High PEEP Activates ITGB1, Inducing Diaphragm Fibrosis During Prolonged Mechanical Ventilation [PDF]
BiomoleculesBackground: Mechanical ventilation (MV) with high positive end-expiratory pressure (PEEP) is linked to ventilation-induced diaphragm dysfunction (VIDD), but the role of integrin beta-1 (ITGB1) in PEEP-associated diaphragm fibrosis remains unclear ...
Jiahong Gong +9 more
doaj +2 more sources
Phrenic nerve stimulation to prevent diaphragmatic dysfunction and ventilator-induced lung injury [PDF]
Intensive Care Medicine Experimental, 2023 Side effects of mechanical ventilation, such as ventilator-induced diaphragmatic dysfunction (VIDD) and ventilator-induced lung injury (VILI), occur frequently in critically ill patients.
Alessandro Panelli +4 more
doaj +2 more sources
Electrical stimulation mitigates muscle degradation shift in gene expressions during 12-h mechanical ventilation [PDF]
Scientific Reports, 2023 Ventilator-induced diaphragm dysfunction (VIDD), a dysfunction of the diaphragm muscle caused by prolonged mechanical ventilation (MV), is an important factor that hinders successful weaning from ventilation.
Hideki Nakai +3 more
doaj +2 more sources
Noise and HealthObjectives: This study aimed to investigate the effect of noise control care on emotional state and sleep quality in patients with ventilator-induced diaphragmatic dysfunction (VIDD).
ZhiYun Qiu, Wei Zhang, ZhuLin Yan
doaj +2 more sources
Antioxidants, 2023 Mechanical ventilation during cardiothoracic surgery is life-saving but can lead to ventilator-induced diaphragm dysfunction (VIDD) and prolong ventilator weaning and hospital length of stay.
Ashley Smuder +2 more
exaly +3 more sources
Livsfrågornas vidd, hoppets möjlighet
HYBRID – mellan akademi, kyrka & samhälleArtikeln diskuterar hur de stora frågorna om livsmeningen tas upp i fyra romaner av Lars Andersson från åren 2008–2017. Där bryts de individuella människornas svårigheter mot ett möjligt hopp om mening med utgångspunkt i en gudomlig nåd. Som sidobelysningar används Anderssons egna essäer i närliggande ämnen, samt naturligtvis några andra forskares ...
exaly +2 more sources
Single-nucleus transcriptomic profiling of the diaphragm during mechanical ventilation [PDF]
Scientific ReportsMechanical ventilation contributes to diaphragm atrophy and muscle weakness, which is referred to as ventilator-induced diaphragmatic dysfunction (VIDD). The pathogenesis of VIDD has not been fully understood until recently.
Lei Li +5 more
doaj +2 more sources
Frontiers in Cell and Developmental Biology, 2022 Critical illness myopathy (CIM) and ventilator-induced diaphragm dysfunction (VIDD) are characterized by severe muscle wasting, muscle paresis, and extubation failure with subsequent increased medical costs and mortality/morbidity rates in intensive care
Lars Larsson, Wen Ya, Larsson Lars
exaly +3 more sources
Commentary on 'Irisin Attenuates Ventilator-Induced Diaphragmatic Dysfunction by Inhibiting Endoplasmic Reticulum Stress Through Activation of AMPK'. [PDF]
J Cell Mol MedJournal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
Li W, Yang H, Li J, Xu X.
europepmc +2 more sources
Multi-center randomized superiority clinical trial in the early phase of mechanically ventilated patients to preserve diaphragm thickness using non-invasive magnetic phrenic nerve stimulation: STIMIT ACTIVATOR 1 pivotal trial [PDF]
TrialsBackground Ventilator-induced diaphragmatic dysfunction (VIDD) occurs in up to 60% of mechanically ventilated patients and prolongs ventilatory dependance.
Annia F. Schreiber +16 more
doaj +2 more sources