Results 11 to 20 of about 5,118,873 (324)
Oncogene, 2016 Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has most prominently been described for colorectal cancer, but aberrant Wnt ...
T. Zhan, Niklas Rindtorff, M. Boutros
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WNT Signaling in Melanoma [PDF]
International Journal of Molecular Sciences, 2020 WNT-signaling controls important cellular processes throughout embryonic development and adult life, so any deregulation of this signaling can result in a wide range of pathologies, including cancer.
A. Gajos-Michniewicz, M. Czyż
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Wnt signaling and cancer. [PDF]
Genes & Development, 2000 The regulation of cell growth and survival can be subverted by a variety of genetic defects that alter transcriptional programs normally responsible for controlling cell number. High throughput analysis of these gene expression patterns should ultimately
P. Polakis
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WNT Signaling in Disease [PDF]
Cells, 2019 Developmental signaling pathways control a vast array of biological processes during embryogenesis and in adult life. The WNT pathway was discovered simultaneously in cancer and development.
L. Ng +7 more
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Rethinking WNT signalling [PDF]
Nature, 2018 The identification of genetic mutations that can hinder the development of human limbs has led to the discovery of an unanticipated mode of regulation for the WNT signalling pathway during limb development. The identification of genetic mutations that can hinder the development of human limbs has led to the discovery of an unanticipated mode of ...
Jessica A, Lehoczky, Clifford J, Tabin
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Cell Research, 2011 Wnt signaling is a highly conserved and context-dependent signal transduction pathway that belongs to the so-called morphogens. Wnt signals are instrumental during development, but also play a central role in tissue homeostasis. For instance, in the intestine Wnt signaling is crucial for both stem cell maintenance and proliferation in the transient ...
de Sousa E Melo, Felipe +1 more
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WNT signaling and cancer stemness
Essays in Biochemistry, 2022 Cancer stemness, defined as the self-renewal and tumor-initiation potential of cancer stem cells (CSCs), is a cancer biology property featuring activation of CSC signaling networks.
Masuko Katoh, M. Katoh
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Wnt signalling: conquering complexity [PDF]
Development, 2018 ABSTRACT The history of the Wnt pathway is an adventure that takes us from mice and flies to frogs, zebrafish and beyond, sketching the outlines of a molecular signalling cascade along the way. Here, we specifically highlight the instrumental role that developmental biology has played throughout. We take the reader on a journey, starting
Katrin E. Wiese +2 more
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LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence
Frontiers in Cell and Developmental Biology, 2021 The canonical Wnt/β-catenin signaling plays a fundamental role in regulating embryonic development, injury repair and the pathogenesis of human diseases.
Qian Ren, Jiongcheng Chen, Youhua Liu
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Wnt signaling in cancer. [PDF]
Cold Spring Harbor Perspectives in Biology, 2012 Aberrant regulation of the Wnt signaling pathway is a prevalent theme in cancer biology. From the earliest observation that Wnt overexpression could lead to malignant transformation of mouse mammary tissue to the most recent genetic discoveries gleaned from tumor genome sequencing, the Wnt pathway continues to evolve as a central mechanism in cancer ...
P. Polakis
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