Ubiquinol decreases monocytic expression and DNA methylation of the pro-inflammatory chemokine ligand 2 gene in humans [PDF]
BMC Research Notes, 2012 Background Coenzyme Q10 is an essential cofactor in the respiratory chain and serves in its reduced form, ubiquinol, as a potent antioxidant. Studies in vitro and in vivo provide evidence that ubiquinol reduces inflammatory processes via gene expression.
Fischer Alexandra +3 more
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Redox Report, 2018 Objectives: Physical exercise significantly impacts the biochemistry of the organism. Ubiquinone is a key component of the mitochondrial respiratory chain and ubiquinol, its reduced and active form, is an emerging molecule in sport nutrition.
Patrick Orlando +7 more
doaj +2 more sources
Ubiquinol Short-Term Supplementation Prior to Strenuous Exercise Improves Physical Performance and Diminishes Muscle Damage [PDF]
Antioxidants, 2023 The benefits of physical exercise on health are diminished when it is non-planned, strenuous, or vigorous, which causes an increase in oxygen consumption and production of free radicals, particularly serious at the muscular level.
Jorge Moreno-Fernandez +10 more
doaj +2 more sources
Effects of Ubiquinol-10 on MicroRNA-146a Expression In Vitro and In Vivo [PDF]
Mediators of Inflammation, 2009 MicroRNAs (miRs) are involved in key biological processes via suppression of gene expression at posttranscriptional levels. According to their superior functions, subtle modulation of miR expression by certain compounds or nutrients is desirable under ...
Constance Schmelzer +6 more
doaj +2 more sources
Safety Assessment of Ubiquinol Acetate: Subchronic Toxicity and Genotoxicity Studies
Journal of Toxicology, 2019 Coenzyme Q10 (CoQ10) is a lipid soluble, endogenous antioxidant present at highest levels in the heart followed by the kidney and liver. The reduced CoQ10 ubiquinol is well known for its chemical instability and low bioavailability. The present study was
Gajanan Deshmukh +17 more
doaj +2 more sources
Superior Anti-arrhythmogenic Effect of Combined Conditioning with Nicotinamide Mononucleotide and Ubiquinol in Myocardial Ischemia/Reperfusion Injury in Aged Rats [PDF]
Advanced Pharmaceutical BulletinPurpose: Lethal ventricular arrhythmias are a significant clinical concern following reperfusion therapies in elderly patients with myocardial infarction.
Behnaz Mokhtari +3 more
doaj +3 more sources
Recent insights into the molecular mechanism of ubiquinol oxidation by cytochrome bc<sub>1</sub>. [PDF]
FEBS Open BioThe review reflects on the mechanism of the catalytic reaction in cytochrome bc1: the electron bifurcation that involves the separation of two electrons derived from the quinol oxidation to opposite sides of the enzyme across the membrane. This review summarizes the long‐standing effort to understand the mechanism of quinol oxidation catalyzed by ...
Wójcik-Augustyn A +2 more
europepmc +2 more sources
Effects of a Semen Extender Treated with Coenzyme Q10-Ubiquinol on the Quality of Thawed Ram Semen [PDF]
, 2023 The study aimed to explore whether the addition of 150μmol/L Coenzyme Q10 - ubiquinol(treatment) to a glycerol extender improved the quality of ram semen cryopreserved when compared to the results for the same extender without the addition of ubiquinol ...
Arroyo, Eduardo
core +1 more source
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease
Hepatology, EarlyView., 2022 RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso +16 more
wiley +1 more source
Role of Coenzyme Q10 in Health and Disease: An Update on the Last 10 Years (2010–2020)
Antioxidants, 2021 The present review focuses on preclinical and clinical studies conducted in the last decade that contribute to increasing knowledge on Coenzyme Q10’s role in health and disease.
Ilenia Cirilli +8 more
doaj +1 more source