Diverse Phytochemicals and Bioactivities in the Ancient Fruit and Modern Functional Food Pomegranate (Punica granatum) [PDF]
Molecules, 2017 Having served as a symbolic fruit since ancient times, pomegranate (Punica granatum) has also gained considerable recognition as a functional food in the modern era. A large body of literature has linked pomegranate polyphenols, particularly anthocyanins
Sheng Wu, Li Tian
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The presence and induction of regioselective dehydroxylases dictate urolithin metabolism by Enterocloster species [PDF]
npj Biofilms and MicrobiomesUrolithins are a class of bioactive metabolites derived from the metabolism of dietary ellagitannins by the human gut microbiota. In the gut, urolithins are dehydroxylated regioselectively based on microbiota composition and activity.
Reilly Pidgeon +3 more
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Urolithin A Protects Ovarian Reserve Via Inhibiting PI3K/Akt Signaling and Preventing Chemotherapy-Induced Follicle Apoptosis [PDF]
BiologyUrolithin A, which is a natural gut microbial metabolite, exerts multiple beneficial effects upon supplementation, including prolonging lifespan, mitigating diseases, restoring the quality of aged oocytes and alleviating drug toxicity.
Weiyong Wang +3 more
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The Punicalagin Metabolites Ellagic Acid and Urolithin A Exert Different Strengthening and Anti-Inflammatory Effects on Tight Junction-Mediated Intestinal Barrier Function In Vitro [PDF]
Frontiers in Pharmacology, 2021 Scope: Ellagitannins are polyphenols found in numerous fruits, nuts and seeds. The elagitannin punicalagin and its bioactive metabolites ellagic acid and urolithins are discussed to comprise a high potential for therapeutically or preventive medical ...
Nina A. Hering +4 more
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Urolithin A increases the natural killer activity of PBMCs in patients with prostate cancer [PDF]
Frontiers in PharmacologyBackgroundThe natural killer (NK) activity of peripheral blood mononuclear cells (PBMCs) is a crucial defense against the onset and spread of cancer.
Vladimir Rogovskii +10 more
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Determination of Urolithin A in Health Products by Ultra-High-Performance Liquid Chromatography [PDF]
MoleculesThis study establishes and validates a novel ultra-high-performance liquid chromatography (UHPLC) method for the determination of urolithin A content in health products, a bioactive compound with potential anti-aging properties.
Yue E, Zhuang Wang, Jiahui Nie
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Microbiota-derived urolithin A in monoclonal gammopathies and multiple myeloma therapy [PDF]
MicrobiomeBackground Gut microbiota-derived urolithins may influence multiple myeloma (MM) disease progression and treatment. We analyzed urolithins and their associated microbiota in a retrospective cohort of 45 patients with active MM or premalignant disease ...
Alba Rodríguez-García +18 more
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Foods, 2022 Urolithin A, a metabolite of ellagic acid, has many beneficial biological activities for people. Strains capable of producing urolithin A from ellagic acid have the hope of becoming the next-generation probiotics.
Qitong Liu +8 more
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Differential Role of Active Compounds in Mitophagy and Related Neurodegenerative Diseases
Toxins, 2023 Neurodegenerative diseases, such as Alzheimer’s disease or Parkinson’s disease, significantly reduce the quality of life of patients and eventually result in complete maladjustment. Disruption of the synapses leads to a deterioration in the communication
Mark Makarov, Eduard Korkotian
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Biochemistry and Biophysics Reports, 2021 Ellagitannins (esters composed of glucose and ellagic acid) are hydrolyzed to generate ellagic acid in gut followed by conversion of ellagic acid to urolithins such as urolithin A by intestinal bacteria.
Hidehiko Kikuchi +3 more
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