Results 91 to 100 of about 4,757 (208)

Ellagic Acid Alleviates Abnormal Fat Reduction by Activating the RXRβ–PPARγ Pathways in a CT26 Tumour‐Induced Cachexia Mouse Model

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Cancer cachexia is a syndrome characterized by significant weight loss, particularly of adipose tissue, which negatively impacts patient survival. Pharmacological approaches to prevent this abnormal fat reduction remain poorly defined.
Woo Yong Park, Beomsu Kim, Gahee Song, Sang Hee Kim, Jin‐Hyung Kim, Ja Yeon Park, Se Jin Jung, Wenjun Jiao, Jisoo Han, Taekyoung Kong, Kwang Seok Ahn, Hyun Jeong Kwak, Jae‐Young Um   +12 more
wiley   +1 more source

The effects of polyphenols and other bioactives on human health [PDF]

, 2019
Although deficiencies in polyphenol intake do not result in specific deficiency diseases, adequate intake of polyphenols could confer health benefits, especially with regard to chronic diseases. Tea, cocoa, fruits, and berries, as well as vegetables, are
Croft, Kevin D., Fraga, César G., Kennedy, David, Tomás-Barberán, Francisco A.   +3 more
core   +3 more sources

CDK12 Inactivation Attenuates Prostate Cancer Progression by Inhibiting BNIP3‐Mediated Mitophagy

Cell Proliferation, Volume 59, Issue 2, February 2026.
In response to enzalutamide, damaged mitochondria are targeted for mitophagic degradation through the binding of BNIP3 to LC3, forming autophagosomes that are subsequently transported to lysosomes for degradation. These self‐protective mechanisms promote mitochondrial renewal, reduce oxidative stress and finally contribute to cancer cell survival ...
Mengjun Huang, Hanqi Lei, Tongyu Tong, Hailin Zou, Binyuan Yan, Fei Cao, Yiting Wang, Qiliang Teng, Bin Xu, Juan Luo, Yupeng Guan, Shaohong Lai, Peng Li, Jun Pang   +13 more
wiley   +1 more source

Hydrolysable tannin-based diet rich in gallotannins has a minimal impact on pig performance but significantly reduces salivary and bulbo-urethral gland size [PDF]

, 2017
Tannins have long been considered ‘anti-nutritional’ factors in monogastric nutrition, shown to reduce feed intake and palatability. However, recent studies revealed that compared to condensed tannins, hydrolysable tannins (HT) appear to have far less ...
Ampuero-Kragten, S., Bee, G., Litten-Brown, J., Mueller-Harvey, I., Salminen, J.-P., Silacci, P., Wealleans, A. L., Čandek-Potokar, M.   +7 more
core   +1 more source

Pulmonary Vascular Endothelial Cells in Lung Diseases: Mechanisms, Therapeutic Strategies, and Future Directions

Cell Proliferation, Volume 59, Issue 2, February 2026.
The pathogenic mechanisms of pulmonary vascular endothelial cells (VECs) in lung diseases and their multimodal therapeutic strategies. ABSTRACT Pulmonary vascular endothelial cells (VECs) are essential for the normal function of the lung, through maintaining vascular barrier integrity, regulating blood flow, and participating in inflammatory responses ...
Qianyue Liu, Hongshuai Zheng, Jing Liu, Ming Gao, Faquan Lin, Lin Liao   +5 more
wiley   +1 more source

Patient empowerment and the Mediterranean diet as a possible tool to tackle prediabetes associated with overweight or obesity: a pilot study [PDF]

, 2019
AIM: The objective of this study was to investigate the effect of implementation of short-term patient empowerment as applied to Mediterranean diet (MD) adherence on metabolic and anthropometric parameters in prediabetic overweight or obese subjects.
Altieri, B., Barrea, L., Colao, A., Di Somma, C., Muscogiuri, G., Orio, F., Savastano, S., Spinosa, T., Vecchiarini, M.   +8 more
core   +1 more source

Mitochondria‐associated membranes (MAMs): molecular organization, cellular functions, and their role in health and disease

FEBS Open Bio, Volume 16, Issue 1, Page 11-24, January 2026.
Mitochondria‐associated membranes (MAMs) are contact sites between the endoplasmic reticulum and mitochondria that regulate calcium signaling, lipid metabolism, autophagy, and stress responses. This review outlines their molecular organization, roles in cellular homeostasis, and how dysfunction drives neurodegeneration, metabolic disease, cancer, and ...
Viet Bui, Maryline Santerre, Natalia Shcherbik, Bassel E Sawaya   +3 more
wiley   +1 more source

Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster [PDF]

, 2017
The accumulation of dysfunctional mitochondria has been implicated in aging, but a deeper understanding of mitochondrial dynamics and mitophagy during aging is missing.
A Rana, A Tanaka, AC Poole, AC Poole, AM Pickrell, AS Rambold, B DuBoff, C Lopez-Otin, CC Yang, CQ Scheckhuber, D Mathur, D Ryu, DC Chan, DC David, DC Rubinsztein, DJ Klionsky, DP Narendra, DR Green, DW Walker, E Beregi, E Dambroise, E Lionaki, E Owusu-Ansah, E Smirnova, E Ziviani, ES Vincow, F Demontis, G Ashrafi, G Twig, G Twig, GD Cartee, H Abeliovich, H Deng, H Nakatogawa, I Pimenta de Castro, IP Castro de, J Durieux, J Park, J Yun, JM Copeland, JP Leduc-Gaudet, K Kavanagh, K Mao, K Palikaras, L Buhlman, L Partridge, L Poirier, M Frank, M Kaeberlein, M Manczak, M Rera, M Rera, M Schrader, MJ Drummond, N Sun, N Sun, N Thevaranjan, NC Chan, P Reis-Rodrigues, R Coleman, R Kandimalla, RH Houtkooper, RJ Youle, RJ Youle, S Geisler, S Gelino, S Hoppins, S Iqbal, SE Wohlgemuth, WW Ja, X Wang, Y Wang, Y Yang   +72 more
core   +6 more sources

Differential Effects of Whole Red Raspberry Polyphenols and Their Gut Metabolite Urolithin A on Neuroinflammation in BV-2 Microglia [PDF]

, 2020
Whole red raspberry polyphenols (RRW), including ellagic acid, and their gut-derived metabolite, urolithin A (UroA), attenuate inflammation and confer health benefits.
Albusharif, Mahaa, Chaidez, Virginia, Chung, Soonkyu, Polenz, Luke, Ramer-Tait, Amanda E., Schlange, Stacie, Toney, Ashley Mulcahy, Works, Duncan   +7 more
core   +5 more sources

Emerging Therapeutic Strategies in Anti‐Aging Medicine: A Comprehensive Review

Medicine Bulletin, Volume 2, Issue 1, Page 94-123, January 2026.
ABSTRACT Aging is orchestrated by interconnected hallmarks such as genomic instability, mitochondrial dysfunction, cellular senescence, and disrupted intercellular communication, which collectively drive chronic disease progression. Recent advances have expanded therapeutic opportunities to include pharmacological agents, gene and epigenome editing ...
Yundong Peng, Rui Li, Huan Li, Jun Zhou, Xuanshi Liu, Guilherme Valente, Tatiana de Campos Melo, Sifan Chen, Lei Gu   +8 more
wiley   +1 more source