Results 51 to 60 of about 1,699,867 (343)

Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy. [PDF]

, 2014
Contraction in the mammalian heart is controlled by the intracellular Ca2+ concentration as it is in all striated muscle, but the heart has an additional signalling system that comes into play to increase heart rate and cardiac output during exercise or ...
Marston, SB, Messer, AE
core   +2 more sources

The complementary and divergent roles of uncoupling proteins 1 and 3 in thermoregulation [PDF]

The Journal of Physiology, 2016
Key points Both uncoupling protein 1 (UCP1) and UCP3 are important for mammalian thermoregulation. UCP1 and UCP3 in brown adipose tissue mediate early and late phases of sympathomimetic thermogenesis, respectively. Lipopolysaccharide thermogenesis requires skeletal muscle UCP3 but not UCP1. Acute noradrenaline‐induced hyperthermia requires UCP1 but not
Riley, Christopher L., Dao, Christine, Kenaston, M. Alexander, Muto, Luigina, Kohno, Shohei, Nowinski, Sara M., Solmonson, Ashley D., Pfeiffer, Matthew, Sack, Michael N., Lu, Zhongping, FIERMONTE, Giuseppe, Sprague, Jon E., Mills, Edward M.   +12 more
openaire   +3 more sources

Myoglobin‐mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans

Clinical and Translational Medicine, 2022
Background Recruitment and activation of brown adipose tissue (BAT) results in increased energy expenditure (EE) via thermogenesis and represents an intriguing therapeutic approach to combat obesity and treat associated diseases.
Lisa Christen, Helen Broghammer, Inka Rapöhn, Kevin Möhlis, Christian Strehlau, Aleix Ribas‐Latre, Claudia Gebhardt, Lisa Roth, Kerstin Krause, Kathrin Landgraf, Antje Körner, Kerstin Rohde‐Zimmermann, Anne Hoffmann, Nora Klöting, Adhideb Ghosh, Wenfei Sun, Hua Dong, Christian Wolfrum, Tienush Rassaf, Ulrike B. Hendgen‐Cotta, Michael Stumvoll, Matthias Blüher, John T. Heiker, Juliane Weiner   +23 more
doaj   +1 more source

Mutations in valosin-containing protein (VCP) decrease ADP/ATP translocation across the mitochondrial membrane and impair energy metabolism in human neurons [PDF]

, 2017
Mutations in the gene encoding valosin-containing protein (VCP) lead to multisystem proteinopathies including frontotemporal dementia. We have previously shown that patient-derived VCP mutant fibroblasts exhibit lower mitochondrial membrane potential ...
Abramov, Andrey Y. Abramov, Angelova, Bartolome, Bobba, Brand, Brown, Charles Arber, Ding, Edri, Elisavet Preza, Eva Carro, Fernando Bartolome, Ganote, Henry Houlden, Imamura, Johnson, Kokoszka, Krauss, Ludtmann, Macarena de Vicente, Marthe H.R. Ludtmann, Meyer, Muqit, Nalbandian, Nalbandian, Nalbandian, Okita, Papkovskaia, Plun-Favreau, Schirris, Selina Wray, Shi, Shi, Sonia Gandhi, Sposito, Vallier, Vieira, Weihl, Weinbach, Weydt, Wray, Yin, Zhivotovsky   +43 more
core   +2 more sources

Dopamine-stimulated dephosphorylation of connexin 36 mediates AII amacrine cell uncoupling. [PDF]

, 2009
Gap junction proteins form the substrate for electrical coupling between neurons. These electrical synapses are widespread in the CNS and serve a variety of important functions.
Kothmann, W Wade, Massey, Stephen C, O\u27Brien, John   +2 more
core   +1 more source

Uncoupling Protein 2 Increases Blood Pressure in DJ‐1 Knockout Mice

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The redox‐sensitive chaperone DJ‐1 and uncoupling protein 2 are protective against mitochondrial oxidative stress. We previously reported that renal‐selective depletion and germline deletion of DJ‐1 increases blood pressure in mice. This study
Carmen De Miguel, William C. Hamrick, Randee Sedaka, Sudha Jagarlamudi, Laureano D. Asico, Pedro A. Jose, Santiago Cuevas   +6 more
doaj   +1 more source

Phosphorus Supplementation Mitigates Perivascular Adipose Inflammation–Induced Cardiovascular Consequences in Early Metabolic Impairment

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background The complexity of the interaction between metabolic dysfunction and cardiovascular complications has long been recognized to extend beyond simple perturbations of blood glucose levels.
Haneen S. Dwaib, Ghina Ajouz, Ibrahim AlZaim, Rim Rafeh, Ali Mroueh, Nahed Mougharbil, Marie‐Elizabeth Ragi, Marwan Refaat, Omar Obeid, Ahmed F. El‐Yazbi   +9 more
doaj   +1 more source

Mitochondrial proton leak and the uncoupling protein 1 homologues

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2001
Mitochondrial proton leak is the largest single contributor to the standard metabolic rate (SMR) of a rat, accounting for about 20% of SMR. Yet the mechanisms by which proton leak occurs are incompletely understood. The available evidence suggests that both phospholipids and proteins in the mitochondrial inner membrane are important determinants of ...
Mika B. Jekabsons, Damien Roussel, Martin D. Brand, Susana Cadenas, Jeffrey A. Stuart   +4 more
openaire   +2 more sources

Fatty Acids Change the Conformation of Uncoupling Protein 1 (UCP1) [PDF]

Journal of Biological Chemistry, 2012
UCP1 catalyzes proton leak across the mitochondrial inner membrane to disengage substrate oxidation from ATP production. It is well established that UCP1 is activated by fatty acids and inhibited by purine nucleotides, but precisely how this regulation occurs remains unsettled.
Martin D. Brand, Martin D. Brand, Dickon M. Humphrey, Ajit S. Divakaruni, Ajit S. Divakaruni   +4 more
openaire   +2 more sources

Identification of serine phosphorylation in mitochondrial uncoupling protein 1

Biochimica et Biophysica Acta (BBA) - Bioenergetics, 2008
Native uncoupling protein 1 was purified from rat brown adipose tissue of cold-acclimated rats and rats kept at room temperature, in the presence of phosphatase inhibitors. The purified protein from cold-acclimated animals was digested with trypsin and immobilized metal affinity chromatography was used to select for phosphopeptides.
A.M. Carroll, Richard K. Porter, Nick A. Morrice   +2 more
openaire   +3 more sources