Results 51 to 60 of about 22,011 (155)
Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma
The FEBS Journal, EarlyView.Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris +2 more
wiley +1 more source
Cytotoxicity of the urokinase-plasminogen activator inhibitor carbamimidothioic acid (4-boronophenyl) methyl ester hydrobromide (BC-11) on triple-negative MDA-MB231 breast cancer cells [PDF]
, 2015 : BC-11 is an easily synthesized simple thiouronium-substituted phenylboronic acid, which has been shown to be cytotoxic on triple negative MDA-MB231 breast cancer cells by inducing a perturbation of cell cycle when administered at a concentration equal ...
Baltus, Christine B +5 more
core +2 more sources
International Journal of Dental Hygiene, EarlyView.ABSTRACT Introduction The plasminogen activating (PA) system has a multitude of functions such as wound healing, proteolytic activity, collagen degradation and cell growth, and the role of the urokinase plasminogen activator/urokinase plasminogen activator receptor (uPA/uPAR) system has been studied in many disease states.
Ahmed Khudhur +6 more
wiley +1 more source
First results of the OROMA experiment in the Lister Tief of the German Bight in the North Sea, EARSeL Proceedings [PDF]
, 2004 The objective of the project entitled “Operational Radar and Optical Mapping in monitoring hydrodynamic, morphodynamic and environmental parameters for coastal management (OROMA)” within the Fifth Framework Programme of the European Commission (EC) is ...
Hennings, Ingo +3 more
core
Functional characterization of αMβ2-uPar interaction [PDF]
, 2019 The cell adhesion molecule integrin αMβ2, one of the β2 integrins, associates with the urokinase-type plasminogen activator receptor (uPAR) on monocytes and neutrophils. The GPI-linked uPAR also associates with members of the βl and β3 integrins, and it modulates the ligand-binding and migration functions of these integrins.
openaire +3 more sources
Melatonin and the Dental Pulp: A Scoping Review
International Endodontic Journal, EarlyView.ABSTRACT Background In general medicine, melatonin is known to enhance wound healing and promote stem cell differentiation. Its potential relevance in endodontics, however, remains underexplored. Objectives This scoping review aimed to systematically assess the available evidence on the effects of melatonin (a) on dental pulp tissue and (b) on human ...
Jasmin Schäfer +2 more
wiley +1 more source
MMP-9 and uPAR regulated glioma cell migration [PDF]
Cell Adhesion & Migration, 2012 Integrin-dependent and -independent MMP-9 and uPAR signaling plays a key role in glioma cell migration and invasion. In this article, we comment on all the possible pathways and molecules associated with MMP-9- and uPAR-mediated glioma cell migration with a special emphasis on integrins, a family of cell adhesion molecules.
Veeravalli, Krishna Kumar, Rao, Jasti S.
openaire +2 more sources
Minimal Evidence of Inflammaging in Naturalistic Chimpanzee Populations
American Journal of Biological Anthropology, Volume 189, Issue 2, February 2026.ABSTRACT Objectives Whereas chronic inflammation is a hallmark of aging in many human populations, inflammaging is reduced in groups characterized by frequent physical activity and diets low in processed foods. Since most biomarkers of inflammation require blood sampling, comparative data from our closest primate relatives have been derived from ...
Megan F. Cole +6 more
wiley +1 more source
Distinct ligand binding sites in integrin alpha3beta1 regulate matrix adhesion and cell-cell contact. [PDF]
, 2003 The integrin alpha3beta1 mediates cellular adhesion to the matrix ligand laminin-5. A second integrin ligand, the urokinase receptor (uPAR), associates with alpha3beta1 via a surface loop within the alpha3 beta-propeller (residues 242-246) but outside ...
Chapman, Harold A +6 more
core
, 2008 We calculate the Casimir interaction between parallel planar crystals of Au and the anisotropic cuprate superconductor Bi2Sr2CaCu2O8+delta (BSCCO), with BSCCO's optical axis either parallel or perpendicular to the crystal surface, using suitable ...
E. M. Lifshitz +5 more
core +1 more source