Results 61 to 70 of about 2,950 (153)

Consecutive hydrazino-Ugi-azide reactions: synthesis of acylhydrazines bearing 1,5-disubstituted tetrazoles

Beilstein Journal of Organic Chemistry, 2017
Isocyanide-based multicomponent reactions (IMCRs) allow the construction of relatively complex molecules through a one-pot synthesis. The combination of IMCRs in a consecutive or sequential fashion further extends the complexity of the molecules obtained.
Angélica de Fátima S. Barreto, Veronica Alves dos Santos, Carlos Kleber Z. Andrade   +2 more
doaj   +1 more source

Accelerate the Highly Efficient Development of mRNA Vaccines Through Advanced Computational Methods

MedComm, Volume 7, Issue 2, February 2026.
This review explores the recent advancements in applying computational methods to optimize mRNA vaccines, with a primary focus on improvements in sequence design and delivery systems. ABSTRACT mRNA medicine is an emerging therapeutic approach that utilizes messenger RNA to synthesize functional proteins directly within target cells.
Ruichu Gu, Duanmiao Si, Dingwei Lei, Xiaoxue Xie, Yongge Li, Han Wen   +5 more
wiley   +1 more source

A Comprehensive Review of Adsorbents for Rare Earth Separation: Design, Synthesis, Adsorption Performance, and Mechanisms

Rare Metals, Volume 45, Issue 2, February 2026.
ABSTRACT Rare earth elements (REEs) play an irreplaceable role in modern technology and industry. However, due to the highly similar physicochemical properties among REEs, their separation remains a significant challenge. Additionally, REEs often exist in low‐concentration solutions, making efficient REE recovery an urgent task.
Miao‐Miao Huang, Jun Tan, Liu‐Yin Xia, Kai Han, Hong‐Yan Cai, Xin Ma, Shuai Wang   +6 more
wiley   +1 more source

Payload‐Driven Design of Polymeric Carriers for Nucleic Acid Delivery: Insights from Structure–Function Relationships

Advanced Science, Volume 13, Issue 4, 19 January 2026.
Polymeric carriers provide versatile platforms for nucleic acid delivery. This review introduces a novel perspective inspired by protein structural organization to explore structure–function relationships of polymeric carriers, highlighting requirements of different nucleic acid payloads.
Hanieh Moradian, Charlotte Maeve Dunne, Manfred Gossen, Matthias Hartlieb   +3 more
wiley   +1 more source

Methodologies for Sample Multiplexing and Computational Deconvolution in Single‐Cell Sequencing

Advanced Science, Volume 13, Issue 3, 14 January 2026.
Sample multiplexing offers a critical solution for boosting throughput and minimizing batch effects in single‐cell sequencing. This review navigates the latest experimental methodologies and computational deconvolution algorithms, bridging the gap between wet‐lab design and analytical success.
Yufei Gao, Weiwei Yin, Wei Hu, Wei Chen
wiley   +1 more source

Skeletal Editing of Alkenes with Nitroarenes via Photoinduced Rearrangement of N─O═C Dipoles Forms Lactams and Amides

Advanced Science, Volume 13, Issue 6, 30 January 2026.
Skeletal editing of alkenes via the cascade cleavage of C(sp2)═C(sp2) and C(sp3)─C(sp3) bonds, enabling the insertion of the nitrogen atom and thereby the synthesis of lactam and amide derivatives using nitroarenes as nitrogen atom insertion reagents under light irradiation.
Hongyun Qin, Zemin Wang, Cong Shi, Jiashu Chen, Chao Liu, Xiangqian Li, Ruihua Liu, Dayong Shi   +7 more
wiley   +1 more source

Convergent synthesis of 13N-labelled Peptidic structures using aqueous [13N]NH3

EJNMMI Radiopharmacy and Chemistry, 2017
Background Nitrogen-13 has a 10-min half-life which places time constraints on the complexity of viable synthetic methods for its incorporation into PET imaging agents.
Julia E. Blower, Samuel F. Cousin, Antony D. Gee   +2 more
doaj   +1 more source

Ugi bisamides based on pyrrolyl-β-chlorovinylaldehyde and their unusual transformations

Beilstein Journal of Organic Chemistry
By one-pot four- and three-component Ugi reactions involving convertible isocyanides and unexplored pyrrole-containing β-chlorovinylaldehyde, a small library of 20 bisamides with unusual behavior in post-Ugi transformations was prepared and characterized.
Alexander V. Tsygankov, Vladyslav O. Vereshchak, Tetiana O. Savluk, Serhiy M. Desenko, Valeriia V. Ananieva, Oleksandr V. Buravov, Yana I. Sakhno, Svitlana V. Shishkina, Valentyn A. Chebanov   +8 more
doaj   +1 more source

Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction

Beilstein Journal of Organic Chemistry, 2019
Substituted 1H-pyrazolo[3,4-b]pyridine-4- and 1H-pyrazolo[3,4-b]pyridine-6-carboxamides have been synthetized through a Doebner–Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination ...
Maryna V. Murlykina, Oleksandr V. Kolomiets, Maryna M. Kornet, Yana I. Sakhno, Sergey M. Desenko, Victoriya V. Dyakonenko, Svetlana V. Shishkina, Oleksandr A. Brazhko, Vladimir I. Musatov, Alexander V. Tsygankov, Erik V. Van der Eycken, Valentyn A. Chebanov   +11 more
doaj   +1 more source

Synthesis of Polyheterocyclic Pyrrolo[3,4-b]pyridin-5-ones via a One-Pot (Ugi-3CR/aza Diels-Alder/N-acylation/aromatization/SN2) Process. A Suitable Alternative towards Novel Aza-Analogues of Falipamil

Molecules, 2018
We describe the one-pot synthesis of twenty polyheterocyclic pyrrolo[3,4-b]pyridin-5-ones via a cascade process (Ugi-3CR/aza Diels-Alder/N-acylation/aromatization) in 20 to 95% overall yields, as well as four pharmacologically promising analogues via an ...
Angel Zamudio-Medina, Ailyn N. García-González, Genesis K. Herrera-Carrillo, Daniel Zárate-Zárate, Adriana Benavides-Macías, Joaquín Tamariz, Ilich A. Ibarra, Alejandro Islas-Jácome, Eduardo González-Zamora   +8 more
doaj   +1 more source