Results 21 to 30 of about 22,011 (155)
Crystal structure and cellular functions of uPAR dimer
Nature Communications, 2022 Abstract Receptor dimerization of urokinase-type plasminogen activator receptor (uPAR) was previously identified at protein level and on cell surface. Recently, a dimeric form of mouse uPAR isoform 2 was proposed to induce kidney disease. Here, we report the crystal structure of human uPAR dimer at 2.96 Å.
Shujuan Yu +9 more
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, 2009 Das uPA (Urokinase)-/ uPAR (Urokinaserezeptor)- System ist primär als Fibrinolysesystem bekannt, stellt jedoch zusätzlich ein multifunktionelles System mit einem breitem Einflussspektrum auf inflammatorische Prozesse, Gefäßerkrankungen und Karzinomleiden dar.
Petzinger, Jutta +1 more
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Novel bi- and trifunctional inhibitors of tumor-associated proteolytic systems [PDF]
, 2003 Serine proteases, cysteine proteases, and matrix metalloproteinases (MMPs) are involved in cancer cell invasion and metastasis. Recently, a recombinant bifunctional inhibitor (chCysuPA(19-31)) directed against cysteine proteases and the urokinasetype ...
Brew K. +11 more
core +2 more sources
Orientational Preferences of GPI-Anchored Ly6/uPAR Proteins
International Journal of Molecular Sciences, 2022 Ly6/uPAR proteins regulate many essential functions in the nervous and immune systems and epithelium. Most of these proteins contain single β-structural LU domains with three protruding loops and are glycosylphosphatidylinositol (GPI)-anchored to a membrane. The GPI-anchor role is currently poorly studied.
Maxim M. Zaigraev +4 more
openaire +2 more sources
The FASEB Journal, 2018 Human CYP1B1 is known as a major metabolizer for estrogen and shows tumor‐specific hyper‐expression. To explore the role of CYP1B1 on metastasis of human cancer cells, we studied the effects of CYP1B1 inhibition and activation in MCF‐10A, MCF‐7, MDA‐MB‐231, and HeLa cells.
Yeo‐Jung Kwon +3 more
openaire +1 more source
Early increases in plasminogen activator activity following partial hepatectomy in humans [PDF]
, 2004 Background Increases in urokinase-like plasminogen activator (uPA) activity are reported to be amongst the earliest events occurring in remnant liver following partial hepatectomy in rats, and have been proposed as a key component of the regenerative ...
Bird, N.C. +3 more
core +2 more sources
Protease inhibitors prevent plasminogen-mediated, but not pemphigus vulgaris-induced, acantholysis in human epidermis [PDF]
, 2003 Pemphigus is an autoimmune blistering disease of the skin and mucous membranes. It is caused by autoantibodies directed against desmosomes, which are the principal adhesion structures between epidermal keratinocytes.
Besch, R. +9 more
core +1 more source
PLoS ONE, 2011 Meningiomas are the most commonly occurring intracranial tumors and account for approximately 15-20% of central nervous system tumors. Surgery and radiation therapy is a common treatment for brain tumors, however, patients whose tumors recur after such treatments have limited therapeutic options.
Reshu Gupta +8 more
openaire +7 more sources
Hydroxytyrosol targets extracellular matrix remodeling by endothelial cells and inhibits both ex vivo and in vivo angiogenesis [PDF]
, 2016 This is the preprint version of our manuscript, corresponding to the article that has been published in final form at FOOD CHEMISTRY with DOI: 10.1016/j.foodchem.2016.10.111The health benefits of olive oil are attributed to their bioactive compounds ...
García-Vilas, Javier A. +2 more
core +1 more source
Nephrology Dialysis Transplantation, 2020 Abstract Background and Aims The role of suPAR as a biomarker and/or causative factor in the pathogenesis of recurrent FSGS remains unclear (Harel E., et al. Transplantation 2020; 104:54-60). While anti-suPAR antibodies have been shown to block suPAR induced podocyte injury in mouse models of FSGS ...
Minnie Sarwal +5 more
openaire +1 more source