Results 1 to 10 of about 22,011 (155)

Gelsolin induces colorectal tumor cell invasion via modulation of the urokinase-type plasminogen activator cascade [PDF]

, 2012
Gelsolin is a cytoskeletal protein which participates in actin filament dynamics and promotes cell motility and plasticity. Although initially regarded as a tumor suppressor, gelsolin expression in certain tumors correlates with poor prognosis and ...
Alan Prem Kumar, Antonio Moschetta, Benedict Yan, Celestial T. Yap, Ee Hong Tan, Hwee Kee Tay, Jingli Zhuo, Lalchhandami Tochhawng, Manikandan Jayapal, Manuel Salto-Tellez, Shing Chuan Hooi, Shiuan Koh, Sutherland K. Maciver, Yaw Chong Goh, Yaw Chyn Lim   +14 more
core   +10 more sources

Overexpression of the urokinase receptor splice variant uPAR-del4/5 in breast cancer cells affects cell adhesion and invasion in a dose-dependent manner and modulates transcription of tumor-associated genes [PDF]

, 2012
mRNA levels of the urokinase receptor splice variant uPAR-del4/5 are associated with prognosis in breast cancer. Its overexpression in cancer cells affects tumor biologically relevant processes.
Baretton, Gustavo, Grismayer, Bettina, Kopitz, Charlotte, Kotzsch, Matthias, Krueger, Achim, Luther, Thomas, Magdolen, Viktor, Ries, Christian, Sato, Sumito, Schmitt, Manfred, Soelch, Susanne   +10 more
core   +1 more source

Cyclo19,31[D-Cys19]-uPA19-31 is a potent competitive antagonist of the interaction of urokinase-type plasminogen activator with its receptor (CD87) [PDF]

, 2001
Urokinase-type plasminogen activator (uPA) represents a central molecule in pericellular proteolysis and is implicated in a variety of physiological and pathophysiological processes such as tissue remodelling, wound healing, tumor invasion, and ...
Arroyo de Prada, Nuria, Bürgle, Markus, Degitz, Klaus, Kellermann, Josef, Kessler, Horst, Magdolen, Viktor, Riemer, Christoph, Schmiedeberg, Niko, Schmitt, Manfred, Schroeck, Florian, Wilhelm, Olaf G.   +10 more
core   +1 more source

Negative regulation of urokinase receptor activity by a GPI-specific phospholipase C in breast cancer cells. [PDF]

, 2017
The urokinase receptor (uPAR) is a glycosylphosphatidylinositol (GPI)-anchored protein that promotes tissue remodeling, tumor cell adhesion, migration and invasion.
De Lorenzi, Valentina, Jalink, Kees, Kedziora, Katarzyna M., Leyton-Puig, Daniela, Matas-Rico, Elisa, Moolenaar, Wouter H., Perrakis, Anastassis, Sidenius, Nicolai, Stijf-Bultsma, Yvette, van de Wetering, Koen, van den Broek, Bram, van Veen, Michiel   +11 more
core   +3 more sources

HGF modulates actin cytoskeleton remodeling and contraction in testicular myoid cells [PDF]

, 2015
The presence of the HGF/Met system in the testicular myoid cells was first discovered by our group. However, the physiological role of this pathway remains poorly understood. We previously reported that HGF increases uPA secretion and TGF-β activation in
Angela, Catizone, Caruso, Maria, Galdieri, Michela, Ricci, Giulia, Rita, Canipari, Scheri, Katia Corano, Virginia, Di Paolo   +6 more
core   +1 more source

Pericellular activation of hepatocyte growth factor by the transmembrane serine proteases matriptase and hepsin, but not by the membrane-associated protease uPA [PDF]

, 2009
HGF (hepatocyte growth factor) is a pleiotropic cytokine homologous to the serine protease zymogen plasminogen that requires canonical proteolytic cleavage to gain functional activity.
Andrew M. Schumacher, Birchmeier, Bugge, Chirgadze, Collen, Deyi Qiu, Ellis, Ellis, Gherardi, Harris, Herter, Høyer-Hansen, Itoh, Jennifer L. Harris, Juliano Alves, Jun Li, Kate A. Owen, Ke, Kemp, Kilpatrick, Kirchhofer, Kirchhofer, Lamszus, Lee, Lynette M. Kilpatrick, Mangel, Marcotte, Mars, Mars, Matsuoka, Miyazawa, Mizuno, Mohammed, Naldini, Naldini, Qiu, Rahman, Riddick, Schmidt, Shanmukhappa, Shimizu, Shimomura, Steinmetzer, Stephens, Takeuchi, Uehara, Vincent Ellis, You   +47 more
core   +3 more sources

Airway and peripheral urokinase plasminogen activator receptor is elevated in asthma, and identifies a severe, nonatopic subset of patients [PDF]

, 2016
Rationale: Genetic polymorphisms in the asthma susceptibility gene, urokinase plasminogen activator receptor (uPAR/PLAUR) have been associated with lung function decline and uPAR blood levels in asthma subjects.
Barton, Chu, Chung, Gilder, Haldar, Howarth, Huang, Humbert, Jo, Koppelman, Lotvall, Maas, Merrett, Moore, O'Byrne, O'Byrne P, Plesner, Ploug, Ploug, Portelli, Portelli, Rackemann, Rochat, Shaw, Siroux, Stewart, Stewart, Thuno, Wan, Wang, Wang, Wei, Westra, Willart, Xiao   +34 more
core   +9 more sources

Fluctuating Nonlinear Spring Model of Mechanical Deformation of Biological Particles [PDF]

, 2015
We present a new theory for modeling forced indentation spectral lineshapes of biological particles, which considers non-linear Hertzian deformation due to an indenter-particle physical contact and bending deformations of curved beams modeling the ...
Gijs J L Wuite, Joost Snijder, Kenneth A Marx, Olga Kononova, Valeri Barsegov, Wouter H Roos, Yaroslav Kholodov   +6 more
core   +4 more sources

Roles and regulation of membrane-associated serine proteases [PDF]

, 2007
Pericellular proteolytic activity affects many aspects of cellular behaviour, via mechanisms involving processing of the extracellular matrix, growth factors and receptors.
Bass, Rosemary, Ellis, V, Gray, Kelly, Owen, K, Qiu, Deyi   +4 more
core   +1 more source

Soluble gC1qR is an autocrine signal that induces B1R expression on endothelial cells [PDF]

, 2013
Bradykinin (BK) is one of the most potent vasodilator agonists known and belongs to the kinin family of proinflammatory peptides. BK induces its activity via two G protein-coupled receptors: BK receptor 1 (B1R) and BK receptor 2.
David, H, Galanakis, DK, Ghebrehiwet, B, Hosszu, KH, Ji, Y, Kew, RR, Kishore, U, Pednekar, L, Peerschke, EIB, Ramadass, M, Valentino, A   +10 more
core   +2 more sources