Results 41 to 50 of about 14,483 (182)

Alcohol exposure promotes cell communication network 1 cleavage in esophageal adenocarcinoma cells exclusively

open access: yesJournal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
An illustration shows how cell communication network 1 (CCN1) is involved in the normal esophagus, esophageal squamous cell carcinoma (ESCC), and esophageal adenocarcinoma (EAC) after alcohol exposure. Alcohol exposure upregulates CCN1 expression in the esophageal epithelium, with or without esophageal cancer. In normal individuals, CCN1 repairs tissue
Wula Aladan   +6 more
wiley   +1 more source

Chronic Cold Stress Alters the Skin Mucus Interactome in a Temperate Fish Model

open access: yesFrontiers in Physiology, 2019
Temperate fish are particularly sensitive to low temperatures, especially in the northern Mediterranean area, where the cold season decreases fish-farm production and affects fish health.
Ignasi Sanahuja   +4 more
doaj   +1 more source

Study of metalloproteinases in the blood of goats experimentally infected with caprine encephalitis arthritis virus

open access: yesSemina: Ciências Agrárias, 2020
Caprine arthritis encephalitis is a lentiviral disease that leads to considerable losses in goat farming. In the acute phase of viral infection, though antiviral antibodies are produced by the host’s immune system, they are not sufficient to be detected ...
Ylana Santos de Galiza   +6 more
doaj   +1 more source

Quantitation of the active alpha-2-macroglobulin by trypsin protease zymography [PDF]

open access: yesJournal of the Serbian Chemical Society, 2019
A simple and reliable method for the determination of the concentration and function of alpha-2-macroglobulin (α2M) by zymography was developed. The method is based on the covalent binding of α2M and trypsin followed by non-reducing PAGE and zymography ...
Gligorijević Nikola   +4 more
doaj   +1 more source

Therapeutic targeting of bleomycin‐induced pulmonary fibrosis by human bone marrow mesenchymal stem cell‐derived extracellular vesicles and/or pirfenidone: Impact of sex in mature adult mice

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 18, Page 5423-5439, September 2026.
Abstract Background and Purpose Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with limited therapeutic options. This study compared the therapeutic effects of bone marrow mesenchymal stem cell‐derived extracellular vesicles (BM‐MSC‐EVs) with an IPF treatment, pirfenidone (PFD), in mature adult mice with established pulmonary ...
Jennie S. Charoenphannathon   +4 more
wiley   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, Volume 20, Issue 8, Page 2085-2101, August 2026.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Upregulation of P2Y2R, Active uPA, and PAI-1 Are Essential Components of Hantavirus Cardiopulmonary Syndrome

open access: yesFrontiers in Cellular and Infection Microbiology, 2018
Sin Nombre virus (SNV) causes hantavirus cardiopulmonary pulmonary syndrome (HCPS) with the loss of pulmonary vascular endothelial integrity, and pulmonary edema without causing cytopathic effects on the vascular endothelium. HCPS is associated primarily
Virginie Bondu   +10 more
doaj   +1 more source

Neutrophil Gelatinase-associated Lipocalin, Cystatin C and Matrix Metalloproteinase-9 as Possible Biomarkers in Early Detection of Acute Kidney Injury after Cardiac Surgery [PDF]

open access: yesJournal of Clinical and Diagnostic Research, 2018
Introduction: Acute Kidney Injury (AKI) often occurs after open heart surgery. Today, serum creatinine is used as an indicator for identifying AKI; however, creatinine is unreliable due to delay in its elevation.
Sara Bagheri   +5 more
doaj   +1 more source

Integrated Network Analysis Suggests an miR‐21/MMP/VEGF‐Associated Regulatory Axis in Gastric Cancer

open access: yesCancer Reports, Volume 9, Issue 8, August 2026.
ABSTRACT Background, Aims Gastric cancer (GC) pathogenesis involves complex molecular interactions that remain incompletely understood at a biological systems level. While microRNA‐21 (miR‐21), matrix metalloproteinases (MMPs), and vascular endothelial growth factor (VEGF) have been individually implicated in GC, their integrated role as a coordinated ...
Fatemeh Babajani, Hadi Mozafari
wiley   +1 more source

Aerobic Endurance Training Modulates Cardiac Renin‐Angiotensin System Peptides and Matrix Metalloproteinase Activity During Chronic Stress

open access: yesJournal of Cellular and Molecular Medicine, Volume 30, Issue 15, August 2026.
ABSTRACT To investigate the involvement of metalloproteinases (MMPs) in the context of endurance training and their interactions with renin‐angiotensin signalling (RAS) in stress‐induced pathophysiological responses. Trained rats were submitted to 8‐weeks of endurance treadmill training with chronic mild stress (CMS), TS rats, and without CMS (T).
Vinicius Guzzoni   +14 more
wiley   +1 more source

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