Results 141 to 150 of about 1,699,867 (343)
Mapping the Nucleotide Binding Site of Uncoupling Protein 1 Using Atomic Force Microscopy
Journal of the American Chemical Society, 2013 A tight regulation of proton transport in the inner mitochondrial membrane is crucial for physiological processes such as ATP synthesis, heat production, or regulation of the reactive oxygen species as proposed for the uncoupling protein family members ...
R. Zhu +6 more
semanticscholar +1 more source
Structural mechanisms of mitochondrial uncoupling protein 1 regulation in thermogenesis
Trends in Biochemical SciencesIn mitochondria, the oxidation of nutrients is coupled to ATP synthesis by the generation of a protonmotive force across the mitochondrial inner membrane. In mammalian brown adipose tissue (BAT), uncoupling protein 1 (UCP1, SLC25A7), a member of the SLC25 mitochondrial carrier family, dissipates the protonmotive force by facilitating the return of ...
Scott A. Jones +3 more
openaire +4 more sources
Advanced Science, EarlyView.This study develops a human engineered heart tissue‐derived model of diabetic cardiomyopathy that accurately replicates the dynamic changes in the structural, contractile, and electrophysiological properties of the myocardium. Furthermore, this model is used to confirm the direct protective effects of empagliflozin on the heart through an SGLT2 off ...
Lin Cai +9 more
wiley +1 more source
Arquivos brasileiros de endocrinologia e metabologia, 2012 It is well established that genetic factors play an important role in the development of both type 2 diabetes mellitus (DM2) and obesity, and that genetically susceptible subjects can develop these metabolic diseases after being exposed to environmental ...
L. Brondani +5 more
semanticscholar +1 more source
Living unicellular eukaryote Tetrahymena pyriformis as a model for study [PDF]
, 2011 Some animals are able to survive for a long time under conditions of drastically reduced oxidative metabolism, called metabolic depression. The most investigated type of metabolic depression is hibernation.
Elena Mokhova, Elena Mokhova
core +3 more sources
SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy
Advanced Science, EarlyView.During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong +9 more
wiley +1 more source
Balancing noise and plasticity in eukaryotic gene expression [PDF]
, 2012 Coupling the control of expression stochasticity (noise) to the ability of expression change (plasticity) can alter gene function and influence adaptation.
Bajić, Djordje, Poyatos, Juan F.
core +4 more sources
Mitigating Cell Cycle Effects in Multi‐Omics Data: Solutions and Analytical Frameworks
Advanced Science, EarlyView.The study highlights the cell‐cycle effects on multi‐omics analysis attributed to varying cell cycle compositions across cell types. To minimize the influence, we propose RTD correction in CNV calling with a high S‐phase ratio, and phase comparison in chromatin accessibility, DNA methylation, and transcriptomics.
Rui Nie +7 more
wiley +1 more source
مجله علوم پزشکی فیض (پیوسته)Background and Aim: Obesity and overweight are recognized as major risk factors for many diseases. The aim of this study was to determine the effect of eight weeks of resistance training on the expression of apelin and uncoupling protein-1 (UCP1) genes ...
Fateme Sadat Shahabpoor +2 more
doaj
A new thiazolidinedione, NC-2100, which is a weak PPAR-gamma activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice. [PDF]
, 2000 Yuka Fukui +4 more
openalex +1 more source