Results 51 to 60 of about 11,747 (233)

Synthesis of beta-lactam peptidomimetics through Ugi MCR: first application of chiral N-beta-Fmoc amino alkyl isonitriles in MCRs [PDF]

, 2011
Chiral N-beta-Fmoc amino alkyl isonitriles were employed in Ugi multi component reactions (Ugi 4C-3CR) to obtain functionalized beta-lactam peptidomimetics with L-aspartic acid alpha-methyl ester/peptide ester and organic aldehydes.
Narendra, N., Sureshbabu, V.V., Vishwanatha, T.M.   +2 more
core   +2 more sources

Substituent Effects in Ugi–Smiles Reactions

The Journal of Physical Chemistry A, 2013
In a recent communication, we described the mechanism of the well-known Ugi-type reactions with a model system (J. Org. Chem. 2012, 77, 1361-1366). Herein, focusing on the Ugi-Smiles coupling, we study the effects of each of the four reactants on the energy profile to further explain the experimental results.
Chéron, Nicolas, Ramozzi, Romain, El Kaim, Laurent, Grimaud, Laurence, Fleurat-Lessard, Paul   +4 more
openaire   +3 more sources

Asymmetric Ugi 3CR on isatin-derived ketimine: synthesis of chiral 3,3-disubstituted 3-aminooxindole derivatives

Beilstein Journal of Organic Chemistry, 2014
An efficient Ugi three-component reaction of a preformed chiral ketimine derived from isatin with various isonitrile and acid components has been developed.
Giordano Lesma, Fiorella Meneghetti, Alessandro Sacchetti, Mattia Stucchi, Alessandra Silvani   +4 more
doaj   +1 more source

Creating CMLReact from UsefulChem Ugi Reactions

, 2008
Cameron, Jean-Claude and I were invited to Peter's place in Cambridge, where we are now hacking on CMLReact for the Ugi reactions Jean-Claude has been working on. I just finished a script that uses the CDK and Sam's interface to the InChI library to convert a list of four reactants and one Ugi product into CMLReact (doi:10.1021/ci0502698).
Egon Willighagen
openalex   +2 more sources

The role of the $P_{11}(1710)$ in the $NN{\to}N{\Sigma}K$ reaction

, 1998
Using the resonance model, which was successfully applied for the study of the $pp{\to}p{\Lambda}K^+$ reaction, we investigate $NN{\to}N{\Sigma}K$ reactions that should provide cleaner information about resonance excitations and meson exchange ...
Cassing, W., Sibirtsev, A., Thomas, A. W., Tsushima, K.   +3 more
core   +1 more source

Endoscopic features of cytomegalovirus disease of the upper gastrointestinal tract between transplant and non-transplant patients [PDF]

The Korean Journal of Internal Medicine
Background/Aims Cytomegalovirus (CMV) disease in the upper gastrointestinal (UGI) tract frequently occurs in immunocompromised patients. However, data regarding UGI CMV disease in non-transplant patients compared with those in transplant recipients are ...
Yuri Kim, Do Hoon Kim, Myeongsook Seo, Hee Kyong Na, Kee Wook Jung, Ji Yong Ahn, Jeong Hoon Lee, Kee Don Choi, Ho June Song, Gin Hyug Lee, Hwoon-Yong Jung   +10 more
doaj   +1 more source

Integrated Ugi-Based Assembly of Functionally, Skeletally, and Stereochemically Diverse 1,4-Benzodiazepin-2-ones [PDF]

, 2015
A practical, integrated and versatile U-4CR-based assembly of 1,4-benzodiazepin-2-ones exhibiting functionally, skeletally, and stereochemically diverse substitution patterns is described.
Abdelaziz El Maatougui, Armando Navarro-Vázquez, Armstrong R. W., Atkins R. J., Azuaje A., Baerends E. J., Bateson A. N., Belvisi L., Bolli M. H., Carlier P. R., Carlier P. R., Christian F. Masaguer, Cuny G., De Clerq E., De Silva R. A., Donald J. R., Dourlat J., Dömling A., Eddy Sotelo, Eichkorn K., Ettari R., Evans B. E., Gilman N. G., Gordon C. P., Guggenhem K. G., He P., Horton D. A., Hsu D. C., Huang Y., Jensen F., Jhonny Azuaje, José Carlos González-Gomez, José M. Pérez-Rubio, Keating T. A., Kleemann A., Kutzelnigg W., Lam P. C. H., Lecinska P., Linscheid P., Lodewyk M. W., Marcaccini S., Marcaccini S., Marta Teijeira, Micale N., Neese F., Petrovich A. G., Sañudo M., Schaefer A., Shaabani A., Shaabani A., Sinnecker S., Smith S. G., Smith S. G., Tempest P., Vicente Yaziji, Vı́ctor M. Sánchez-Pedregal, Weigend F., Xu J., Yang S. K., Zhang Y., Zhu J.   +60 more
core   +6 more sources

Synthesis of Oligo‐Sulfonimidates by Exponential Growth via Sulfur‐Phenolate Exchange Reactions

ChemistryEurope, EarlyView.
A highly flexible iterative exponential growth strategy is used in combination with the sulfur‐phenolate exchange reaction to develop sequence‐defined oligosulfonimidates (16 mer). Combining this with sulfur‐fluorine exchange‐based iterative step growth, a bespoke 20 mer (Mw = 8.5 kDa) can be synthesized.
Yu Han, Dong‐Dong Liang, Silke Heskamp, Bo Chen, Fedor M. Miloserdov, Han Zuilhof   +5 more
wiley   +1 more source

Synthesis of a novel category of pseudo-peptides using an Ugi three-component reaction of levulinic acid as bifunctional substrate, amines, and amino acid-based isocyanides

Beilstein Journal of Organic Chemistry, 2019
The synthesis of a novel category of pseudo-peptides via intramolecular Ugi reaction of levulinic acid (4-oxopentanoic acid), aromatic and aliphatic amines, and amino acid-based isocyanides is reported.
Maryam Khalesi, Azim Ziyaei Halimehjani, Jürgen Martens   +2 more
doaj   +1 more source

Influence of Open Chain and Cyclic Structure of Peptidomimetics on Antibacterial Activity in E. coli Strains

Molecules, 2022
An efficient method for the synthesis of functionalized peptidomimetics via multicomponent Ugi reaction has been developed. The application of trifluoroethanol (TFE) as a reaction medium provided desired products with good yields.
Parul Sahrawat, Paweł Kowalczyk, Dominik Koszelewski, Mateusz Szymczak, Karol Kramkowski, Aleksandra Wypych, Ryszard Ostaszewski   +6 more
doaj   +1 more source