Comprehensive Expression of Wnt Signaling Pathway Genes during Development and Maturation of the Mouse Cochlea. [PDF]
PLoS ONE, 2016 In the inner ear Wnt signaling is necessary for proliferation, cell fate determination, growth of the cochlear duct, polarized orientation of stereociliary bundles, differentiation of the periotic mesenchyme, and homeostasis of the stria vascularis.
Ruishuang Geng +5 more
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WNT Signaling in Melanoma [PDF]
International Journal of Molecular Sciences, 2020 WNT-signaling controls important cellular processes throughout embryonic development and adult life, so any deregulation of this signaling can result in a wide range of pathologies, including cancer. WNT-signaling is classified into two categories: β-catenin-dependent signaling (canonical pathway) and β-catenin-independent signaling (non-canonical ...
Anna Gajos-Michniewicz, Malgorzata Czyz
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Expression Levels of WNT Signaling Pathway Genes During Early Tooth Development
Organogenesis, 2023 It is known to all that Wnt signaling pathway plays an important role in the early development of tooth. Our previous research found that Wnt signaling pathway played crucial roles in dental development, and mutations in antagonist of Wnt signaling ...
Yuhan Song +4 more
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Frontiers in Physiology, 2019 Studies support that regular physical activity (PA) decelerates senescence-related decline of physiological and molecular parameters in the elderly. We have addressed the other end of this spectrum: healthy and young, inactive individuals participated in
Kitti Garai +15 more
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Nkd1 functions as a passive antagonist of Wnt signaling. [PDF]
PLoS ONE, 2013 Wnt signaling is involved in many aspects of development and in the homeostasis of stem cells. Its importance is underscored by the fact that misregulation of Wnt signaling has been implicated in numerous diseases, especially colorectal cancer.
Diane Angonin, Terence J Van Raay
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Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids. [PDF]
, 2019 During gastrulation, the pluripotent epiblast self-organizes into the 3 germ layers-endoderm, mesoderm and ectoderm, which eventually form the entire embryo.
Chhabra, Sapna +4 more
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WormBook, 2005 The use of Wnt ligands for signaling between cells is a conserved feature of metazoan development. Activation of Wnt signal transduction pathways upon ligand binding can regulate diverse processes including cell proliferation, migration, polarity, differentiation and axon outgrowth.
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Structure-based Discovery of Novel Small Molecule Wnt Signaling Inhibitors by Targeting the Cysteine-rich Domain of Frizzled. [PDF]
, 2015 Frizzled is the earliest discovered glycosylated Wnt protein receptor and is critical for the initiation of Wnt signaling. Antagonizing Frizzled is effective in inhibiting the growth of multiple tumor types.
Baday, Yiressy C +9 more
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Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth [PDF]
, 2017 Bone morphogenetic proteins (Bmp) are well-known to induce bone formation following chondrogenesis, but the direct role of Bmp signaling in the osteoblast lineage is not completely understood.
Bellido, Teresita +5 more
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Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis. [PDF]
, 2016 Mechanical force and Wnt signaling activate β-catenin-mediated transcription to promote proliferation and tissue expansion. However, it is unknown whether mechanical force and Wnt signaling act independently or synergize to activate β-catenin signaling ...
Benham-Pyle, Blair W +4 more
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