Results 41 to 50 of about 4,757 (208)

Muscadine or amla extracts standardized to ellagic acid content ameliorate glucolipotoxicity associated β-cell dysfunction via inhibition of IL-1β and improved insulin secretion

open access: yesFood Production, Processing and Nutrition, 2020
Glucolipotocixity induces IL-1 β secretion which impairs pancreatic β-cell insulin secretion. Ellagic acid and urolithin A have strong anti-inflammatory effect on cells. Muscadine and amla are very good sources of ellagic acid. The present study examined
Srikanth Earpina   +5 more
doaj   +1 more source

Inhibitory effect of tannins from galls of Carpinus tschonoskii on the degranulation of RBL-2H3 Cells [PDF]

open access: yes, 2012
In this study, the anti-allergy potency of thirteen tannins isolated from the galls on buds of Carpinus tschonoskii (including two tannin derivatives) was investigated.
Han Junkyu   +7 more
core   +1 more source

Digestive Stability of Tannin-Enriched Fraction of Rubus chingii Hu Fruits and Its Regulatory Effect on the Intestinal Microflora [PDF]

open access: yesShipin Kexue, 2023
Tannin is the major active ingredient of the dried unripe fruits of Chinese raspberry (Rubus chingii Hu), Fupenzi in Chinese, and has the functions of lowering blood sugar, reducing blood lipid, resisting inflammation, delaying aging and preventing ...
JIA Xiaoyan, HU Pengpeng, WANG Peixin, DING Qiao, WANG Enhui, XIE Zuohua, TU Zongcai, ZHANG Lu
doaj   +1 more source

Pomegranate ellagitannins inhibit α-glucosidase activity in vitro and reduce starch digestibility under simulated gastro-intestinal conditions [PDF]

open access: yes, 2014
Pomegranate extract was tested for its ability to inhibit α-amylase and α-glucosidase activity. Pomegranate extract strongly inhibited rat intestinal α-glucosidase in vitro whereas it was a weak inhibitor of porcine α-amylase. The inhibitory activity was
BELLESIA, ANDREA   +2 more
core   +1 more source

Antiproliferative effect of urolithin A, the ellagic acid-derived colonic metabolite, on hepatocellular carcinoma HepG2.2.15 cells by targeting Lin28a/let-7a axis

open access: yesBrazilian Journal of Medical and Biological Research, 2018
An abnormality in the Lin28/let-7a axis is relevant to the progression of hepatitis B virus (HBV)-positive hepatocellular carcinoma (HCC), which could be a novel therapeutic target for this malignant tumor.
Zhenpeng Qiu   +5 more
doaj   +1 more source

Isolation and characterization of a novel human intestinal Enterococcus faecium FUA027 capable of producing urolithin A from ellagic acid

open access: yesFrontiers in Nutrition, 2022
Urolithin A (UA) has received considerable research attention because of its health benefits. However, only a few strains have been reported to produce UA from ellagic acid (EA), and the molecular mechanisms underlying the gut microbiota-mediated ...
Xiaomeng Zhang   +20 more
doaj   +1 more source

Maternal pomegranate juice intake and brain structure and function in infants with intrauterine growth restriction: A randomized controlled pilot study. [PDF]

open access: yes, 2019
Polyphenol-rich pomegranate juice has been shown to have benefit as a neuroprotectant in animal models of neonatal hypoxic-ischemia. No published studies have investigated maternal polyphenol administration as a potential neuroprotectant in at-risk ...
Alexopoulos, Dimitrios   +7 more
core   +2 more sources

Urolithin A attenuates auditory cell senescence by activating mitophagy

open access: yesScientific Reports, 2022
AbstractAging of sensory organs is associated with a decline in mitochondrial function and the accumulation of dysfunctional mitochondria. Impaired mitophagy blocks the turnover of dysfunctional mitochondria and leads to their accumulation. Urolithin A (UA) induces mitophagy in various mammalian cells.
Sung Il Cho, Eu-Ri Jo, Hansoo Song
openaire   +3 more sources

Microbial Phenolic Metabolites in Urine Are Inversely Linked to Certain Features of Metabolic Syndrome in Spanish Adolescents

open access: yesAntioxidants, 2022
(1) Background: To explore the association between microbial phenolic metabolites (MPM) and metabolic syndrome (MetS) and its clinical features in adolescents aged 12.02 ± 0.41 years. (2) Methods: a cross-sectional study was conducted in 560 participants
Emily P. Laveriano-Santos   +16 more
doaj   +1 more source

Gut microbiota modulation of chemotherapy efficacy and toxicity [PDF]

open access: yes, 2017
Evidence is growing that the gut microbiota modulates the host response to chemotherapeutic drugs, with three main clinical outcomes: facilitation of drug efficacy; abrogation and compromise of anticancer effects; and mediation of toxicity.
Alexander, James L.   +5 more
core   +1 more source

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