Results 71 to 80 of about 22,011 (155)

Treatment with a Urokinase Receptor-derived Cyclized Peptide Improves Experimental Colitis by Preventing Monocyte Recruitment and Macrophage Polarization [PDF]

, 2016
Leukocyte migration across the blood barrier and into tissues represents a key process in the pathogenesis of inflammatory bowel diseases. The urokinase receptor (urokinase-type plasminogen activator receptor) is a master regulator of leukocyte ...
Carriero, Maria V, Danese, Silvio, Fonteyne, Philippe, Genua, Marco, GRIECO, PAOLO, Ingangi, Vincenzo, Malesci, Alberto, MERLINO, FRANCESCO, Piontini, Andrea, YOUSIF, ALI MUNAIM   +9 more
core   +1 more source

Differential Roles of uPAR in Peritoneal Ovarian Carcinomatosis

Neoplasia, 2012
Epithelial ovarian cancer is the fourth leading cause of death from gynecologic malignancies in the United States. Most cases are diagnosed at late stages, with the solid tumor masses growing as peritoneal implants, or floating within the ascitic fluid (peritoneal ovarian carcinomatosis).
Nada N. Al-Hassan, Ali Behzadian, Ruth Caldwell, Vessela S. Ivanova, Viqar Syed, Kouros Motamed, Neveen A. Said   +6 more
openaire   +3 more sources

Exploring the Fecal Microbiome Dysbiosis and Its Plasma Metabolome Determinants in Advanced Parkinson's Disease With Motor Complications

CNS Neuroscience &Therapeutics, Volume 32, Issue 1, January 2026.
Our multiomics analysis across three PD cohorts revealed distinct fecal microbiome and plasma metabolome alterations in patients with motor complications (PD‐MC). We identified specific microbial and metabolic biomarkers and uncovered significant correlations between them, providing new insights into PD‐MC pathophysiology. ABSTRACT Background Parkinson'
Shuangjie Qian, Jialong Hou, Xi Xiong, Qi Duan, Tao Jiang, Yi Zheng, Weiwei Quan, Jiaxue Xu, Keke Chen, Jingjing Qian, Hongchang Gao, Chenglong Xie   +11 more
wiley   +1 more source

Selection of optimal molecular targets for tumor-specific imaging in pancreatic ductal adenocarcinoma [PDF]

, 2017
Discrimination of pancreatic ductal adenocarcinoma (PDAC) from chronic pancreatitis (CP) or peritumoral inflammation is challenging, both at preoperative imaging and during surgery, but it is crucial for proper therapy selection. Tumor-specific molecular
Bonsing, B.A. (Bert), Boonstra, M.C. (M.), Eijck, C.H.J. (Casper) van, Fariña-Sarasqueta, A. (Arantza), Kuppen, P.J.K. (P. J K), Mieog, J.S.D. (Sven), Morreau, H. (Hans), Prevoo, H.A. (Hendrica A.), Sier, C.F.M. (Cornelis), Swijnenburg, R.-J. (Rutger-Jan), Tummers, W.S. (Willemieke S.), Vahrmeijer, A.L. (Alexander L.), Velde, C.J.H. (Cornelis) van de   +12 more
core   +1 more source

Emerging Therapeutic Strategies in Anti‐Aging Medicine: A Comprehensive Review

Medicine Bulletin, Volume 2, Issue 1, Page 94-123, January 2026.
ABSTRACT Aging is orchestrated by interconnected hallmarks such as genomic instability, mitochondrial dysfunction, cellular senescence, and disrupted intercellular communication, which collectively drive chronic disease progression. Recent advances have expanded therapeutic opportunities to include pharmacological agents, gene and epigenome editing ...
Yundong Peng, Rui Li, Huan Li, Jun Zhou, Xuanshi Liu, Guilherme Valente, Tatiana de Campos Melo, Sifan Chen, Lei Gu   +8 more
wiley   +1 more source

The uPA/uPAR system in astrocytic wound healing

Neural Regeneration Research, 2022
The repair of injured tissue is a highly complex process that involves cell proliferation, differentiation, and migration. Cell migration requires the dismantling of intercellular contacts in the injured zone and their subsequent reconstitution in the wounded area. Urokinase-type plasminogen activator (uPA) is a serine proteinase found in multiple cell
openaire   +3 more sources

Attenuation of urokinase activity during experimental ischaemia protects the cerebral barrier from damage through regulation of matrix metalloproteinase-2 and NAD(P)H oxidase [PDF]

, 2014
Ischaemic injury impairs the integrity of the blood–brain barrier (BBB). In this study, we investigated the molecular causes of this defect with regard to the putative correlations among NAD(P)H oxidase, plasminogen–plasmin system components, and matrix ...
Ahn, Allen, Allen, Allen, Asahi, Asahi, Asahi, Baramova, Barr, Bayraktutan, Brouns, Cavdar, Chen, Chen, Cho, Chrissobolis, Ear, Eltzschig, Fuhrman, Hacke, Haworth, Hayashi, Hayashi, Higazi, Hong, Hosomi, Irigoyen, Kleikers, Kleinschnitz, Liu, Lucivero, Margaill, Nakase, Persidsky, Raat, Rosenberg, Selemidis, Shao, Shuaib, Suofu, Tahanian, Thornton, Tsuji, Walder, Wang, Wang   +45 more
core   +2 more sources

Targeting uPAR in diabetic vascular pathologies*

Postępy Higieny i Medycyny Doświadczalnej, 2019
The uPAR protein is one of the most important elements in fibrinolysis. uPAR is associated with many biological processes, such as cell invasion, angiogenesis and cell proliferation. Because of its multifunctional character, it is difficult to produce an effective inhibitor of uPA-uPAR interactions.
Martyna Durak-Kozica, Francisco J. Enguita, Ewa Stępień   +2 more
openaire   +1 more source

Shedding and cleavage of the urokinase receptor (uPAR): identification and characterisation of uPAR fragments in vitro and in vivo

FEBS Letters, 2000
Applying a novel, highly specific and sensitive immunoabsorption/Western blotting technique we have identified in vitro in conditioned cell culture medium and in vivo in human urine different soluble forms of the urokinase‐type plasminogen activator receptor (uPAR/CD87). These include the uPAR fragment D2D3 and the never before identified domain 1 (D1)
Sidenius, Nicolai, Sier, Cornelis F.M, Blasi, Francesco   +2 more
openaire   +2 more sources

SPRY1 promotes the degradation of uPAR and inhibits uPAR-mediated cell adhesion and proliferation.

American journal of cancer research, 2014
Urokinase plasminogen activator receptor (uPAR) is a GPI anchored cell surface protein that is closely associated with invasion, migration, and metastasis of cancer cells. Many functional extracellular proteins and transmembrane receptors interact with uPAR. However, few studies have examined the association of uPAR with cytoplasm proteins.
Xiufeng, Liu, Yan, Lan, Di, Zhang, Kai, Wang, Yao, Wang, Zi-Chun, Hua   +5 more
openaire   +1 more source