Results 121 to 130 of about 147,306 (350)

Integrated In Vitro and In Silico Characterization of 5‐Hydroxyferulic Acid: Antioxidant, Anti‐Inflammatory, Anti‐Hemolytic, and Cytotoxic Potential

Chemistry &Biodiversity, EarlyView.
ABSTRACT In the pursuit of novel antioxidant and anti‐inflammatory agents, we investigated 5‐hydroxyferulic acid (5‐OHFA), a hydroxylated derivative of the well‐known phenolic compound ferulic acid (FA). This study aimed to determine whether structural modification enhances the biological activity of FA.
Syrine Sakouhi, Sonia Ben Younes, Fatma Arrari, Afef Nahdi, Jalloul Bouajila, Abada Mhamdi   +5 more
wiley   +1 more source

Sulfite: Cytochrome \u3cem\u3ec\u3c/em\u3e Oxidoreductase from \u3cem\u3eThiobacillus novellus\u3c/em\u3e [PDF]

, 2000
Direct oxidation of sulfite to sulfate occurs in various photo- and chemotrophic sulfur oxidizing microorganisms as the final step in the oxidation of reduced sulfur compounds and is catalyzed by sulfite:cytochrome c oxidoreductase (EC1.8.2.1).
Bennett, Brian, Dahl, Christiane, Deutzmann, Rainer, Kappler, Ulrike, McEwan, Alistair G., Rethmeier, Jörg, Schwarz, Günter   +6 more
core   +1 more source

Dietary Berberine Reduced Oxido‐Inflammatory Stress in Rats' Livers and Kidneys, Supplemented from Prepuberty to Adulthood

ChemFoodChem, EarlyView.
Berberine (BER) demonstrates significant protective effects on the hepatorenal system in rats, mediated through various cellular and molecular mechanisms spanning from the prepubertal stage through adulthood. These mechanisms encompass antioxidant, anti‐inflammatory, and anti‐apoptotic activities, in addition to modulation of essential signalling ...
Solomon Owumi, Bayode Oluwawibe, Harieme Agbarogi, Moses T. Otunla, Uche Arunsi, Jesutosin O. Babalola, Chioma Irozuru, Chima Amadi, Ahmad Altayyar   +8 more
wiley   +1 more source

Simultaneous Electrochemical Determination of Uric Acid, Xanthine, and Hypoxanthine Using AgNPs/MIL-101(Cr) Modified Electrode

ECS Sensors Plus
This paper presents silver nanoparticles supported by the Matérial Institute Lavoisier-101 (AgNPs/MIL-101(Cr)) for electrochemical determination of uric acid (URA), xanthine (XAT), and hypoxanthine (HPX).
Nguyen Quang Man, Nguyen Ngoc Nghia, Vo Thi Khanh Ly, Nguyen Duc Vu Quyen, Le Thi Hoa, Ho Van Minh Hai, Le Van Thanh Son, Le Thi Hong Phong, Nguyen Dinh Luyen, Nguyen Chi Bao, Dinh Quang Khieu   +10 more
doaj   +1 more source

Synthesis and physical-chemical properties of 8-benzylidenhydrazino-1-(4-fluorobenzyl)theobromine derivatives

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2014
The aim of the work is thesynthesis and research of physical and chemical properties of earlier undescribed 1,8-disubstituted of theobromine, which are potential biologically active compounds.
D. G. Ivanchenko, M. I. Romanenko, E. V. Alexandrova, A. S. Korjova   +3 more
doaj   +1 more source

Mechanistic insights into xanthine oxidoreductase from development studies of candidate drugs to treat hyperuricemia and gout

JBIC Journal of Biological Inorganic Chemistry, 2014
Xanthine oxidoreductase (XOR), which is widely distributed from humans to bacteria, has a key role in purine catabolism, catalyzing two steps of sequential hydroxylation from hypoxanthine to xanthine and from xanthine to urate at its molybdenum cofactor (
T. Nishino, K. Okamoto
semanticscholar   +1 more source

Acyclic Nucleoside Phosphonates As Potential Inhibitors Of Plasmodium Falciparum Egress

Chemistry – A European Journal, EarlyView.
Exploration of the chemistry of acyclic nucleoside phosphonates allowed us to study structural diversity from the hit compound; biological evaluation and molecular docking were performed to decipher key interactions with the putative target. Abstract The emergence of drug‐resistant Plasmodium strains requires the development of novel antimalarial ...
Thomas Cheviet, Sharon Wein, Corinne Lionne, Yan Badji, Natacha Venturini, Rachel Cerdan, Suzanne Peyrottes   +6 more
wiley   +1 more source

Clinical and social aspects of dysmenorrhea development

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2019
Modern antibiotics and synthetic antimicrobial agents play a leading role in the treatment of bacterial infections. Despite their effectiveness, they cause a number of side effects, and thus the search for new antimicrobial and antifungal agents is ...
O. P. Dolhikh, M. I. Romanenko, D. H. Ivanchenko, K. V. Aleksandrova, N. M. Polishchuk   +4 more
doaj   +1 more source

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Multiple Ascending Doses and Dose Titration of Bexicaserin in Healthy Participants in a Randomized, Double‐Blind, Placebo‐Controlled Study

Clinical Pharmacology in Drug Development, EarlyView.
Abstract Bexicaserin (LP352) is a selective superagonist of the 5‐hydroxytryptamine 2C (5‐HT2C) receptor currently in development for the treatment of seizures that arise from developmental and epileptic encephalopathies. This phase 1, double‐blind, placebo‐controlled multiple ascending dose (MAD) study assessed the safety, tolerability, and ...
Jonathan Williams, Rosa Chan, Chad Orevillo, Gale O'Connell, Dewey McLin, Shikha Polega, Nuggehally R. Srinivas, Randall Kaye   +7 more
wiley   +1 more source

Measurement and Characterization of Superoxide Generation from Xanthine Dehydrogenase: A Redox-Regulated Pathway of Radical Generation in Ischemic Tissues

Biochemistry, 2014
The enzyme xanthine oxidoreductase (XOR) is an important source of oxygen free radicals and related postischemic injury. Xanthine dehydrogenase (XDH), the major form of XOR in tissues, can be converted to xanthine oxidase (XO) by oxidation of sulfhydryl ...
Masaichi-chang-il Lee, M. Velayutham, T. Komatsu, R. Hille, J. Zweier   +4 more
semanticscholar   +1 more source