková, Jarmila Kucharská, Daniela Ostatníková, Katarína Babinská, Dalibor Nakládal, Fred L. Crane   +5 more
openaire   +3 more sources

Stability of Reduced and Oxidized Coenzyme Q10 in Finished Products

Antioxidants, 2021
The efficiency of coenzyme Q10 (CoQ10) supplements is closely associated with its content and stability in finished products. This study aimed to provide evidence-based information on the quality and stability of CoQ10 in dietary supplements and ...
Žane Temova Rakuša, Albin Kristl, Robert Roškar   +2 more
doaj   +1 more source

The Protective Role of Bioactive Quinones in Stress-induced Senescence Phenotype of Endothelial Cells Exposed to Cigarette Smoke Extract

Antioxidants, 2020
Endothelial dysfunction represents the initial stage in atherosclerotic lesion development which occurs physiologically during aging, but external factors like diet, sedentary lifestyle, smoking accelerate it.
Ilenia Cirilli, Patrick Orlando, Fabio Marcheggiani, Phiwayinkosi V. Dludla, Sonia Silvestri, Elisabetta Damiani, Luca Tiano   +6 more
doaj   +1 more source

Safety Assessment of Ubiquinol Acetate: Subchronic Toxicity and Genotoxicity Studies

Journal of Toxicology, 2019
Coenzyme Q10 (CoQ10) is a lipid soluble, endogenous antioxidant present at highest levels in the heart followed by the kidney and liver. The reduced CoQ10 ubiquinol is well known for its chemical instability and low bioavailability. The present study was
Gajanan Deshmukh, Suresh B. Venkataramaiah, Chandrashekar M. Doreswamy, Mohan C. Umesh, Rajesh B. Subbanna, Bikram K. Pradhan, Srinivas Seekallu, Rajan Sekar, Karthick Prabhu, Sathish Sadagopan, Shri Natrajan Arumugam, Satish Sharma, Govindarajulu Gavara, Selvakumar Balaraman, Ganesh Sambasivam, Ravindra K. Chandrappa, Sarah Flynn, Prasad Shivarudraiah   +17 more
doaj   +1 more source