Results 31 to 40 of about 25,325 (230)

Bioavailability of Coenzyme Q₁₀: An Overview of the Absorption Process and Subsequent Metabolism

Antioxidants, 2020
A lack of understanding of the processes determining the absorption and subsequent metabolism of coenzyme Q10 (CoQ10) has resulted in some manufacturers’ making incorrect claims regarding the bioavailability of their CoQ10 supplements, with potential ...
David Mantle, Alex Dybring
doaj   +1 more source

Bioavailability of Reduced Coenzyme Q10 (Ubiquinol-10) in Burn Patients

Metabolites, 2022
Mitochondrial dysfunction has been implicated in the pathogenesis of inflammation and multi-organ dysfunction in major trauma, including burn injury.
Naohide Kuriyama, Tomoyuki Nakamura, Harumasa Nakazawa, Tyler Wen, Lorenzo Berra, Edward A. Bittner, Jeremy Goverman, Masao Kaneki   +7 more
doaj   +1 more source

Ubiquinol Reduces Muscle Wasting but Not Fatigue in Tumor-Bearing Mice [PDF]

, 2014
Purpose: Fatigue is the most common and distressing symptom reported by cancer patients during and after treatment. Tumor growth increases oxidative stress and cytokine production, which causes skeletal muscle wasting and cardiac dysfunction. The purpose
Clark, Yvonne, McCarthy, Donna O., Szalacha, Laura A., Wold, Loren E.   +3 more
core   +2 more sources

Intravenous Administration of Coenzyme Q10 in Acute Period of Cerebral Ischemia Decreases Mortality by Reducing Brain Necrosis and Limiting Its Increase within 4 Days in Rat Stroke Model

Antioxidants, 2020
Oxidative stress plays a key role in the pathogenesis of ischemic stroke. Coenzyme Q10 has a multi-targeting effect and may protect the brain against ischemic damage.
Olga N. Obolenskaia, Evgeniya A. Gorodetskaya, Elena I. Kalenikova, Margarita A. Belousova, Mikhail V. Gulyaev, Valery G. Makarov, Yury A. Pirogov, Oleg S. Medvedev   +7 more
doaj   +1 more source

The Protective Effect of Ubiquinone against the Amyloid Peptide in Endothelial Cells Is Isoprenoid Chain Length-Dependent

Antioxidants, 2021
Vascular brain pathology constitutes a common feature in neurodegenerative diseases that could underlie their development. Indeed, vascular dysfunction acts synergistically with neurodegenerative changes to exacerbate the cognitive impairment found in ...
Javier Frontiñán-Rubio, Yoana Rabanal-Ruiz, Mario Durán-Prado, Francisco Javier Alcain   +3 more
doaj   +1 more source

Activity of respiratory chain cytochrome complexes and cytochromes content in the rat kidney mitochondria under different nutrients content in a diet [PDF]

The Ukrainian Biochemical Journal, 2023
An important role in ensuring the functioning of the respiratory chain belongs to the cytochrome part, which includes complexes III (ubiquinol-cytochrome c oxidoreductase) and IV (cytochrome c oxidase). The key components of these enzymatic complexes are
H. P. Kopylchuk, O. M. Voloshchuk
doaj   +1 more source

Alterations of the mitochondrial proteome caused by the absence of mitochondrial DNA: A proteomic view [PDF]

, 2006
The proper functioning of mitochondria requires that both the mitochondrial and the nuclear genome are functional. To investigate the importance of the mitochondrial genome, which encodes only 13 subunits of the respiratory complexes, the mitochondrial ...
Abdul, Appleby, Armstrong, Bai, Bourges, Buchet, Chai, Claros, Da Cruz, Dey, Du, Garcia, Gianazza, Joseph, King, King, Lescuyer, Luche, Manjasetty, Martinus, Perkins, Rabilloud, Rabilloud, Rabilloud, Rabilloud, Rabilloud, Santoni, Sharma, Sharp, Sherer, Singh, Sinha, Suzuki, Tastet, Taylor, Tryoen-Toth, Ugalde, Wiedemann, Zamzami, Zischka   +39 more
core   +4 more sources

Effect of gummy candy containing ubiquinol on secretion of saliva: A randomized, double-blind, placebo-controlled parallel-group comparative study and an in vitro study.

PLoS ONE, 2019
A randomized, double-blind, placebo-controlled, parallel-group comparative clinical study was conducted to examine the effects of ubiquinol (the reduced form of Coenzyme Q10) on secretion of saliva.
Ryoko Ushikoshi-Nakayama, Koufuchi Ryo, Tomoe Yamazaki, Mie Kaneko, Tomoko Sugano, Yumi Ito, Naoyuki Matsumoto, Ichiro Saito   +7 more
doaj   +1 more source

Novel Cationic Prodrug of Ubiquinol-10 Enhances Intestinal Absorption via Efficient Formation of Nanosized Mixed-Micelles with Bile Acid Anions

Molecules, 2020
The aim of this study was to develop a prodrug of ubiquinol-10 (UqH-10), the active form of ubiquinone-10 (Uq-10), for oral delivery. Bioavailability of UqH-10 is hampered by its high susceptibility to oxidation and water-insolubility.
Shuichi Setoguchi, Ryoji Hidaka, Nami Nagata-Akaho, Daisuke Watase, Mitsuhisa Koga, Kazuhisa Matsunaga, Yoshiharu Karube, Jiro Takata   +7 more
doaj   +1 more source

CydDC-mediated reductant export in Escherichia coli controls the transcriptional wiring of energy metabolism and combats nitrosative stress [PDF]

, 2016
The glutathione/cysteine exporter CydDC maintains redox balance in Escherichia coli. A cydD mutant strain was used to probe the influence of CydDC upon reduced thiol export, gene expression, metabolic perturbations, intracellular pH homeostasis, and ...
Cook, Gregory M, Holyoake, Louise V, Howard, Mark J., Hunt, Stuart, Poole, Robert K, Rowe, Michelle L., Sanguinetti, Guido, Shepherd, Mark   +7 more
core   +3 more sources