Results 101 to 110 of about 24,862 (198)
A circular uncoating mechanism [PDF]
The Journal of Cell Biology, 2003 ![Graphic][1] High curvature on smaller vesicles speeds hydrolysis of Arf1-GTP. Antonny/MacmillanIn retrospect it seems obvious. If you need to uncoat a vesicle only after the vesicle has formed, use the spherical shape of the vesicle as a trigger for uncoating. Now, Joelle Bigay,
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IP6 Regulation of HIV Capsid Assembly, Stability, and Uncoating
Viruses, 2018 The mechanisms that drive formation of the HIV capsid, first as an immature particle and then as a mature protein shell, remain incompletely understood.
Robert A. Dick +3 more
doaj +1 more source
Clathrin uncoating: Auxilin comes to life [PDF]
Current Biology, 2001 The DnaJ protein auxilin has been extensively studied in vitro as a cofactor for uncoating clathrin-coated vesicles by the chaperone Hsc70. Recent studies provide the first evidence that auxilin plays this role in vivo, and work on a new mammalian auxilin suggests the protein may have more complex cellular functions.
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A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study
Advanced Biology, Volume 9, Issue 12, December 2025.Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers +10 more
wiley +1 more source
Viruses, 2015 Viruses that specifically replicate in tumor over normal cells offer promising cancer therapies. Oncolytic viruses (OV) not only kill the tumor cells directly; they also promote anti-tumor immunotherapeutic responses.
Adil Mohamed +2 more
doaj +1 more source
Monitoring dynamics of human adenovirus disassembly induced by mechanical fatigue [PDF]
, 2013 The standard pathway for virus infection of eukaryotic cells requires disassembly of the viral shell to facilitate release of the viral genome into the host cell.
de Pablo, Pedro José +5 more
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Advanced Science, Volume 12, Issue 48, December 29, 2025.The precise regulation of AP2M1 is essential for normal hematopoiesis. Overexpression of AP2M1 negatively affects the clinical outcomes of AML patients. Upregulation of AP2M1 enhances stemness and chemoresistance in HSPC cells of AML. AP2M1 modulates NOTCH1 expression, enhancing the Notch1 signaling pathway.
Hansong Lee +28 more
wiley +1 more source
mBio, 2018 Once HIV-1 enters a cell, the viral core is uncoated by a poorly understood mechanism and the HIV-1 genomic RNA is reverse transcribed into DNA. Host cell factors are essential for these processes, although very few reverse transcription complex binding ...
Daniel J. Rawle +5 more
doaj +1 more source
Virion structure and genome delivery mechanism of sacbrood honeybee virus [PDF]
, 2018 Infection by sacbrood virus (SBV) from the family Iflaviridae is lethal to honey bee larvae but only rarely causes the collapse of honey bee colonies. Despite the negative effect of SBV on honey bees, the structure of its particles and mechanism of its ...
Füzik, Tibor +6 more
core +1 more source
Modulation of host cell pathways by Coxiella burnetii Dot/Icm effectors
mLife, Volume 4, Issue 6, Page 577-596, December 2025.Abstract Coxiella burnetii, the etiological agent of Q fever, is a significant intracellular bacterial pathogen. C. burnetii is a highly infectious pathogen that primarily targets pulmonary alveolar macrophages during natural infection. It can then disseminate to macrophages in other tissues and organs, leading to chronic infections. C.
Jingya Yuan +3 more
wiley +1 more source