Palmitoylation of Voltage-Gated Ion Channels. [PDF]
Int J Mol Sci, 2022 Protein lipidation is one of the most common forms of posttranslational modification. This alteration couples different lipids, such as fatty acids, phospho- and glycolipids and sterols, to cellular proteins. Lipidation regulates different aspects of the protein’s physiology, including structure, stability and affinity for cellular membranes and ...
Cassinelli S +5 more
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Regulating voltage-gated ion channels with nanobodies [PDF]
Nature Communications, 2022 In this work, Morgenstern and colleagues describe an approach involving functionalized nanobodies which decrease the activity of voltage-gated Ca2+ channels associated with β1 subunits and promote their removal from the surface membrane of neurons and ...
Declan Manning, L. Fernando Santana
doaj +6 more sources
Thermodynamics of voltage-gated ion channels. [PDF]
Biophys Rep, 2018 Ion channels are essential for cellular signaling. Voltage-gated ion channels (VGICs) are the largest and most extensively studied superfamily of ion channels. They possess modular structural features such as voltage-sensing domains that encircle and form mechanical connections with the pore-forming domains.
Zhang XC, Yang H, Liu Z, Sun F.
europepmc +5 more sources
Actions and Mechanisms of Polyunsaturated Fatty Acids on Voltage-Gated Ion Channels. [PDF]
Front Physiol, 2017 Polyunsaturated fatty acids (PUFAs) act on most ion channels, thereby having significant physiological and pharmacological effects. In this review we summarize data from numerous PUFAs on voltage-gated ion channels containing one or several voltage ...
Elinder F, Liin SI.
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Optical electrophysiology for probing function and pharmacology of voltage-gated ion channels [PDF]
eLife, 2016 Voltage-gated ion channels mediate electrical dynamics in excitable tissues and are an important class of drug targets. Channels can gate in sub-millisecond timescales, show complex manifolds of conformational states, and often show state-dependent ...
Hongkang Zhang +2 more
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Regulation of pain neurotransmitters and chondrocytes metabolism mediated by voltage-gated ion channels: A narrative review [PDF]
Heliyon, 2023 Osteoarthritis (OA) is one of the leading causes of chronic pain and dysfunction. It is essential to comprehend the nature of pain and cartilage degeneration and its influencing factors on OA treatment. Voltage-gated ion channels (VGICs) are essential in
Xinwei Wang, Xueping Li
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Voltage-Gated Lipid Ion Channels. [PDF]
PLoS ONE, 2013 Synthetic lipid membranes can display channel-like ion conduction events even in the absence of proteins. We show here that these events are voltage-gated with a quadratic voltage dependence as expected from electrostatic theory of capacitors.
Andreas Blicher, Thomas Heimburg
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Pulsed Electric Fields Can Create Pores in the Voltage Sensors of Voltage-Gated Ion Channels. [PDF]
Biophys J, 2020 Pulsed electric fields are increasingly used in medicine to transiently increase the cell membrane permeability via electroporation to deliver therapeutic molecules into the cell.
Rems L +3 more
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A Tale of Toxin Promiscuity: The Versatile Pharmacological Effects of Hcr 1b-2 Sea Anemone Peptide on Voltage-Gated Ion Channels [PDF]
Marine Drugs, 2022 Sea anemones are a rich source of biologically active compounds. Among approximately 1100 species described so far, Heteractis crispa species, also known as sebae anemone, is native to the Indo-Pacific area.
Ernesto Lopes Pinheiro-Junior +5 more
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THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Voltage-gated ion channels. [PDF]
Br J Pharmacol, 2017 The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to an open access knowledgebase of drug targets and ...
Alexander SP +11 more
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