Results 41 to 50 of about 16,390 (163)

Coenzyme Q₁₀ and Cardiovascular Diseases

Antioxidants, 2021
Coenzyme Q10 (CoQ10), which plays a key role in the electron transport chain by providing an adequate, efficient supply of energy, has another relevant function as an antioxidant, acting in mitochondria, other cell compartments, and plasma lipoproteins ...
Francisco M. Gutierrez-Mariscal, Silvia de la Cruz-Ares, Jose D. Torres-Peña, Juan F. Alcalá-Diaz, Elena M. Yubero-Serrano, José López-Miranda   +5 more
doaj   +1 more source

Plasma CoQ10 Status in Patients with Propionic Acidaemia and Possible Benefit of Treatment with Ubiquinol

Antioxidants, 2022
Propionic acidaemia (PA) is an innate error of metabolism involving a deficiency in the enzyme propionyl-CoA carboxylase. Better control of acute decompensation episodes together with better treatment and monitoring have improved the prognosis of ...
Sinziana Stanescu, Amaya Belanger-Quintana, Borja Manuel Fernández-Felix, Pedro Ruiz-Sala, Patricia Alcaide, Francisco Arrieta, Mercedes Martínez-Pardo   +6 more
doaj   +1 more source

GHRHR Deficiency Enhances Retinal Ganglion Cell Survival and Visual Functions in Experimental Glaucoma by Inhibiting Ferroptosis

Advanced Science, EarlyView.
Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong, Ming Ho Yam, Jiaxin Zhang, Lin Du, Linbin Zhou, Yolanda Wong Ying Yip, Bo Man Ho, Hemlata Bisnauthsing, Jiahui Li, Ivan Kong, Shushu Xu, Changzhen Fu, Karl K.H. So, Joaquim S.L. Vong, Ling‐Ping Cen, Ming‐Ming Yang, Khazeema Yousaf, Mai Har Sham, Sun On Chan, Poemen P. Chan, Chi Pui Pang, Clement C. Tham, Jing Na He, Jian Li, Wai Kit Chu   +24 more
wiley   +1 more source

Structure of Antimycin A1, a Specific Electron Transfer Inhibitor of Ubiquinol−Cytochrome c Oxidoreductase

, 2016
Structure of Antimycin A1, a Specific Electron Transfer Inhibitor of Ubiquinol−Cytochrome c ...
Hoeon Kim (3006849), Chang-An Yu (546681), Lothar Esser (546679), Josep Rizo (43675), M. Bilayet Hossain (2996259), Di Xia (546683), Dick van der Helm (2949048), Johann Deisenhofer (54414)   +7 more
core   +2 more sources

Plasma coenzyme Q10 levels in type 2 diabetic patients with retinopathy [PDF]

International Journal of Ophthalmology, 2013
AIM: To determine the relationship between proliferative diabetic retinopathy (PDRP) and plasma coenzyme Q10(CoQ10) concentration.METHODS: Patients with type 2 diabetes and PDRP were determined to be the case group (n=50).
Orhan Ates, Habip Bilen, Sadullah Keles, H. Hakan Alp, Mevlüt Sait Keleş, Kenan Yıldırım, Osman Öndaş, L. Can Pınar, Mustafa Civelekler, Orhan Baykal   +9 more
doaj   +1 more source

Spatial and Temporal Protein Modules Signatures Associated with Alzheimer Disease in 3xTg-AD Mice Are Restored by Early Ubiquinol Supplementation

Antioxidants, 2023
Despite its robust proteopathic nature, the spatiotemporal signature of disrupted protein modules in sporadic Alzheimer’s disease (AD) brains remains poorly understood. This considered oxidative stress contributes to AD progression and early intervention
Emilio Llanos-González, Francisco J. Sancho-Bielsa, Javier Frontiñán-Rubio, Yoana Rabanal-Ruíz, Sonia García-Carpintero, Eduardo Chicano, Isabel Úbeda-Banon, Alicia Flores-Cuadrado, Lydia Giménez-Llort, Francisco Javier Alcaín, Juan Ramón Peinado, Mario Durán-Prado   +11 more
doaj   +1 more source

A Novel Reactive Oxygen Species‐Responsive Bone‐Targeted Nanoplatform Based on Cloperastine Attenuates Ovariectomy‐Induced Bone Loss by Inhibiting Osteoclast Oxidative Phosphorylation

Advanced Science, EarlyView.
Cloperastine suppresses osteoclastogenesis by inhibiting PGC1β‐mediated oxidative phosphorylation. Its incorporation into a ROS‐responsive, Asp8‐modified nanoplatform enhances skeletal accumulation. The resulting Clo/Asp8‐PMK‐MCs combine cloperastine‐mediated antiresorptive activity with carrier‐mediated osteogenic activity to attenuate OVX‐induced ...
Haibo Liang, Yong Xiao, Jiangtao Luo, Xiao Yang, Yayun Yang, Qihang Wu, Chenxin Yu, Zhihao Zhou, Xiaoqing Si, Jiansen Miao, Yiting Tu, Qichen Lu, Boreng Qian, Xiangyang Wang, Jiake Xu, Changcan Shi, Haiming Jin   +16 more
wiley   +1 more source

Design, Synthesis, and Photochemical Properties of a Photoreleasable Ubiquinol-2:  A Novel Compound for Studying Rapid Electron-Transfer Kinetics in Ubiquinol-Oxidizing Enzymes

, 2016
The design and multistep convergent synthesis of the novel photoactive ubiquinol-benzoin adduct 1a,b has been accomplished. Optical spectra of the steady-state photolysis reactions showed a smooth conversion from 1a,b to 5,7-dimethoxy-2-phenylbenzofuran (
Sunney I. Chan (817074), Michael H. B. Stowell (3001266), Michael W. Day (1873888), Guangyang Wang (3001269)   +3 more
core   +1 more source

Ubiquinol supplementation in elderly patients undergoing aortic valve replacement: biochemical and clinical aspects. [PDF]

, 2020
Epidemiological data show a rise in the mean age of patients affected by heart disease undergoing cardiac surgery. Senescent myocardium reduces the tolerance to ischemic stress and there are indications about age associated deficit in post-operative ...
Nicolini, F, Orlando, P, Tiano, L, Cirilli, I, Molardi, A, Marcheggiani, F, Dludla, PV, Sabbatinelli, J, Silvestri, S, Nicolini F, Silvestri S, Cirilli I, Sabbatinelli J, Dludla PV, Marcheggiani F, Molardi A, Orlando P, Tiano L   +17 more
core   +2 more sources

COX14 Variants Are Associated With Mitochondrial Complex IV Deficiency Nuclear Type 10 (MC4DN10)

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT COX14 encodes a transmembrane protein essential for cytochrome c oxidase (COX) complex assembly. A homozygous missense variant in COX14 was reported in three siblings from a single consanguineous family with severe, fatal infantile mitochondrial complex IV deficiency nuclear type 10 (MC4DN10; MIM# 619053).
Elias K. Awad, Emily Waskow, Hari Tunuguntla, Joseph Spinner, Hanna J. Tadros, Lisa T. Emrick, Daniel G. Calame, Fernando Scaglia   +7 more
wiley   +1 more source