Results 1 to 10 of about 132,798 (291)
Regulating voltage-gated ion channels with nanobodies. [PDF]
Nat Commun, 2022 In this work, Morgenstern and colleagues describe an approach involving functionalized nanobodies which decrease the activity of voltage-gated Ca(2+) channels associated with β(1) subunits and promote their removal from the surface membrane of neurons and muscle.
Manning D, Santana LF.
europepmc +6 more sources
Voltage Gated Lipid Ion Channels [PDF]
Biophysical Journal, 2013 10 pages, 7 figures - Strongly revised version compared to first version.
Blicher, Andreas +1 more
openaire +7 more sources
Palmitoylation of Voltage-Gated Ion Channels. [PDF]
Int J Mol Sci, 2022 Protein lipidation is one of the most common forms of posttranslational modification. This alteration couples different lipids, such as fatty acids, phospho- and glycolipids and sterols, to cellular proteins. Lipidation regulates different aspects of the protein’s physiology, including structure, stability and affinity for cellular membranes and ...
Cassinelli S +5 more
europepmc +3 more sources
Thermodynamics of voltage-gated ion channels. [PDF]
Biophys Rep, 2018 Ion channels are essential for cellular signaling. Voltage-gated ion channels (VGICs) are the largest and most extensively studied superfamily of ion channels. They possess modular structural features such as voltage-sensing domains that encircle and form mechanical connections with the pore-forming domains.
Zhang XC, Yang H, Liu Z, Sun F.
europepmc +4 more sources
Ionic selectivity and thermal adaptations within the voltage-gated sodium channel family of alkaliphilic Bacillus [PDF]
eLife, 2014 Entry and extrusion of cations are essential processes in living cells. In alkaliphilic prokaryotes, high external pH activates voltage-gated sodium channels (Nav), which allows Na+ to enter and be used as substrate for cation/proton antiporters ...
Clapham, David E +4 more
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Actions and Mechanisms of Polyunsaturated Fatty Acids on Voltage-Gated Ion Channels. [PDF]
Front Physiol, 2017 Polyunsaturated fatty acids (PUFAs) act on most ion channels, thereby having significant physiological and pharmacological effects. In this review we summarize data from numerous PUFAs on voltage-gated ion channels containing one or several voltage ...
Elinder F, Liin SI.
europepmc +2 more sources
Surface dynamics of voltage-gated ion channels. [PDF]
Channels (Austin), 2016 Neurons encode information in fast changes of the membrane potential, and thus electrical membrane properties are critically important for the integration and processing of synaptic inputs by a neuron. These electrical properties are largely determined by ion channels embedded in the membrane.
Heine M +4 more
europepmc +4 more sources
Voltage-Gated Ion Channels [PDF]
IEEE Transactions on Nanobioscience, 2005 Voltage-dependent ion channels are membrane proteins that conduct ions at high rates regulated by the voltage across the membrane. They play a fundamental role in the generation and propagation of the nerve impulse and in cell homeostasis. The voltage sensor is a region of the protein bearing charged amino acids that relocate upon changes in the ...
Sands, Z, Grottesi, A, Sansom, MS
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Executive Privilege in the Federal Courts [PDF]
, 1962 Apoptosis is one type of programmed cell death, important during tissue development and to maintain the tissue homeostasis. Apoptosis comprises a complex network of internal signaling pathways, and an important part of this signaling network is the ...
null null, Ulrika Englund
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Strategies for studying permeation at voltage-gated ion channels [PDF]
, 1991 Voltage-dependent ion channels are presently thought to consist of several distinct functional regions: (a) activation gates, (b) inactivation gates, and permeation pathways.
Lester, Henry A.
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