Results 31 to 40 of about 13,810 (181)

Bioavailability of Coenzyme Q₁₀: An Overview of the Absorption Process and Subsequent Metabolism

Antioxidants, 2020
A lack of understanding of the processes determining the absorption and subsequent metabolism of coenzyme Q10 (CoQ10) has resulted in some manufacturers’ making incorrect claims regarding the bioavailability of their CoQ10 supplements, with potential ...
David Mantle, Alex Dybring
doaj   +1 more source

Bioavailability of Reduced Coenzyme Q10 (Ubiquinol-10) in Burn Patients

Metabolites, 2022
Mitochondrial dysfunction has been implicated in the pathogenesis of inflammation and multi-organ dysfunction in major trauma, including burn injury.
Naohide Kuriyama, Tomoyuki Nakamura, Harumasa Nakazawa, Tyler Wen, Lorenzo Berra, Edward A. Bittner, Jeremy Goverman, Masao Kaneki   +7 more
doaj   +1 more source

Effect of ubiquinol supplementation on biochemical and oxidative stress indexes after intense exercise in young athletes

Redox Report, 2018
Objectives: Physical exercise significantly impacts the biochemistry of the organism. Ubiquinone is a key component of the mitochondrial respiratory chain and ubiquinol, its reduced and active form, is an emerging molecule in sport nutrition.
Patrick Orlando, Sonia Silvestri, Roberta Galeazzi, Roberto Antonicelli, Fabio Marcheggiani, Ilenia Cirilli, Tiziana Bacchetti, Luca Tiano   +7 more
doaj   +1 more source

Intravenous Administration of Coenzyme Q10 in Acute Period of Cerebral Ischemia Decreases Mortality by Reducing Brain Necrosis and Limiting Its Increase within 4 Days in Rat Stroke Model

Antioxidants, 2020
Oxidative stress plays a key role in the pathogenesis of ischemic stroke. Coenzyme Q10 has a multi-targeting effect and may protect the brain against ischemic damage.
Olga N. Obolenskaia, Evgeniya A. Gorodetskaya, Elena I. Kalenikova, Margarita A. Belousova, Mikhail V. Gulyaev, Valery G. Makarov, Yury A. Pirogov, Oleg S. Medvedev   +7 more
doaj   +1 more source

The Protective Effect of Ubiquinone against the Amyloid Peptide in Endothelial Cells Is Isoprenoid Chain Length-Dependent

Antioxidants, 2021
Vascular brain pathology constitutes a common feature in neurodegenerative diseases that could underlie their development. Indeed, vascular dysfunction acts synergistically with neurodegenerative changes to exacerbate the cognitive impairment found in ...
Javier Frontiñán-Rubio, Yoana Rabanal-Ruiz, Mario Durán-Prado, Francisco Javier Alcain   +3 more
doaj   +1 more source

Activity of respiratory chain cytochrome complexes and cytochromes content in the rat kidney mitochondria under different nutrients content in a diet [PDF]

The Ukrainian Biochemical Journal, 2023
An important role in ensuring the functioning of the respiratory chain belongs to the cytochrome part, which includes complexes III (ubiquinol-cytochrome c oxidoreductase) and IV (cytochrome c oxidase). The key components of these enzymatic complexes are
H. P. Kopylchuk, O. M. Voloshchuk
doaj   +1 more source

Effect of gummy candy containing ubiquinol on secretion of saliva: A randomized, double-blind, placebo-controlled parallel-group comparative study and an in vitro study.

PLoS ONE, 2019
A randomized, double-blind, placebo-controlled, parallel-group comparative clinical study was conducted to examine the effects of ubiquinol (the reduced form of Coenzyme Q10) on secretion of saliva.
Ryoko Ushikoshi-Nakayama, Koufuchi Ryo, Tomoe Yamazaki, Mie Kaneko, Tomoko Sugano, Yumi Ito, Naoyuki Matsumoto, Ichiro Saito   +7 more
doaj   +1 more source

Novel Cationic Prodrug of Ubiquinol-10 Enhances Intestinal Absorption via Efficient Formation of Nanosized Mixed-Micelles with Bile Acid Anions

Molecules, 2020
The aim of this study was to develop a prodrug of ubiquinol-10 (UqH-10), the active form of ubiquinone-10 (Uq-10), for oral delivery. Bioavailability of UqH-10 is hampered by its high susceptibility to oxidation and water-insolubility.
Shuichi Setoguchi, Ryoji Hidaka, Nami Nagata-Akaho, Daisuke Watase, Mitsuhisa Koga, Kazuhisa Matsunaga, Yoshiharu Karube, Jiro Takata   +7 more
doaj   +1 more source

The Use of the Coenzyme Q₁₀ as a Food Supplement in the Management of Fibromyalgia: A Critical Review

Antioxidants, 2022
The coenzyme Q10 is a naturally occurring benzoquinone derivative widely prescribed as a food supplement for different physical conditions and pathologies.
Luca Campisi, Concettina La Motta
doaj   +1 more source

Nonoxidizable ubiquinol derivatives that are suitable for the study of the ubiquinol oxidation site in the cytochrome bc1 complex

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2002
Recent X-ray crystallographic analyses of the mitochondrial cytochrome bc1 complex show ubiquinone binding at the Q(i) site, but attempts to show binding of ubiquinol or ubiquinone at the Q(o) site have been unsuccessful, even though the binding of noncompetitive Q(o) site inhibitors near the putative ubiquinol binding pocket is well established.
Zhang, Li, Li, Zhaolong, Quinn, Byron, Yu, Linda, Yu, Chang-An   +4 more
openaire   +2 more sources