Results 131 to 140 of about 73,799 (284)

Brown adipocytes prevent kidney stone formation via heat-producing protein, uncoupling protein 1

open access: yesEuropean Urology Open Science, 2020
T. Sugino   +10 more
doaj   +1 more source

A Modular PLUG‐IN Photosynthetic Chassis With Tunable Thermal Control for Mammalian Systems

open access: yesAdvanced Science, EarlyView.
This work establishes a “plug‐in” chassis compatible with mammalian systems that synchronizes growth, production, and cell‐wall re‐configuration, providing a versatile platform for photosynthetic bioproduction and microalgal synthetic biology. ABSTRACT Microalgae are promising photosynthetic platforms for high‐value compounds, yet their industrial use ...
Qinhua Gan   +13 more
wiley   +1 more source

Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma

open access: yes, 2015
Whereas uncoupling protein 1 (UCP-1) is clearly involved in thermogenesis, the role of UCP-2 is less clear. Using hybridization, cloning techniques and cDNA array analysis to identify inducible neuroprotective genes, we found that neuronal survival ...
Tomasevic, G   +11 more
core   +2 more sources

Uncoupling protein-4 (UCP4) increases ATP supply by interacting with mitochondrial complex II in neuroblastoma cells [PDF]

open access: yes, 2012
Mitochondrial uncoupling protein-4 (UCP4) protects against Complex I deficiency as induced by 1-methyl-4-phenylpyridinium (MPP +), but how UCP4 affects mitochondrial function is unclear.
Michelle Hiu-Wai Kung   +30 more
core   +1 more source

A Biomimetic Dual‐Targeting Nano‐APA‐Editor Reprograms the 3'UTR Landscape for Tongue Squamous Cell Carcinoma Therapy

open access: yesAdvanced Science, EarlyView.
This study unveils a pathogenic axis in oral cancer where NUDT21 suppresses a tumor suppressor network, prominently PTEN, via 3'UTR lengthening. To exploit this transcriptomic vulnerability, we developed a biomimetic Nano‐APA‐editor. By delivering CRISPR/Cas9, we reprogrammed the global 3'UTR landscape, restoring multi‐target tumor suppression and ...
Yiran Ao   +5 more
wiley   +1 more source

Comparative study on the thermogenic mechanism in two rodents, Eothenomys milletus and Apodemus chevrieri in Hengduan Mountain region during cold exposure [PDF]

open access: yesJournal of Stress Physiology & Biochemistry, 2012
The thermogenic mechanisms were measured in the two small rodents, Eothenomys milletus and Apodemus chevrieri in Hengduan mountain region during cold exposure. The main results were as follows: 1.
Zhu Wan-long, Wang Zheng-kun
doaj  

Possibilities of UCP2 (uncoupling protein 2) induction in rat hepatocytes in in vivo conditions [PDF]

open access: yes, 2012
Possibilities of UCP2 (uncoupling protein 2) induction in rat hepatocytes in in vivo conditions Introduction Uncoupling protein 2, discovered in 1997, is the first described homologue of uncoupling protein 1. Uncoupling proteins increase the permeability
Bolehovská, Radka
core  

Role of F1F0-ATP synthase and uncoupling protein in mitochondrial respiratory uncoupling of ripened avocado fruits

open access: yes, 2015
The present study was carried out to determine the contribution of the F-1 F-0-ATP synthase, the ATP/ADP carrier (AAC) and a putative plant uncoupling mitochondrial protein (PUMP) to the increased respiratory activity of ripened avocado fruits.
Saviani, EE, da Silva, A, Martins, IS
core   +1 more source

Antigen Spreading via Localized Administration Enhances Adoptive TCR‐T Cell Therapy in Pancreatic Cancer

open access: yesAdvanced Science, EarlyView.
Cancer vaccines face limitations in pancreatic cancer due to insufficient tumor antigens. This ionic liquid ILvax via local tumor delivery triggers robust cDC1‐dependent systemic anti‐tumor immunity. It boosts endogenous CD8+ T cells and optimizes adoptive TCR‐T function, providing a promising synergistic therapeutic strategy.
Junming Huang   +11 more
wiley   +1 more source

The UCP2/PINK1/LC3b-mediated mitophagy is involved in the protection of NRG1 against myocardial ischemia/reperfusion injury

open access: yesRedox Biology
Available evidence indicates that neuregulin-1 (NRG-1) can provide a protection against myocardial ischemia/reperfusion (I/R) injury and is involved in various cardioprotective interventions by potential regulation of mitophagy.
Xin-Tao Li   +9 more
doaj   +1 more source

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