Results 31 to 40 of about 24,862 (198)
Localization and functions of native and eGFP-tagged capsid proteins in HIV-1 particles.
PLoS Pathogens, 2022 In infectious HIV-1 particles, the capsid protein (CA) forms a cone-shaped shell called the capsid, which encases the viral ribonucleoprotein complex (vRNP).
Ashwanth C Francis +7 more
doaj +1 more source
VP5* Rearranges when Rotavirus Uncoats [PDF]
Journal of Virology, 2009 ABSTRACT Trypsin primes rotavirus for efficient infectivity by cleaving the spike protein, VP4, into VP8* and VP5*. A recombinant VP5* fragment has a trimeric, folded-back structure. Comparison of this structure with virion spikes suggests that a rearrangement, analogous to those of enveloped virus fusion proteins, may mediate membrane ...
Joshua D, Yoder +7 more
openaire +2 more sources
The role of cellular adhesion molecules in virus attachment and entry [PDF]
, 2015 As obligate intracellular parasites, viruses must traverse the host-cell plasma membrane to initiate infection. This presents a formidable barrier, which they have evolved diverse strategies to overcome.
Bhella, David
core +1 more source
Uncoating of non-enveloped viruses [PDF]
Current Opinion in Virology, 2013 Non-enveloped viruses enclose their genome in capsids built of repetitive polypeptides interlinked with cementing proteins, divalent cations or disulphides. Interactions are broken in a stepwise manner during entry into cells leading to genome uncoating. Receptor or proteases induce conformational changes in case of rhinovirus, poliovirus or adenovirus,
Suomalainen Maarit, Greber Urs F
openaire +3 more sources
Real-time Fluorescence Measurement of Enterovirus Uncoating
Bio-Protocol, 2020 Viruses need to open, i.e., uncoat, in order to release their genomes for efficient replication and translation. Especially for non-enveloped viruses, such as enteroviruses, the cues leading to uncoating are less well known.
Visa Ruokolainen +2 more
doaj +1 more source
eLife, 2021 HIV-1 replication commences inside the cone-shaped viral capsid, but timing, localization, and mechanism of uncoating are under debate. We adapted a strategy to visualize individual reverse-transcribed HIV-1 cDNA molecules and their association with ...
Thorsten G Müller +9 more
doaj +1 more source
Viruses, 2020 An assembly of capsid proteins (CA) form the mature viral core enclosing the HIV-1 ribonucleoprotein complex. Discrepant findings have been reported regarding the cellular sites and the extent of core disassembly (uncoating) in infected cells.
Ashwanth C. Francis +4 more
doaj +1 more source
HIV-1 Capsid Core: A Bullet to the Heart of the Target Cell
Frontiers in Microbiology, 2021 The first step of the intracellular phase of retroviral infection is the release of the viral capsid core in the cytoplasm. This structure contains the viral genetic material that will be reverse transcribed and integrated into the genome of infected ...
Elenia Toccafondi +2 more
doaj +1 more source
A Spotlight on Viruses—Application of Click Chemistry to Visualize Virus-Cell Interactions
Molecules, 2019 The replication of a virus within its host cell involves numerous interactions between viral and cellular factors, which have to be tightly controlled in space and time.
Thorsten G. Müller +2 more
doaj +1 more source
Regaining the FORS: optical ground-based transmission spectroscopy of the exoplanet WASP-19b with VLT+FORS2 [PDF]
, 2015 In the past few years, the study of exoplanets has evolved from being pure discovery, then being more exploratory in nature and finally becoming very quantitative. In particular, transmission spectroscopy now allows the study of exoplanetary atmospheres.
Ancker, M. E. Van den +6 more
core +2 more sources