Results 141 to 150 of about 73,799 (284)

Regulation of insulin secretion by uncoupling protein

, 2006
UCPs (uncoupling proteins) can regulate cellular ATP production by uncoupling oxidative phosphorylation. UCP2 is expressed in islet beta-cells and its induction reduces glucose-stimulated insulin secretion.

core   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source

MKK6 controls T3-mediated browning of white adipose tissue

Nature Communications, 2017
Brown and beige adipose tissues dissipate heat via uncoupling protein 1 (UCP1). Here the authors show that the stress activated kinase MKK6 acts as a repressor of UCP1 expression, suggesting that its inhibition promotes adipose tissue browning and ...
Nuria Matesanz, Edgar Bernardo, Rebeca Acín-Pérez, Elisa Manieri, Sonia Pérez-Sieira, Lourdes Hernández-Cosido, Valle Montalvo-Romeral, Alfonso Mora, Elena Rodríguez, Luis Leiva-Vega, Ana Victoria Lechuga-Vieco, Jesús Ruiz-Cabello, Jorge L. Torres, Maria Crespo-Ruiz, Francisco Centeno, Clara V. Álvarez, Miguel Marcos, Jose Antonio Enríquez, Ruben Nogueiras, Guadalupe Sabio   +19 more
doaj   +1 more source

Efeito da diabetes mellitus tipo 1 na função mitocondrial

, 2011
Mestrado em Bioquímica-Métodos BiomulecularesDespite type 1 diabetes mellitus being more rare, it has an autoimmune origin and appears early in life, greatly affecting its quality.
Carvalho, Tiago Filipe Cruz
core  

Uncoupling protein 2 and islet function

Stressors such as chronic hyperglycemia or hyperlipidemia may lead to insufficient insulin secretion in susceptible individuals, contributing to type 2 diabetes. The molecules mediating this effect are just beginning to be identified. Uncoupling protein (

core   +1 more source

Lactate‐Driven Restriction of Mitochondrial Permeability Transition Promotes Resistance to Chemo‐Immunotherapy by Suppressing Tumor PANoptosis

Advanced Science, EarlyView.
Tumor‐derived lactate establishes a metabolic lock that drives chemo‐immunotherapy resistance by suppressing PANoptosis. Mechanistically, KAT8 lactylates the mitochondrial translocator ANT2, which recruits PGAM5 to dephosphorylate CypD. This cascade restricts mitochondrial permeability transition pore opening, preventing pro‐inflammatory mtDNA leakage.
Sen Zhong, Wenlong Chen, Fanglong Liu, Shengyi Zhou, Bolin Yu, Yuying Wang, Xiqian Zhou, Xuehui Wang, Diya Liu, Zhuoyu Zhang, Xinran Wang, Mounia Lalouly, Yiwen Li, Zhefei Du, Tao Yan, Zhihui Xiao, Zhou Zhou, Huanhuan Zhu, Fengyuan Qian, Bowen Zheng, Lin Fang   +20 more
wiley   +1 more source

CTRP9 Promotes Brown Adipose Tissue Lipolysis in Mice Fed a High-Fat Diet

Frontiers in Bioscience-Landmark
Background: This study aimed to elucidate the molecular mechanism through which C1q/tumor necrosis factor (TNF)-related protein 9 (CTRP9) acts in the formation and differentiation of brown adipose tissue (BAT).
Hua Guan, Le Wang, Zhanyi Geng, Bowen Duan, Yang Gao, Zheyong Liang, Xinglong Zheng, Tao Shi, Fengwei Guo   +8 more
doaj   +1 more source

Loss of Uncoupling Protein 1 Expression in the Subcutaneous Adipose Tissue Predicts Childhood Obesity. [PDF]

Int J Mol Sci, 2023
Gyurina K, Yarmak M, Sasi-Szabó L, Molnár S, Méhes G, Röszer T.   +5 more
europepmc   +1 more source

Effect of cold acclimation on cell morphology and uncoupling protein 1 expression in adipose tissues.

, 2013
Mice were housed in a cold environment (10°C; cold-acclimated mice) or a control environment (24°C; control mice) for 3 weeks. (A) Sections of interscapular brown adipose tissue (BAT), inguinal white adipose tissue (WAT) (I-WAT), and perigonadal WAT (G ...
Yuko Okamatsu-Ogura (205829), Akihiro Uozumi (503366), Masayuki Saito (205833), Ayumi Tsubota (503365), Kazuhiro Kimura (205831), Keigo Fukano (503364), Akira Terao (503367)   +6 more
core   +1 more source