Results 81 to 90 of about 4,757 (208)

The effects of a (poly)phenol‐rich food intervention on markers of exercise‐induced inflammation and oxidative stress: A randomised controlled trial

Experimental Physiology, EarlyView.
Abstract This study examined whether consuming a (poly)phenol‐rich food before strenuous muscle‐damaging exercise can modify post‐exercise markers of inflammation and oxidative stress. Using a double‐blinded, randomised, placebo‐controlled, between‐subjects design, 26 recreationally active males (n = 15) and females (n = 11) consumed higher‐(poly ...
Abrar Al Hebshi, Josh Thorley, Ana Rodriguez‐Mateos, Zicheng Zhang, Lewis J James, Tom Clifford   +5 more
wiley   +1 more source

In vivo administration of gut bacterial consortia replicates urolithin metabotypes A and B in a non-urolithin-producing rat model

Food & Function, 2023
The two bacterial consortia colonized the intestine of rats and converted UM-0 (non-urolithin-producing) animals into urolithin-producing animals mimicking the UM-A and UM-B metabotypes.
Carlos E. Iglesias-Aguirre, Antonio González-Sarrías, Adrián Cortés-Martín, María Romo-Vaquero, Leire Osuna-Galisteo, José Joaquín Cerón, Juan Carlos Espín, María Victoria Selma   +7 more
openaire   +2 more sources

The hope and hype of ellagic acid and urolithins as ligands of SARS-CoV-2 Nsp5 and inhibitors of viral replication

Journal of Enzyme Inhibition and Medicinal Chemistry, 2023
Non-structural protein 5 (Nsp5) is a cysteine protease that plays a key role in SARS-CoV-2 replication, suppressing host protein synthesis and promoting immune evasion.
Elisa Bianconi, Anna Gidari, Maria Souma, Samuele Sabbatini, Deborah Grifagni, Carlo Bigiotti, Elisabetta Schiaroli, Lucia Comez, Alessandro Paciaroni, Francesca Cantini, Daniela Francisci, Antonio Macchiarulo   +11 more
doaj   +1 more source

Targeting the Nrf2/TGF‐β1/Smad Signaling Pathway: A Novel Strategy for Urolithin A to Alleviate Renal Fibrosis

Food Frontiers, Volume 7, Issue 2, March 2026.
The diagram of the mechanism of action by which UroA regulates RF. ABSTRACT The global prevalence and mortality rates associated with chronic kidney disease (CKD) have been on a continuous rise over recent decades. Renal fibrosis (RF) serves as a critical factor in the progression of CKD to end‐stage renal disease.
Xue Wu, Jiating Li, Yonghui Dong, Jia Li, Ji Bian, Chao Liu, Hongbo Zhang, Lin Han, Min Wang   +8 more
wiley   +1 more source

Urolithins and their possible implications for diabetic kidney

European Journal of Translational and Clinical Medicine, 2022
The increasing prevalence of diabetic kidney disease (DKD), a common complication of type 1 and type 2 diabetes, is becoming a leading risk factor of developing end stage renal disease (ESRD). The multiple mechanisms involved in renal tissue damage are a challenge for effective targeted therapy.
Milena Kotewicz, Barbara Lewko
openaire   +2 more sources

The role of polyphenols in modern nutrition [PDF]

, 2017
Polyphenols are found in plant-based foods and beverages, notably apples, berries, citrus fruit, plums, broccoli, cocoa, tea and coffee, and many others. There is substantial epidemiological evidence that a diet high in polyphenol-rich fruit, vegetables,
Actis-Goretta, Actis-Goretta, Arab, Bakuradze, Bhupathiraju, Borges, Brull, Brull, Buitrago-Lopez, Buscemi, Buscemi, Cermak, Cifuentes-Gomez, Conquer, Cooper, Crippa, Ding, Ding, Dower, Dower, Drezner, EFSA NDA Panel (European Food Safety Authority Panel on Dietetic Products, Nutrition and Allergies), Egert, Egert, Ellam, Esposito, Fumeaux, Garcia-Alvarez, Guo, Guo, Hara, Heiss, Hertog, Hollman, Hooper, Hubbard, Jaganath, Jimenez, Jumar, Kay, Kempf, Kerimi, Kim, Lee, Leveques, Loke, Martin, Martini, Mastroiacovo, McAnulty, Mullen, Neilson, Neveu, Nieman, Nishimuro, Olthof, Olthof, Ottaviani, Ottaviani, Pan, Pang, Peluso, Perez-Jimenez, Petri, Pimpao, Pinto, Rhee, Rio, Romo-Vaquero, Santesso, Santos, Scalbert, Schmit, Serafini, Shaposhnikov, Shi, Shi, Stoupi, Urgert, Urgert, Vargas-Murga, Vlachojannis, Vogiatzoglou, Vogiatzoglou, Watanabe, Williamson, Williamson, Williamson, Woodward, Yahya, Yang, Yang, Yang, Zock   +93 more
core   +1 more source

Microbial‐Immune Interplay in CNS Autoimmune Diseases: Lessons from Animal Models and Clinical Studies

European Journal of Immunology, Volume 56, Issue 2, February 2026.
Mechanism of action of the intestinal microbiota on CNS autoimmune diseases. Environmental factors shape gut microbiota composition; dysbiosis alters microbial metabolites and antigenic signals. These modulate innate and adaptive immunity, affect barrier integrity, and influence CNS‐resident cells such as microglia and astrocytes, contributing to ...
Matteo Ceccon, Francesca Ronchi
wiley   +1 more source

Isolation and characterization of urolithin b from asphaltum [PDF]

Journal of Pharmacognosy and Phytochemistry, 2019
Asphaltum (vernacular name: Shilajit), is a traditional Ayurvedic medicine used as aphrodisiac. The present study was aimed for extraction, isolation, method development and validation of RP-HPLC method for bioactive compound called urolithin B (benzocoumarin) for Asphaltum. HPLC method was developed with the help of PDA detector for isolated compound.
Shefali Thakkar, Kirti Laddha
openaire   +1 more source

Benefits of polyphenols on gut microbiota and implications in human health [PDF]

, 2017
The biological properties of dietary polyphenols are greatly dependent on their bioavailability that, in turn, is largely influenced by their degree of polymerization.
Andrés Lacueva, Ma. Cristina, Cardona, Fernando, Queipo Ortuño, María Isabel, Tinahones, Francisco J., Tulipani, Sara   +4 more
core   +1 more source

Bioactive Phenolic Compounds in Extra Virgin Olive Oil: Implications for Cardiovascular Health

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Extra virgin olive oil (EVOO) is rich in bioactive polyphenols that exert antioxidant, anti‐inflammatory, and anti‐atherogenic effects. These compounds improve endothelial function, modulate lipid metabolism, and reduce platelet aggregation, contributing to cardiovascular protection. Regular consumption of phenolic‐rich EVOO, as part of a Mediterranean
Cristina Vázquez‐Jiménez, Mª. Dolores Rodríguez‐Pérez, Laura Ortega‐Hombrados, Ana María Sánchez‐Tévar, José Pedro de la Cruz‐Cortés, José A. Gonzalez‐Correa   +5 more
wiley   +1 more source