Results 21 to 30 of about 559 (125)

Mechanosensitive Piezo1 Channels Mediate Diaphragm Fibrosis Induced by Prolonged Mechanical Ventilation. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Background Ventilator‐induced diaphragmatic dysfunction (VIDD) is a major complication in critically ill patients. Prolonged mechanical ventilation (MV) triggers diaphragmatic fibrotic remodelling, but the underlying mechanisms remain unclear. This study investigated the role of the mechanosensitive channel Piezo1 in this process.
Xie D, Xiao Y, Li X, Sun B, Feng J, Jia J, Li J, Wang Y, He F, Liu L.   +9 more
europepmc   +2 more sources

Comparative Efficacy of Angiotensin II Type 1 Receptor Blockers Against Ventilator‐Induced Diaphragm Dysfunction in Rats

Clinical and Translational Science, 2021
Mechanical ventilation (MV) is a life‐saving intervention for many critically ill patients. Unfortunately, prolonged MV results in the rapid development of inspiratory muscle weakness due to diaphragmatic atrophy and contractile dysfunction (termed ...
Stephanie E. Hall, Bumsoo Ahn, Ashley J. Smuder, Aaron B. Morton, J. Matthew Hinkley, Michael P. Wiggs, Kurt J. Sollanek, Hayden Hyatt, Scott K. Powers   +8 more
doaj   +1 more source

Vidd og presisjon om kropp og person

Norsk Filosofisk Tidsskrift, 2005
exaly   +2 more sources

Angiotensin 1‐7 protects against ventilator‐induced diaphragm dysfunction

Clinical and Translational Science, 2021
Mechanical ventilation (MV) is a life‐saving instrument used to provide ventilatory support for critically ill patients and patients undergoing surgery.
Toshinori Yoshihara, Rafael Deminice, Hayden W. Hyatt, Mustafa Ozdemir, Branden L. Nguyen, Scott K. Powers   +5 more
doaj   +1 more source

Irisin attenuates ventilator-induced diaphragmatic dysfunction by inhibiting endoplasmic reticulum stress through activation of AMPK. [PDF]

J Cell Mol Med
Abstract Mechanical ventilation (MV) is an essential life‐saving technique, but prolonged MV can cause significant diaphragmatic dysfunction due to atrophy and decreased contractility of the diaphragm fibres, called ventilator‐induced diaphragmatic dysfunction (VIDD).
Zhang J, Tu R, Guan F, Feng J, Jia J, Zhou J, Wang X, Liu L.   +7 more
europepmc   +2 more sources

Hydrogen sulfide donor protects against mechanical ventilation‐induced atrophy and contractile dysfunction in the rat diaphragm

Clinical and Translational Science, 2021
Mechanical ventilation (MV) is a clinical tool providing adequate alveolar ventilation in patients that require respiratory support. Although a life‐saving intervention for critically ill patients, prolonged MV results in the rapid development of ...
Noriko Ichinoseki‐Sekine, Ashley J. Smuder, Aaron B. Morton, James M. Hinkley, Andres Mor Huertas, Scott K. Powers   +5 more
doaj   +1 more source

Effects of Visual Active Deceleration Devices on Controlling Vehicle Speeds in a Long Downhill Tunnel of an Expressway

Applied Sciences, 2021
Because the inside of a road tunnel is a closed strip, the driving environment changes suddenly at the tunnel entrance and exit, which is why accidents occur more frequently in tunnels than elsewhere.
Fu Wang, Dengjun Gu, Yuanyuan Li, Wei Liu, Guoyun Wang, Naikan Ding   +5 more
doaj   +1 more source

Diaphragm Function in Very Preterm Infants at 36 Weeks' Postmenstrual Age. [PDF]

Pediatr Pulmonol
ABSTRACT Objectives Understand how bronchopulmonary dysplasia (BPD) and antenatal and postnatal factors influence diaphragmatic functional effectiveness in very preterm infants. Working Hypothesis Diaphragmatic functional effectiveness during spontaneous breathing is impaired in infants with BPD.
Stoecklin B, Al-Obaidi Z, Svedenkrans J, Dellacà R, Pillow JJ.   +4 more
europepmc   +2 more sources

Calpains play an essential role in mechanical ventilation-induced diaphragmatic weakness and mitochondrial dysfunction

Redox Biology, 2021
Mechanical ventilation (MV) is a life-saving intervention for many critically ill patients. Unfortunately, an unintended consequence of prolonged MV is the rapid development of diaphragmatic atrophy and contractile dysfunction, known as ventilator ...
Hayden W. Hyatt, Mustafa Ozdemir, Toshinori Yoshihara, Branden L. Nguyen, Rafael Deminice, Scott K. Powers   +5 more
doaj   +1 more source

Disturbances in Calcium Homeostasis Promotes Skeletal Muscle Atrophy: Lessons From Ventilator-Induced Diaphragm Wasting

Frontiers in Physiology, 2020
Mechanical ventilation (MV) is often a life-saving intervention for patients in respiratory failure. Unfortunately, a common and undesired consequence of prolonged MV is the development of diaphragmatic atrophy and contractile dysfunction.
Hayden W. Hyatt, Scott K. Powers
doaj   +1 more source