Results 51 to 60 of about 127,036 (330)

Electrophysiological Characterization of Mitochondrial Uncoupling Protein 1

Biophysical Journal, 2009
Uncoupling proteins (UCP1- UCP5) are integral transport proteins of the inner mitochondrial membrane (IMM). They mediate transmembrane ion leak, thus dissipating the electrochemical proton gradient across the IMM and uncoupling mitochondrial respiration and ATP synthesis.
Fedorenko, Andriy, Lishko, Polina, Kirichok, Yuriy   +2 more
openaire   +1 more source

MicroRNA-133a-1 regulates inflammasome activation through uncoupling protein-2 [PDF]

Biochemical and Biophysical Research Communications, 2013
Inflammasomes are multimeric protein complexes involved in the processing of IL-1β through Caspase-1 cleavage. NLRP3 is the most widely studied inflammasome, which has been shown to respond to a large number of both endogenous and exogenous stimuli. Although studies have begun to define basic pathways for the activation of inflammasome and have been ...
Sayantani, Bandyopadhyay, Troy, Lane, Rajanbabu, Venugopal, Prasanna Tamarapu, Parthasarathy, Young, Cho, Lakshmi, Galam, Richard, Lockey, Narasaiah, Kolliputi   +7 more
openaire   +2 more sources

Myoglobin‐mediated lipid shuttling increases adrenergic activation of brown and white adipocyte metabolism and is as a marker of thermogenic adipocytes in humans

Clinical and Translational Medicine, 2022
Background Recruitment and activation of brown adipose tissue (BAT) results in increased energy expenditure (EE) via thermogenesis and represents an intriguing therapeutic approach to combat obesity and treat associated diseases.
Lisa Christen, Helen Broghammer, Inka Rapöhn, Kevin Möhlis, Christian Strehlau, Aleix Ribas‐Latre, Claudia Gebhardt, Lisa Roth, Kerstin Krause, Kathrin Landgraf, Antje Körner, Kerstin Rohde‐Zimmermann, Anne Hoffmann, Nora Klöting, Adhideb Ghosh, Wenfei Sun, Hua Dong, Christian Wolfrum, Tienush Rassaf, Ulrike B. Hendgen‐Cotta, Michael Stumvoll, Matthias Blüher, John T. Heiker, Juliane Weiner   +23 more
doaj   +1 more source

Coordinated balancing of muscle oxidative metabolism through PGC-1α increases metabolic flexibility and preserves insulin sensitivity [PDF]

, 2011
The peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α) enhances oxidative metabolism in skeletal muscle. Excessive lipid oxidation and electron transport chain activity can, however, lead to the accumulation of harmful metabolites and ...
Handschin, C., Santos, G., Summermatter, S., Troxler, H.   +3 more
core   +1 more source

Test systems to study the structure and function of uncoupling protein 1: a critical overview

Frontiers in Endocrinology, 2011
The discovery of active brown adipose tissue (BAT) in healthy adult humans has renewed interest in the biology of this organ. BAT is capable of distributing nutrient energy in the form of heat allowing small mammals to efficiently defend their body ...
Verena eHirschberg, Tobias eFromme, Martin eKlingenspor   +2 more
doaj   +1 more source

The Therapeutic Potential of Brown Adipocytes in Humans

Frontiers in Endocrinology, 2015
Obesity and its metabolic consequences represent a significant clinical problem. From a thermodynamic standpoint, obesity results from a discord in energy intake and expenditure.
Craig ePorter, Craig ePorter, Maria eChondronikola, Maria eChondronikola, Labros S Sidossis, Labros S Sidossis, Labros S Sidossis   +6 more
doaj   +1 more source

Role of gut microbiota in the postnatal thermoregulation of Brandt’s voles

Cell Reports, 2023
Summary: Homeothermy is crucial for mammals. Postnatal growth is the key period for young offspring to acquire gut microbiota. Although gut microbiota may affect mammal thermogenesis, the impact of developmental regulation of gut microbiota on the ...
Tingbei Bo, Liqiu Tang, Xiaoming Xu, Min Liu, Jing Wen, Jinzhen Lv, Dehua Wang   +6 more
doaj   +1 more source

Fatty Acids Change the Conformation of Uncoupling Protein 1 (UCP1) [PDF]

Journal of Biological Chemistry, 2012
UCP1 catalyzes proton leak across the mitochondrial inner membrane to disengage substrate oxidation from ATP production. It is well established that UCP1 is activated by fatty acids and inhibited by purine nucleotides, but precisely how this regulation occurs remains unsettled.
Ajit S, Divakaruni, Dickon M, Humphrey, Martin D, Brand   +2 more
openaire   +2 more sources

Brown adipose tissue in adult humans: A mini review

Journal of Clinical and Scientific Research, 2019
Adipose tissue is of two types: white adipose tissue (WAT) and brown adipose tissue (BAT). For a long time, it was considered that BAT is present only in hibernating animals and newborns, conferring them a protection from the cold environment.
V S Kiranmayi, K M Bhargav
doaj   +1 more source

Perilipin regulates the thermogenic actions of norepinephrine in brown adipose tissue [PDF]

, 2007
In response to cold, norepinephrine (NE)-induced triacylglycerol hydrolysis (lipolysis) in adipocytes of brown adipose tissue (BAT) provides fatty acid substrates to mitochondria for heat generation (adaptive thermogenesis).
Bianco, Antonio C., Christoffolete, Marcelo A., D'Eon, Tara M., Greenberg, Andrew S., Imachi, Hitomi, Miyoshi, Hideaki, Obin, Martin S., Perfield, James W., II, Ribeiro, Miriam O., Rogers, Nicole H., Souza, Sandra C., Stancheva, Zlatina S., Strissel, Katherine J.   +12 more
core   +1 more source