Results 51 to 60 of about 2,950 (153)
Advances of Ugi reaction in natural product synthesis
Green Synthesis and CatalysisThe Ugi multicomponent reaction represents a highly efficient synthetic transformation, wherein all four reactants (isocyanides, amine, aldehyde or ketone and a nucleophile) are combined in one pot under mild conditions. This reaction exhibits remarkable
Wen Zhang +4 more
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Phosphoranaloga von Aminosäuren und Peptiden: β-Lactam-Grundgerüst mit Aminomethylphosphonsäure
CHIMIA, 1984 Syntheses of β-lactams containing aminomethylphosphonate involving the Ugi-reaction of diethylisocyanmethylphosphonate 4 with carbonyl compounds 3 and β-alanine are reported.
Janusz Rachoń
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A Novel Class of Small Molecule Agonists with Preference for Human over Mouse TLR4 Activation. [PDF]
PLoS ONE, 2016 The best-characterized Toll-like receptor 4 (TLR4) ligands are lipopolysaccharide (LPS) and its chemically modified and detoxified variant, monophosphoryl lipid A (MPL).
Jason D Marshall +13 more
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Synthesis, Characterization and Chemistry of Tetrakis(Propargylisocyanide) Copper(I) Complex
Molbank, 2023 The kinetically unstable propargylisocyanide was reacted with the tetrakis(acetonitrile) copper(I) hexafluorophosphate and the formed complex was then involved in a copper-catalyzed alkyne-azide cycloaddition reaction (CuAAC). After the decomplexation of
Alexandre Quelhas +3 more
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Optimizing Benefits‐Harms of H. pylori Screen‐and‐Treat Programs Tailored to the Regional Settings
Helicobacter, Volume 31, Issue 2, March/April 2026.ABSTRACT This article outlines how decision modeling can be used to optimize the cost‐effectiveness of H. pylori screen‐and‐treat programs. Decision models enable the translation of data from pilot studies into locally tailored strategies by adapting test modalities, treatment options, and the need to retest specific to the local setting.
Duco T. Mülder +5 more
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Folia Medica, 2018 Background: Despite the use of traditional method, Ugi reaction currently is a well-established multicomponent reaction. Chromane motif itself possesses a variety of biological functions.
Kapadiya Khushal M. +3 more
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Direct‐to‐Biology: Streamlining the Path From Chemistry to Biology in Drug Discovery
ChemMedChem, Volume 21, Issue 4, 25 February 2026.Crude yet clever: Direct‐to‐biology workflows exploit nanoscale synthesis and plate‐based assays to accelerate hit discovery, save precious intermediates, and rethink early drug discovery. Direct‐to‐biology (D2B) has emerged as a transformative concept in early drug discovery, defined by the direct on‐target screening of crude reaction mixtures without
Ariane F. Hübner, Fabian Barthels
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Cirrhosis of Liver in Patients With Dyskeratosis Congenita: A Report of Two Cases
Clinical Case Reports, Volume 14, Issue 2, February 2026.Classical mucocuaneous triad of dyskeratosis congenita in a patient with decompensated cirrhosis. ABSTRACT Dyskeratosis congenita (DC) is a genetic disorder characterized by multisystem involvement. The most commonly affected systems are the mucocutaneous, bone marrow, and lungs.
Bigyan Maharjan +8 more
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Synthesis of Oligo‐Sulfonimidates by Exponential Growth via Sulfur‐Phenolate Exchange Reactions
ChemistryEurope, Volume 4, Issue 2, February 2026.A highly flexible iterative exponential growth strategy is used in combination with the sulfur‐phenolate exchange reaction to develop sequence‐defined oligosulfonimidates (16 mer). Combining this with sulfur‐fluorine exchange‐based iterative step growth, a bespoke 20 mer (Mw = 8.5 kDa) can be synthesized.
Yu Han +5 more
wiley +1 more source
Recent Contributions of Organic Synthesis to Forensic Science
ChemPlusChem, Volume 91, Issue 2, February 2026.Forensic science is a multidisciplinary field that plays a vital role in providing scientific evidence for criminal investigations. This review highlights advances and opportunities at the interface between organic synthesis and forensic science, with applications in drug identification, forensic toxicology, and latent fingerprint detection and ...
Gustavo dos Santos Martins +3 more
wiley +1 more source