Results 41 to 50 of about 13,810 (181)
The Inhibition of Mitochondrial Peroxidation by Ubiquinone and Ubiquinol
Journal of Biological Chemistry, 1966 Ubiquinol-6 (reduced coenzyme Q6) was more effective than ubiquinone-6 and almost as effective as α-tocopherol in reducing the stable free radical diphenyl-p-picrylhydrazyl. The antioxidant activity of ubiquinol-6 was measured at low oxygen concentrations with an oxygen electrode.
A, Mellors, A L, Tappel
openaire +2 more sources
Effects of Ubiquinol-10 on MicroRNA-146a Expression In Vitro and In Vivo
Mediators of Inflammation, 2009 MicroRNAs (miRs) are involved in key biological processes via suppression of gene expression at posttranscriptional levels. According to their superior functions, subtle modulation of miR expression by certain compounds or nutrients is desirable under ...
Constance Schmelzer +6 more
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Frontiers in Cardiovascular Medicine, 2023 Cardiorespiratory function influences exercise capacity and is an important determinant of high-altitude adaptation. Some studies have investigated the characteristics of changes in cardiorespiratory fitness during high-altitude acclimatization. However,
Jie Yang +23 more
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Coenzyme Q10 and Cardiovascular Diseases
Antioxidants, 2021 Coenzyme Q10 (CoQ10), which plays a key role in the electron transport chain by providing an adequate, efficient supply of energy, has another relevant function as an antioxidant, acting in mitochondria, other cell compartments, and plasma lipoproteins ...
Francisco M. Gutierrez-Mariscal +5 more
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Experimental GerontologySupplementation with ubiquinol 10 has been shown to improve the health of experimental animals and elderly individuals. The present study investigated the effects of lifetime supplementation with ubiquinol 10 on the progression of aging and lifespan in ...
Yuichi Igarashi +6 more
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Plasma coenzyme Q10 levels in type 2 diabetic patients with retinopathy [PDF]
International Journal of Ophthalmology, 2013 AIM: To determine the relationship between proliferative diabetic retinopathy (PDRP) and plasma coenzyme Q10(CoQ10) concentration.METHODS: Patients with type 2 diabetes and PDRP were determined to be the case group (n=50).
Orhan Ates +9 more
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Antioxidants, 2022 Propionic acidaemia (PA) is an innate error of metabolism involving a deficiency in the enzyme propionyl-CoA carboxylase. Better control of acute decompensation episodes together with better treatment and monitoring have improved the prognosis of ...
Sinziana Stanescu +6 more
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MiR‐940 Suppresses Ferroptosis by Controlling Expression of Key Regulatory Genes
Advanced Science, EarlyView.A CRISPR‐based screening identified miR‐940 as a critical suppressor of ferroptosis in cancer. By coordinating the downregulation of pro‐ferroptotic genes with the upregulation of GPX4, miR‐940 establishes a regulatory network that protects against ferroptosis and correlates with poor clinical outcomes in distinct cancer entities.
Andrea Kolak +19 more
wiley +1 more source
Antioxidants, 2023 Despite its robust proteopathic nature, the spatiotemporal signature of disrupted protein modules in sporadic Alzheimer’s disease (AD) brains remains poorly understood. This considered oxidative stress contributes to AD progression and early intervention
Emilio Llanos-González +11 more
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Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy
BMEMat, EarlyView.Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu +5 more
wiley +1 more source