Results 51 to 60 of about 27,806 (225)

Promising perspectives for ruminal protection of polyunsaturated fatty acids through polyphenol-oxidase-mediated crosslinking of interfacial protein in emulsions

Animal, 2018
Previously, polyunsaturated fatty acids (PUFA) from linseed oil were effectively protected (>80%) against biohydrogenation through polyphenol-oxidase-mediated protein crosslinking of an emulsion, prepared with polyphenol oxidase (PPO) extract from potato
N. De Neve, B. Vlaeminck, F. Gadeyne, E. Claeys, P. Van der Meeren, V. Fievez   +5 more
doaj   +1 more source

Gelatin Zymography of Major Proteases in Exosomes of Leishmania major Promastigotes

Iranian Journal of Parasitology, 2023
Background: Enzymatic digestion of extra cellular matrix proteins by proteinases of   Leishmania promastigotes is a complex process. Hence, studies on functional proteomics of these enzymes can help select these enzymes as possible vaccine candidates or
Akram Azambakhtiar, Sedigheh Nabian, Mehdi Mohebali, Mohammad Taheri, Ramin Mazaheri Nezhad Fard   +4 more
doaj   +1 more source

The IkB kinase inhibitor nuclear factor-kB essential modulator–binding domain peptide for inhibition of balloon injury-induced neointimal formation [PDF]

, 2009
Objective—The activation of nuclear factor-kB (NF-kB) is a crucial step in the arterial wall’s response to injury. The identification and characterization of the NF-kB essential modulator– binding domain (NBD) peptide, which can block the activation of
Carnuccio, R., De Stefano, D., Di Lauro, M.V., Di Meglio, P., Grassia, G., Ialenti, A., Ianaro, A., Kennedy, S., Maddaluno, M., Maffia, P., Musilli, C., Parenti, A., Parratt, C.A.   +12 more
core   +1 more source

Detection of Functional Matrix Metalloproteinases by Zymography [PDF]

Journal of Visualized Experiments, 2010
Matrix metalloproteinases (MMPs) are zinc-containing endopeptidases. They degrade proteins by cleavage of peptide bonds. More than twenty MMPs have been identified and are separated into six groups based on their structure and substrate specificity (collagenases, gelatinases, membrane type [MT-MMP], stromelysins, matrilysins, and others).
Hu, Xueyou, Beeton, Christine
openaire   +2 more sources

Stochastic Nanoscale Biophysical Cues as a Basis for the Induction of Glioblastoma‐Like Transcriptional Programs in Astrocytes

Advanced Science, EarlyView.
Stochastic nanoscale physical cues induce glioblastoma (GBM)‐associated transcriptional traits in naïve astrocytes leading to spontaneous formation of spheroids. Cells within spheroids express activated‐MMP2 and a differential gene expression pattern involving P53 and NOTCH3, providing evidence for a role for changes in brain topography, as observed in
Laurent Starck, Tobias Butelmann, Sabrina Hogan, Melika Sarem, Bernd Heimrich, Ritwick Sawarkar, Marie‐Françoise Ritz, Gregor Hutter, V. Prasad Shastri   +8 more
wiley   +1 more source

16S rDNA-Based Identification of Novel Superoxide Dismutase Producing Bacteria Isolated from Indonesia

Microbiology Indonesia, 2011
Superoxide dismutase (SOD) has therapeutic importance because of its antioxidant activity and protects cells from reactive oxygen species attack. This research was intended to screen bacteria isolated from Indonesia for producing novel SODs and to ...
ANA INDRAYATI, VALENTINA YURINA, LARAS AJENG PITAYU, DEBBIE SOEFIE RETNONINGRUM   +3 more
doaj   +1 more source

Dysregulated proteolytic cascades in Netherton syndrome: from molecular pathology to preclinical drug testing

The Journal of Pathology, EarlyView.
Abstract Netherton syndrome (NS) is a rare, severe, and often life‐threatening disease for which current therapeutic approaches are limited and show variable effectiveness. NS is characterized by excessive epidermal desquamation that results in a highly defective epidermal barrier, constitutive skin inflammation, allergies, and hair abnormalities.
Eleni Zingkou, Evangelos Bisyris, Georgios Pampalakis, Georgia Sotiropoulou   +3 more
wiley   +1 more source

Early increases in plasminogen activator activity following partial hepatectomy in humans [PDF]

, 2004
Background Increases in urokinase-like plasminogen activator (uPA) activity are reported to be amongst the earliest events occurring in remnant liver following partial hepatectomy in rats, and have been proposed as a key component of the regenerative ...
Bird, N.C., Majeed, A.W., Mangnall, D., Smith, K.   +3 more
core   +2 more sources

Matrix Metalloproteinases in Periodontal and Peri‐Implant Diseases: Contribution to Their Pathogenesis, Diagnosis, and Treatment

Journal of Periodontal Research, EarlyView.
This graphical abstract illustrates the role of matrix metalloproteinases (MMPs) across the pathogenesis, diagnosis, and therapeutics of periodontal and peri‐implant diseases. Microbial and host stimuli trigger MMP activation leading to extracellular matrix breakdown, point‐of‐care aMMP‐8 detection aids diagnosis, and adjunctive or AI‐assisted ...
Timo Sorsa, Lorne M. Golub, Julie Toby Thomas, Pietro Leone, Sukumaran Anil, Veli‐Jukka Uitto   +5 more
wiley   +1 more source

THE ROUND LIGAMENT IN DEVELOPMENTAL HIP DYSPLASIA: ARE ITS MECHANICAL AND HISTOLOGICAL PROPERTIES PRESERVED?

Acta Ortopédica Brasileira, 2022
Introduction During open surgical dislocated hip reduction, several anatomical structures, such as the round ligament, are approached. However, there is controversy over both the possibility of preserving the ligament and its functional importance ...
ALEXANDRE ZUCCON, HAMILTON DA ROSA PEREIRA, SÉRGIO ALEXANDRE ALCÂNTARA DOS SANTOS, SÉRGIO LUÍS FELISBINO, LUÍS ANTÔNIO JUSTULIN JUNIOR, DANIELE CRISTINA CATANEO   +5 more
doaj   +1 more source