The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl‐leukotrienes receptor [PDF]
The EMBO Journal, 2006 Nucleotides and cysteinyl-leukotrienes (CysLTs) are unrelated signaling molecules inducing multiple effects through separate G-protein-coupled receptors: the P2Y and the CysLT receptors. Here we show that GPR17, a Gi-coupled orphan receptor at intermediate phylogenetic position between P2Y and CysLT receptors, is specifically activated by both families
P. Ciana +17 more
semanticscholar +8 more sources
UdgX-Mediated Uracil Sequencing at Single-Nucleotide Resolution [PDF]
Journal of the American Chemical Society, 2022 As an aberrant base in DNA, uracil is generated by either deoxyuridine (dU) misincorporation or cytosine deamination, and involved in multiple physiological and pathological processes. Genome-wide profiles of uracil are important for study of these processes.
Liudan Jiang +19 more
+6 more sources
Deletion of the Uracil Permease Gene Confers Cross-Resistance to 5-Fluorouracil and Azoles in Candida lusitaniae and Highlights Antagonistic Interaction between Fluorinated Nucleotides and Fluconazole [PDF]
Antimicrobial Agents and Chemotherapy, 2014 F. Gabriel +8 more
semanticscholar +2 more sources
Responses of the longitudinal muscle and the muscularis mucosae of the rat duodenum to adenine and uracil nucleotides [PDF]
British Journal of Pharmacology, 1996 C.R. Johnson, S. Charlton, S. Hourani
semanticscholar +2 more sources
Uracil Nucleotide/Cysteinyl Leukotriene Receptor
, 2020 National Cancer Institute
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The Orphan Receptor GPR17 Is Unresponsive to Uracil Nucleotides and Cysteinyl Leukotrienes [PDF]
Molecular Pharmacology, 2017 Pairing orphan G protein–coupled receptors (GPCRs) with their cognate endogenous ligands is expected to have a major impact on our understanding of GPCR biology. It follows that the reproducibility of orphan receptor ligand pairs should be of fundamental importance to guide meaningful investigations into the pharmacology and function of individual ...
Katharina Simon +12 more
semanticscholar +3 more sources
Nucleotide sequence of theStreptococcus pneumoniae unggene encoding uracil-DNA glycosylase [PDF]
Nucleic Acids Research, 1990 Vincent Méjean +2 more
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The Importance of the Fifth Nucleotide in DNA: Uracil
, 2023 Uracil is a ribonucleotide found in both DNA and RNA, with the main difference between the two being the presence of thymine in DNA and uracil in RNA. Although thymine and uracil are similar in function and can form the same base pairs with adenine, the presence of uracil in DNA can affect DNA stability and modulate cell-specific functions.
Jamie Z. Roberts, Melissa J. LaBonte
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Single-nucleotide patch base excision repair of uracil in DNA by mitochondrial protein extracts# [PDF]
Nucleic Acids Research, 1999 Mammalian mitochondria contain several 16.5 kb circular DNAs (mtDNA) encoding electron transport chain proteins. Reactive oxygen species formed as byproducts from oxidative phosphorylation in these organelles can cause oxidative deamination of cytosine and lead to uracil in mtDNA.
Rob Stierum +2 more
openalex +4 more sources
Involvement of uracil nucleotides in protection of cardiomyocytes from hypoxic stress. [PDF]
Biochemical Pharmacology, 2005 Cardiomyocytes express one or more subtypes of P2 receptors for extracellular nucleotides. P2 purinoceptors, which are activated by nucleotides, are classified as P2X or P2Y: P2X receptors are ligand-gated intrinsic ion channels, and P2Y receptors are G protein-coupled receptors.
Smadar Yitzhaki +3 more
semanticscholar +3 more sources