Mutation of the highly conserved amino acids in the N-terminal region of the EV-A71 VP1 protein impairs viral RNA release during virus entry [PDF]
Microbiology SpectrumEnterovirus A71 (EV-A71) causes hand-foot-mouth disease, which may progress to severe neurological and systemic complications in young children and infants.
Wenjing Zhang +15 more
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SUMOylation-dependent degradation of nucleocapsid is responsible for Pestivirus uncoating [PDF]
Journal of VirologyClassical swine fever virus (CSFV), a highly virulent member of the Pestivirus genus, is one of the most significant pathogens within this group. Although uncoating is a prerequisite for productive infection, the molecular determinants orchestrating this
Lin-Ke Zou +10 more
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A Prediction Model for Uncoating Receptor Usage in Human Enteroviruses Based on Amino Acid Sequences and a Naive Bayes Algorithm [PDF]
VirusesThis study constructed a bioinformatics prediction algorithm for human enterovirus uncoating receptors based on amino acid sequences and physicochemical properties.
Yongtao Jia +3 more
doaj +2 more sources
Nsp2 replicase-mediated viral uncoating in porcine alveolar macrophages contributes to the attenuation of PRRSV-2 live attenuated vaccine [PDF]
Journal of VirologyType 2 porcine reproductive and respiratory syndrome virus (PRRSV-2) poses a major threat to global swine production. While live attenuated vaccines (LAVs) remain the most effective countermeasure, the molecular mechanisms underlying PRRSV-2 attenuation ...
Yuan-Zhe Bai +13 more
doaj +2 more sources
Adducin‐1 Facilitates Influenza Virus Endosomal Trafficking and Uncoating by Regulating Branched Actin Dynamics and Myosin IIB Activity [PDF]
Advanced ScienceActin‐ and microtubule‐based transport systems are essential for the trafficking of endocytic viruses and cargoes. Microtubules facilitate long‐distance transport; however, the precise role of actin dynamics and its regulators during virus entry ...
Meijun Jiang +10 more
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The Role of Capsid in HIV-1 Nuclear Entry
Viruses, 2021 HIV-1 can infect non-dividing cells. The nuclear envelope therefore represents a barrier that HIV-1 must traverse in order to gain access to the host cell chromatin for integration.
Anabel Guedán +3 more
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Fluorescent image analysis of HIV-1 and HIV-2 uncoating kinetics in the presence of old world monkey TRIM5α. [PDF]
PLoS ONE, 2015 Uncoating of Human Immunodeficiency Virus type 1 (HIV-1) and type 2 (HIV-2) conical cores is an important early step for establishment of infection.
Eri Takeda +5 more
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Overlap Intensity: An ImageJ Macro for Analyzing the HIV-1 In Situ Uncoating Assay
Viruses, 2021 Capsid uncoating is at the crossroads of early steps in HIV-1 replication. In recent years, the development of novel assays has expanded how HIV-1 uncoating can be studied.
Zachary Ingram +4 more
doaj +1 more source
Characterization of HIV-1 uncoating in human microglial cell lines
Virology Journal, 2020 Background After viral fusion with the cell membrane, the conical capsid of HIV-1 disassembles by a process called uncoating. Previously we have utilized the CsA washout assay, in which TRIM-CypA mediated restriction of viral replication is used to ...
Zachary Ingram +4 more
doaj +1 more source
eLife, 2021 High-resolution imaging techniques reveal new insights into the actions of the retrovirus HIV-1 inside host cells.
Gregory J Bedwell, Alan N Engelman
doaj +1 more source