Results 11 to 20 of about 4,757 (208)
Urolithins: Diet-Derived Bioavailable Metabolites to Tackle Diabetes [PDF]
Nutrients, 2021 Diabetes remains one of the leading causes of deaths and co-morbidities in the world, with tremendous human, social and economic costs. Therefore, despite therapeutics and technological advancements, improved strategies to tackle diabetes management are still needed. One of the suggested strategies is the consumption of (poly)phenols. Positive outcomes
Ana F. Raimundo +4 more
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Urolithin and Reduced Urolithin Derivatives as Potent Inhibitors of Tyrosinase and Melanogenesis: Importance of the 4-Substituted Resorcinol Moiety [PDF]
International Journal of Molecular Sciences, 2021 We previously reported (E)-β-phenyl-α,β-unsaturated carbonyl scaffold ((E)-PUSC) played an important role in showing high tyrosinase inhibitory activity and that derivatives with a 4-substituted resorcinol moiety as the β-phenyl group of the scaffold resulted in the greatest tyrosinase inhibitory activity.
Sanggwon Lee +13 more
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Urolithins and intestinal health
Drug Discoveries & Therapeutics, 2022 There are trillions of microorganisms in the human intestine. They can react to the intestinal microenvironment by metabolizing food or producing small molecular compounds to affect the host's digestive ability and resist the risk of infection and autoimmune diseases.
Chunhua, Lu +4 more
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Immunomodulatory Role of Urolithin A on Metabolic Diseases [PDF]
Biomedicines, 2021 Urolithin A (UroA) is a gut metabolite produced from ellagic acid-containing foods such as pomegranates, berries, and walnuts. UroA is of growing interest due to its therapeutic potential for various metabolic diseases based on immunomodulatory properties.
Ashley Mulcahy Toney +4 more
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Total Syntheses of Sappanin-Based Natural Products Enabled by Pattern Recognition Analysis and Brominative Aromatization. [PDF]
Chem Asian JA unified synthetic strategy enables the total syntheses of sappanin‐based natural products from a common privileged intermediate derived from cyclic vinylogous esters. Abstract Described is a concise route to caesappins A and B, urolithin C, and protosappanin A, which share a common sappanin core.
Zhao WT, Liang JY, Wu YK.
europepmc +2 more sources
Urolithins: A Prospective Alternative against Brain Aging
Nutrients, 2023 The impact of host–microbiome interactions on cognitive health and disease has received increasing attention. Microbial-derived metabolites produced in the gut are one of crucial mechanisms of the gut–brain axis interaction, showing attractive perspectives. Urolithins (Uros) are gut microbial-derived metabolites of ellagitannins and ellagic acid, whose
An, Lei +3 more
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Journal of Agricultural and Food Chemistry, 2023 Urolithins are gut microbiota metabolites of ellagic acid. Here, we have identified and chemically characterized a novel urolithin produced from urolithin D (3,4,8,9-tetrahydroxy urolithin) by in vitro incubation with different human gut Enterocloster species under anaerobic conditions. Urolithin G (3,4,8-trihydroxy urolithin) was identified by 1H NMR,
David Beltrán +7 more
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Urolithin A alleviates neuropathic pain and activates mitophagy
Molecular Pain, 2023 Neuropathic pain (NP) occurs frequently in the general population and has a negative impact on the quality of life. There is no effective therapy available yet owing to the complex pathophysiology of NP. In our previous study, we found that urolithin A (UA), a naturally occurring microflora-derived metabolite, could relieve NP in mice by inhibiting ...
Chenyi Wang +6 more
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Molecules, 2022 Ganlanye (GLY), the leaf of Canarium album (Lour.) DC., is a traditional Chinese medicinal herb for warm disease treatment. We found that its aqueous extract could inhibit the influenza A virus.
Mengjie Xiao +5 more
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Cells, 2022 In the current study, for the first time, we study mitophagy enhancer urolithin A and a combination of urolithin A+green tea extract EGCG against human Aβ peptide-induced mitochondrial and synaptic, dendritic, inflammatory toxicities and behavioral ...
Sudhir Kshirsagar +8 more
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