Results 161 to 170 of about 69,972 (249)

Structure and regulatory mechanism of human uncoupling protein 1

Uncoupling protein 1 (UCP1) in the mitochondrial inner membrane is responsible for the thermogenic properties of brown adipose tissue. In response to cold exposure, UCP1 is activated by free fatty acids and catalyses proton leak, dissipating the proton motive force, which mitochondria use to drive ATP synthesis.
openaire   +2 more sources

Brown Adipose Tissue—A Therapeutic Target in Obesity?

Frontiers in Physiology, 2018
Paul Trayhurn, Paul Trayhurn
doaj   +1 more source

A possibility of uncoupling protein 1 induction with the enhancement of myogenesis related to ruminal fermentation. [PDF]

Sci Rep
Diao Z, Jia S, Itoyama E, Yoshioka H, Murakami M, Funaba M.   +5 more
europepmc   +1 more source

Exposure to PCB52 (2,2',5,5'-tetrachlorobiphenyl) blunts induction of the gene for uncoupling protein 1 (UCP1) in white adipose. [PDF]

Environ Toxicol Pharmacol
Gourronc FA, Bullert AJ, Helm-Kwasny BK, Adamcakova-Dodd A, Wang H, Jing X, Li X, Thorne PS, Lehmler HJ, Ankrum JA, Klingelhutz AJ.   +10 more
europepmc   +1 more source

Anti-Obesity Effects of Artemisia annua Extract in Zucker Fatty Rats and High-Fat Diet Sprague Dawley Rats through Upregulation of Uncoupling Protein 1. [PDF]

J Obes Metab Syndr, 2021
Choi EY, Park CY, Ho SH, Park SJ, Kim D, Han B, Kim SH.   +6 more
europepmc   +1 more source

Correction: Keys to the switch of fat burning: stimuli that trigger the uncoupling protein 1 (UCP1) activation in adipose tissue. [PDF]

Lipids Health Dis
Gong D, Lei J, He X, Hao J, Zhang F, Huang X, Gu W, Yang X, Yu J.   +8 more
europepmc   +1 more source

Strategies and mechanisms of precision genome engineering: From gene editing to genome writing

iMetaOmics, EarlyView.
In this review, we examined the progression of genome manipulation from stochastic nuclease‐mediated cutting toward precise editing and programmable genome writing. We discussed tools like multi‐kilobase RNA‐guided integrators and Artificial Intelligence (AI)‐designed effectors and showed how these advances enable researchers to treat genomes as ...
Kerui Huang, Jianhong Tian, Wenyan Zhao, Siqin Zhang, Lixuan Xiang, Meiqing Yang, Lu Liu, Yazhou Huang, Ningyun Zhang, Lei Sun, Peng Xie, Nanyu Kuang, Hong Zhou, Chengfeng Qiu, Jun Yan, Xiaocheng Jiang, Qiang Tu, Yun Wang, Haoliang Hu, Youming Zhang   +19 more
wiley   +1 more source

Keys to the switch of fat burning: stimuli that trigger the uncoupling protein 1 (UCP1) activation in adipose tissue. [PDF]

Lipids Health Dis
Gong D, Lei J, He X, Hao J, Zhang F, Huang X, Gu W, Yang X, Yu J.   +8 more
europepmc   +1 more source

Localization of uncoupling protein 1 (UCP-1) in the sebaceous gland of the dorsal region in the Sunda porcupine (Hystrix javanica). [PDF]

J Vet Med Sci, 2020
Prawira AY, Novelina S, Farida WR, Darusman HS, Warita K, Agungpriyono S, Hosaka YZ.   +6 more
europepmc   +1 more source

Maternal and infant gut microbiome

iMeta, EarlyView.
The maternal–infant continuum involves critical windows of host–microbiota co‐adaptation. Preconception, maternal and paternal microbiomes modulate immunity and reproduction. During pregnancy, a gut–placenta axis emerges, where microbial metabolites influence fetal growth or contribute to complications like gestational diabetes mellitus (GDM ...
Huidi Wang, Felicia Tin, Hui Chen, Fuxin Jiao, Min Wu, Shanshan Sun, Lisha Lin, Die Li, Huimin Zheng, Zhenxin Niu, Mengyao Lan, Bahtiyar Yilmaz, Johan G. Eriksson, Mengjia Wang, Andrew Macpherson, Jose C. Clemente, Jia Xu, Ri‐hua Xie, Xiaojiao Zheng, Tao Zhou, Jinfeng Wang, Wei Shen, Bing Huang, Xia Chen, Hai Li, Yan He   +25 more
wiley   +1 more source