Results 41 to 50 of about 2,950 (153)

Copper‐ and Silver‐Catalyzed Reactions of Active Methylene Isocyanides: Facile Access to Highly Substituted Five‐ and Six‐Membered Heterocycles

Chemistry – A European Journal, EarlyView.
This review summarizes recent advances in copper‐ and silver‐catalyzed reactions of active methylene isocyanides for the synthesis of highly substituted five‐ and six‐membered heterocycles. Emphasis is placed on [3+n] cycloadditions, annulations, and asymmetric strategies, highlighting current limitations and future opportunities in heterocycle ...
Jimil George, Kyungsoo Oh
wiley   +1 more source

Microwave-assisted efficient and facile synthesis of tetramic acid derivatives via a one-pot post-Ugi cascade reaction

Beilstein Journal of Organic Chemistry, 2020
A facile microwave-assisted method for the synthesis of tetramic acid derivatives has been developed through an Ugi/Dieckmann cyclization strategy with DBU.
Yong Li, Zheng Huang, Jia Xu, Yong Ding, Dian-Yong Tang, Jie Lei, Hong-yu Li, Zhong-Zhu Chen, Zhi-Gang Xu   +8 more
doaj   +1 more source

A personal 360° view of applications of ‘biomimetic’ molecular recognition

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract Molecular recognition between biological molecules has formed the basis for innumerable applications in biotechnology for the last seven decades or so. Techniques such as affinity chromatography, solid‐phase and aqueous two‐phase extraction, affinity precipitation, biomimetic catalytic systems, biosensors and molecular imprinting all exploit ...
Christopher R Lowe
wiley   +1 more source

Ugi-Functionalized Magnetic Carbon Quantum Dots: an Efficient and Environmentally Friendly Catalyst for the Synthesis of 1,4-Dihydropyridines

Journal of Science: Advanced Materials and Devices
This research presents the synthesis of Ugi-modified magnetic carbon quantum dots (MCQD-AP-Ugi) via a one-pot process to improve functionality. For the first time, the Ugi reaction was utilized to modify the surface of carbon quantum dots (CQDs), thereby
Faezeh Montazeri, Robabeh Baharfar, Behrooz Maleki   +2 more
doaj   +1 more source

Vedolizumab Induces Remission in Two Cases of Ulcerative Colitis With Upper Gastrointestinal Involvement

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Ulcerative colitis (UC) predominantly affects the colon; upper gastrointestinal involvement (UGI) has been reported, but no established treatments exist. We report two cases of UC with concomitant UGI that showed positive responses to vedolizumab therapy.
Shinya Nakatani, Yuta Yamazaki, Kensuke Higuchi, Yumi Otoyama, Norihiro Suzuki, Kazuo Kikuchi, Takahisa Fujiwara, Atsushi Katagiri, Jyun Ohara, Hitoshi Yoshida   +9 more
wiley   +1 more source

Post-Ugi Cyclization for the Construction of Diverse Heterocyclic Compounds: Recent Updates

Frontiers in Chemistry, 2018
Multicomponent reactions (MCRs) have proved as a valuable tool for organic and medicinal chemist because of their ability to introduce a large degree of chemical diversity in the product in a single step and with high atom economy.
Jitender Bariwal, Rupinder Kaur, Leonid G. Voskressensky, Erik V. Van der Eycken, Erik V. Van der Eycken   +4 more
doaj   +1 more source

Silent Partners in the Mill: Unveiling the Role of Additives in Mechanochemical Synthesis

Chemistry – A European Journal, Volume 32, Issue 9, 2 March 2026.
Mechanochemistry offers a sustainable, solvent‐free alternative to traditional synthesis, often enhanced by additives in a process known as additive‐assisted grinding. This review discusses how various additives, including liquids, ionic solids, and advanced materials like ionic liquids and piezoelectric compounds, improve reaction efficiency ...
Johanna Breinsperger, Nika Podlesnik, Francesco Mele, Michael Schnürch   +3 more
wiley   +1 more source

Distinct by Design: Unraveling the Unique Clinical and Transcriptomic Identity of Juvenile Scleromyositis Overlap Compared to Juvenile Systemic Sclerosis and Juvenile Dermatomyositis: Implications for Care and Pathogenesis

ACR Open Rheumatology, Volume 8, Issue 3, March 2026.
Objective To characterize clinical and transcriptomic differences in juvenile scleromyositis overlap (jOverlap) compared to juvenile systemic sclerosis (jSSc) and juvenile dermatomyositis (JDM), focusing on autoantibody profiles, organ involvement, treatment, and peripheral blood gene expression.
Amanda D. Robinson, Clare E. Pain, Gabrielle A. Morgan, Anwesha Sanyal, Srilakshmi Chaparala, Lauren M. Pachman, Kathryn S. Torok   +6 more
wiley   +1 more source

Cage-like microstructures via sequential Ugi reactions in aqueous emulsions

Beilstein Journal of Organic Chemistry
Cage-like microstructures were obtained in two steps by sequential Ugi reactions. At the first stage, submicron colloidal particles based on carboxymethylcellulose and chitosan with a domain structure were obtained in an aqueous suspension. In the second
Rita S. Alqubelat, Yaroslava A. Menzorova, Maxim A. Mironov   +2 more
doaj   +1 more source

CRISPR Assays for Protein Detection

Chemistry–Methods, Volume 6, Issue 3, March 2026.
This review summarizes recent advances in CRISPR–Cas–based strategies for protein detection. Particular focus is placed on recognition element–based approaches, in which antibodies, aptamers, or DNAzymes convert protein binding into CRISPR‐readable nucleic acid signals, and activity‐based strategies that exploit intrinsic protein functions to trigger ...
Luca Capelli, Elena Spezzani, Dharshini Raghavan, Chiara Micucci, Alessandra Zanut, Alessandro Bertucci   +5 more
wiley   +1 more source