Hydrazine in the Ugi Tetrazole Reaction [PDF]
Synthesis, 2016 We describe the hitherto unknown use of N-Boc-protected hydrazine in the Ugi tetrazole reaction to access a library of highly substituted 5-(hydrazinomethyl)-1-methyl-1H-tetrazoles. The reaction is very versatile and good to high yielding. A one-pot, two-step procedure is given.
Patil +5 more
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Chiral N β-Fmoc-amino alkyl isonitriles in Ugi-4CR: An assembly of novel 1,1â²-iminodicarboxylated peptidomimetics [PDF]
, 2012 Enantiopure N β-Fmoc-amino alkyl isonitriles and amino acid esters have been employed as building blocks in Ugi four-component reaction (U-4CR) to yield 1,1â²-iminodicarboxylated peptidomimetics.
Nagendra, G. +3 more
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Architecturally diverse proteins converge on an analogous mechanism to inactivate Uracil-DNA glycosylase [PDF]
, 2013 Uracil-DNA glycosylase (UDG) compromises the replication strategies of diverse viruses from unrelated lineages. Virally encoded proteins therefore exist to limit, inhibit or target UDG activity for proteolysis.
A. R. Cole +39 more
core +1 more source
Amide-Stabilized Enols in the Enol-Ugi Reaction: A Five-Component Synthesis of Triamides
Chemistry Proceedings, 2021 In continuation with our research in the use of enols in multicomponent reactions with isocyanides (IMCR), for the first time we have used amide-stabilized enols as the acid component in enol-Ugi reactions.
Ana G. Neo +3 more
doaj +1 more source
Diverse Isoquinoline Scaffolds by Ugi/Pomeranz–Fritsch and Ugi/Schlittler–Müller Reactions [PDF]
Organic Letters, 2019 The Pomeranz-Fritsch reaction and its Schlittler-Müller modification were successfully applied in the Ugi postcyclization strategy by using orthogonally protected aminoacetaldehyde diethyl acetal and complementary electron rich building blocks. Several scaffolds, including isoquinolines, carboline, alkaloid-like tetrazole-fused tetracyclic compounds ...
Yuanze Wang +4 more
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Ferrocene-derived P,N ligands : synthesis and application in enantioselective catalysis [PDF]
, 2013 Due to their unique steric and electronic properties, air-stability and modular structure, chiral hybrid P,N-ferrocenyl ligands play a prominent role in the field of asymmetric catalysis.
Noël, Timothy, Van der Eycken, Johan
core +1 more source
Long-range diastereoselectivity in Ugi reactions of 2-substituted dihydrobenzoxazepines
Beilstein Journal of Organic Chemistry, 2011 The Ugi reaction of 2-substituted dihydrobenzoxazepines was found to proceed with unexpectedly good diastereoselectivitiy (diastereoisomeric ratios up to 9:1), despite the large distance between the pre-existing stereogenic centre and the newly generated
Luca Banfi +4 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2016 Herein we describe a versatile approach for the synthesis of acylhydrazino-peptomers, a new class of peptidomimetics. The key idea in this approach is based on a simple route using a one-pot hydrazino-Ugi four-component reaction followed by a ...
Angélica de Fátima S. Barreto +2 more
doaj +1 more source
The CombiUgi Project and Closing the Open Science Loop [PDF]
, 2007 This presentation combines 2 blog posts explaining the CombiUgi project and the predicted anti-tumor activity of a virtual library of 68,000 ...
Dan Zaharevitz +3 more
core +2 more sources
Oxa-Michael/Ugi-Smiles cascade reaction with α,β-unsaturated aldehydes
Results in Chemistry, 2022 Use of α,β-unsaturated aldehydes as components in Ugi-Smiles couplings of 2-nitrophenol with alkyl isocyanides and primary amines provides ready access to γ-alkoxy substituted amides when performed in the presence of alcoholic solvents. The observed five
Aubrey Thessing +5 more
doaj +1 more source