Results 11 to 20 of about 22,011 (155)
RhoB regulates uPAR signalling [PDF]
Journal of Cell Science, 2012 uPA and its receptor, uPAR, play important roles in promoting cancer cell adhesion, migration and invasion. Rho GTPases are key coordinators of these processes; the Rho GTPase Rac1 has previously been implicated in uPA/uPAR-induced migratory or morphological cell responses.
Daniela Alfano +3 more
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Cell Adhesion & Migration, 2013 Vascular endothelial growth factor (VEGF)-initiated angiogenesis requires both coordinated proteolytic degradation of extracellular matrix provided by the urokinase plasminogen activator/urokinase receptor (uPA/uPAR) system and regulation of cell-migration provided by integrin-matrix interaction.
Pavel, Uhrin, Johannes M, Breuss
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uPAR: An Essential Factor for Tumor Development [PDF]
Journal of Cancer, 2021 Tumorigenesis is closely related to the loss of control of many genes. Urokinase-type plasminogen activator receptor (uPAR), a glycolipid-anchored protein on the cell surface, is controlled by many factors in tumorigenesis and is expressed in many tumor tissues.
Lv, Tao +8 more
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uPAR mediates anticancer activity of PEDF [PDF]
Cancer Biology & Therapy, 2008 Osteosarcoma (OS) is a cancer which afflicts the bone, ending in usually fatal lung metastasis mainly in teenagers and adolescents. We have recently shown that PEDF is one biological that has multiple anti-OS activity. In parallel, we have also shown using rodent cells, the beneficial effects of downregulation of uPAR against OS.
Dass, Crispin R, Choong, Peter F. M
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uPAR as a Glioma Imaging Target [PDF]
Journal of Nuclear Medicine, 2015 Gliomas account for 70% of primary brain tumors ([1][1]). Among the various types of glioma, glioblastoma is the most aggressive astrocytic tumor, being classified grade IV by the World Health Organization ([2][2]). Although CT and MRI are indispensable in providing morphologic information,
Kenji, Hirata, Nagara, Tamaki
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Efferocytosis: another function of uPAR
Blood, 2009 uPAR, the receptor for urokinase plasminogen activator, is a regulator of the uptake by macrophages of apoptotic neutrophils (efferocytosis). Its role and mechanism appear to be complex and possibly controversial.
Blasi, Francesco, Sidenius, Nicolai
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Generation of Antibodies to the Urokinase Receptor (uPAR) by DNA Immunization of uPAR Knockout Mice: Membrane‐Bound uPAR is Not Required for an Antibody Response [PDF]
Scandinavian Journal of Immunology, 2003 AbstractThe urokinase receptor (uPAR) is a glycolipid‐anchored cell surface glycoprotein that plays a central role in extracellular proteolysis during tissue remodeling processes including cancer invasion. Furthermore, uPAR is found on the surface of both dendritic cells (DCs) and T cells, and has been proposed to play a role in DC‐induced T‐cell ...
J, Pass +4 more
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Domain 1 of the urokinase receptor (uPAR) is required for uPAR‐mediated cell binding to vitronectin [PDF]
FEBS Letters, 2000 In the present paper we have analyzed uPAR‐mediated cellular binding to vitronectin using the murine erythroid progenitor cell line 32D. We show that expression of uPAR in 32D cells promotes cellular binding to vitronectin, but fails to support cell spreading.
Sidenius, Nicolai, Blasi, Francesco
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uPAR's signaling two step [PDF]
The Journal of Cell Biology, 2007 The uPA receptor (uPAR) is a loner. Jutting from the plasma membrane, it has no apparent connection to the cell interior. But, as Madsen et al. demonstrate on page 927, uPAR induces cells to cling tightly to a surface. The behavior might recruit other receptors and explain how the seemingly isolated uPAR exerts its influence.
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Antagonistic Anti-urokinase Plasminogen Activator Receptor (uPAR) Antibodies Significantly Inhibit uPAR-mediated Cellular Signaling and Migration [PDF]
Journal of Biological Chemistry, 2010 Interactions between urokinase plasminogen activator receptor (uPAR) and its various ligands regulate tumor growth, invasion, and metastasis. Antibodies that bind specific uPAR epitopes may disrupt these interactions, thereby inhibiting these processes.
Sai, Duriseti +5 more
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