Brown fat in obesity: Uncoupling protein-1 versus thermogenic activity. [PDF]
Temperature (Austin), 2017 Madden CJ.
europepmc +5 more sources
Brown adipose tissue in adult humans: A mini review
Journal of Clinical and Scientific Research, 2019 Adipose tissue is of two types: white adipose tissue (WAT) and brown adipose tissue (BAT). For a long time, it was considered that BAT is present only in hibernating animals and newborns, conferring them a protection from the cold environment.
V S Kiranmayi, K M Bhargav
doaj +1 more source
Programming mediated by fatty acids affects uncoupling protein 1 (UCP-1) in brown adipose tissue
British Journal of Nutrition, 2018 Brown adipose tissue (BAT) has recently been given more attention for the part it plays in obesity. BAT can generate great amounts of heat through thermogenesis by the activation of uncoupling protein 1 (UCP-1), which can be regulated by many ...
P. P. Argentato +3 more
semanticscholar +1 more source
Synergistic interaction of fatty acids and oxysterols impairs mitochondrial function and limits liver adaptation during nafld progression [PDF]
, 2018 The complete mechanism accounting for the progression from simple steatosis to steatohepatitis in nonalcoholic fatty liver disease (NAFLD) has not been elucidated.
Avolio, Carlo +11 more
core +2 more sources
Purine Nucleotides Similarly Regulate Uncoupling Protein 3 and 1 [PDF]
Biophysical Journal, 2014 ATP generation is fueled by an electrical potential across the inner mitochondrial membrane (IMM), which can be decreased by an uncoupling protein (UCP) facilitated proton leak. Apart from UCP1, which supports non-shivering thermogenesis, the function of the other UCPs, such as UCP3, remains unknown.
Elena E. Pohl +4 more
openaire +2 more sources
Novel insights into pancreatic β-cell glucolipotoxicity from real-time functional analysis of mitochondrial energy metabolism in INS-1E insulinoma cells. [PDF]
, 2013 Work in our lab is supported by the Medical Research Council [New Investigator Research Grant G1100165 to CA] and Plymouth University [PhD studentship to JB] The final version of record is available at http://www.biochemj.org/bj/456/bj4560417.htmHigh ...
Affourtit, C, Barlow, J
core +2 more sources
The Therapeutic Potential of Brown Adipocytes in Humans
Frontiers in Endocrinology, 2015 Obesity and its metabolic consequences represent a significant clinical problem. From a thermodynamic standpoint, obesity results from a discord in energy intake and expenditure.
Craig ePorter +6 more
doaj +1 more source
mTORC2 sustains thermogenesis via Akt-induced glucose uptake and glycolysis in brown adipose tissue [PDF]
, 2016 Activation of non-shivering thermogenesis (NST) in brown adipose tissue (BAT) has been proposed as an anti-obesity treatment. Moreover, cold-induced glucose uptake could normalize blood glucose levels in insulin-resistant patients.
Albert V +12 more
core +4 more sources
Possible involvement of uncoupling protein 1 in appetite control by leptin [PDF]
Experimental Biology and Medicine, 2011 Leptin reduces body fat by decreasing food intake and increasing energy expenditure. Uncoupling protein (UCP) 1, a key molecule for brown adipose tissue (BAT) thermogenesis, was reported to contribute to the stimulatory effect of leptin on energy expenditure.
Akira Terao +6 more
openaire +4 more sources