α-Ketoglutaric acid in Ugi reactions and Ugi/aza-Wittig tandem reactions [PDF]
Beilstein Journal of Organic ChemistryA small library of bis- and tetraamides was synthesized by the Ugi reaction with α-ketoglutaric acid, tert-butyl isocyanide, aromatic aldehydes, and aromatic amines.
Vladyslav O. Honcharov +6 more
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Ugi Four-Component Reactions Using Alternative Reactants
Molecules, 2023 The Ugi four-component reaction (Ugi-4CR) undoubtedly is the most prominent multicomponent reaction (MCRs) that has sparked organic chemists’ interest in the field.
Seyyed Emad Hooshmand, Wei Zhang
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Harnessing unprotected deactivated amines and arylglyoxals in the Ugi reaction for the synthesis of fused complex nitrogen heterocycles [PDF]
Beilstein Journal of Organic ChemistryPiperazines and diazepines are examples of nitrogen heterocycles present in many marketed drugs highlighting their importance in the discovery of novel bioactive compounds.
Javier Gómez-Ayuso +5 more
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Electrochemical TEMPO-Catalyzed Oxidative Ugi-Type Reaction [PDF]
ACS Organic & Inorganic Au, 2021 Oxidative isocyanide-based multicomponent reactions (oxidative IMCRs) are very useful tools for the rapid construction of molecular diversity starting from readily available and stable substrates. Despite all their benefits, such multicomponent reactions are underdeveloped and strictly limited to 3-component processes.
Na Pan +4 more
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Sequential Ugi reaction/base-induced ring closing/IAAC protocol toward triazolobenzodiazepine-fused diketopiperazines and hydantoins [PDF]
Beilstein Journal of Organic Chemistry, 2018 A practical three-step protocol for the assembly of triazolobenzodiazepine-fused diketopiperazines and hydantoins has been developed. The synthesis of these tetracyclic ring systems was initiated by an Ugi reaction, which brought together all necessary ...
Robby Vroemans +7 more
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Unimolecular Exciplexes by Ugi Four-Component Reaction [PDF]
Frontiers in Chemistry, 2019 Exciplex or excited complex emission is an excited state process, arising from considerable charge transfer of an excited energy donor to an acceptor, which can be identified by the occurrence of a redshifted emission band that is absent in the ...
Maria Ochs +3 more
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Two-Step Macrocycle Synthesis by Classical Ugi Reaction. [PDF]
J Org Chem, 2018 The direct nonpeptidic macrocycle synthesis of α-isocyano-ω-amines via the classical Ugi four-component reaction (U-4CR) is introduced. Herein an efficient and flexible two-step procedure to complex macrocycles is reported. In the first step, the reaction between unprotected diamines and isocyanocarboxylic acids gives high diversity of unprecedented ...
Abdelraheem EMM +5 more
europepmc +5 more sources
From Ugi Multicomponent Reaction to Linkers for Bioconjugation [PDF]
ACS Omega, 2020 Bioconjugation is a key approach for the development of novel molecular entities with clinical applications. The biocompatibility and specificity of biomolecules such as peptides, proteins, and antibodies make these macromolecules ideal carriers for selective targeted therapies. In this context, there is a need to develop new molecular units that cover
Iván Ramos-Tomillero +8 more
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N-Hydroxyimide Ugi Reaction toward α-Hydrazino Amides. [PDF]
Org Lett, 2017 The Ugi four-component reaction (U-4CR) with N-hydroxyimides as a novel carboxylic acid isostere has been reported. This reaction provides straightforward access to α-hydrazino amides. A broad range of aldehydes, amines, isocyanides and N-hydroxyimides were employed to give products in moderate to high yields.
Chandgude AL, Dömling A.
europepmc +4 more sources
New tandem Ugi/intramolecular Diels–Alder reaction based on vinylfuran and 1,3-butadienylfuran derivatives [PDF]
Beilstein Journal of Organic ChemistryA new tandem sequence involving the Ugi reaction and Diels–Alder [4 + 2] cycloaddition based on vinylfuran and 1,3-butadienylfuran derivatives was designed and studied.
Yuriy I. Horak +5 more
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