Gut metabolite Urolithin A mitigates ionizing radiation‐induced intestinal damage [PDF]
Journal of Cellular and Molecular Medicine, 2021 AbstractIonizing radiation (IR)‐induced intestinal damage is the major and common injury of patients receiving radiotherapy. Urolithin A (UroA) is a metabolite of the intestinal flora of ellagitannin, a compound found in fruits and nuts such as pomegranates, strawberries and walnuts.
Yuanyang Zhang +7 more
openaire +2 more sources
Exploration of Novel Urolithin C Derivatives as Non-Competitive Inhibitors of Liver Pyruvate Kinase
Pharmaceuticals, 2023 The inhibition of liver pyruvate kinase could be beneficial to halt or reverse non-alcoholic fatty liver disease (NAFLD), a progressive accumulation of fat in the liver that can lead eventually to cirrhosis.
Umberto Maria Battisti +12 more
doaj +1 more source
Consumption of watermelon juice enriched in L-citrulline and pomegranate ellagitannins enhanced metabolism during physical exercise [PDF]
, 2017 L-Citrulline is a nonessential amino acid precursor of arginine and indirectly a precursor of nitric oxide (NO), which is a vasodilator and increases mitochondrial respiration.
Aguayo, Encarna +5 more
core +2 more sources
Urolithin-A attenuates neurotoxoplasmosis and alters innate response towards predator odor
Brain, Behavior, & Immunity - Health, 2020 Neurotoxoplasmosis, also known as cerebral toxoplasmosis, is an opportunistic chronic infection caused by the persistence of parasite Toxoplasma gondii cysts in the brain.
Sijie Tan, Wen Han Tong, Ajai Vyas
doaj +1 more source
Perspective: Metabotyping-A Potential Personalized Nutrition Strategy for Precision Prevention of Cardiometabolic Disease [PDF]
, 2019 Diet is an important, modifiable lifestyle factor of cardiometabolic disease risk, and an improved diet can delay or even prevent the onset of disease.
Agneta, Rostgaard-Hansen,, +15 more
core +1 more source
Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols [PDF]
, 2017 (Poly)phenols are a large group of compounds, found in food, beverages, dietary supplements and herbal medicines. Owing to their biological activities, absorption and metabolism of the most abundant compounds in humans are well understood.
Actis-Goretta +182 more
core +1 more source
A widely distributed metalloenzyme class enables gut microbial metabolism of host- and diet-derived catechols. [PDF]
, 2020 Catechol dehydroxylation is a central chemical transformation in the gut microbial metabolism of plant- and host-derived small molecules. However, the molecular basis for this transformation and its distribution among gut microorganisms are poorly ...
Balskus, Emily P +8 more
core +1 more source
Microorganisms, 2023 The probiotic Weizmannia coagulans (W. coagulans) BC2000 can increase the abundance of intestinal transforming ellagic acid (EA) bacteria and inhibit metabolic disorders caused by hyperlipidemia by activating liver autophagy.
Long Jin +5 more
doaj +1 more source
Exploring the role of LDH in cancer cells through the use of small-molecule inhibitors. [PDF]
, 2018 Metabolic reprogramming represents a potential therapeutic target in cancer. The studies of this thesis work lead to assume the enzyme lactate dehydrogenase (LDH) as key element coordinating neoplastic proliferation and invasive growth, suggesting for ...
Di Ianni, Lorenza <1987>
core +1 more source
Therapeutic Potential of Mitophagy-Inducing Microflora Metabolite, Urolithin A for Alzheimer's Disease [PDF]
, 2021 Mitochondrial dysfunction including deficits of mitophagy is seen in aging and neurodegenerative disorders including Alzheimer's disease (AD). Apart from traditionally targeting amyloid beta (Aβ), the main culprit in AD brains, other approaches include ...
Fernando B +9 more
core +2 more sources