Results 61 to 70 of about 7,707 (195)

ChemInform Abstract: “Click” Synthesis of Nonsymmetrical Bis(1,2,3‐triazoles).

ChemInform, 2010
AbstractA wide scope of triazoles and azides can be used and only aromatic azides [cf.
Aizpurua, Jesús M., Azcune, Itxaso, Fratila, Raluca M., Balentová, Eva, Sagartzazu-Aizpurua, Maialen, Miranda, José Ignacio   +5 more
openaire   +5 more sources

Ruthenium‐Catalyzed Azide‐Selenoalkyne Cycloadditions: A Combined Synthetic–Computational Study into Reaction Scope, Mechanism, and Origins of Regioselectivity

Advanced Synthesis &Catalysis, EarlyView.
A ruthenium‐catalyzed azide–alkyne cycloaddition (RuAAC) reaction is reported for the synthesis of selenium‐substituted triazole products. Reaction regioselectivity is dependent on the identity of the non‐selenium substituent of the alkyne, which challenges the perceived understanding of RuAAC regioselectivity.
Frances E. Bugden, Andrew D. Bage, Ashima Bajaj, Bin Wang, Fiona J. Gibson, Henry Stone, Yingjian Xu, Frank De Proft, Mercedes Alonso, Mark D. Greenhalgh   +9 more
wiley   +1 more source

Synthesis and biological evaluation of norfloxacin – 1,2,3-triazole hybrids as antitumor, antibacterial, and antioxidant agents

Results in Chemistry
Six norfloxacin-1,2,3-triazole hybrids(7a-e) were synthesized via click reaction. Norfloxacin-1,2,3-triazole hybrids were screened for anti-cancer activity against different cancer cell lines DLD1, MCF-7, A549 and HDF.
Samir Al-Taweel, Yousef Al-Saraireh, Salah Al-Trawneh, Solhe Alshahateet, Rakan Al- Tarawneh, Wael Zereini, Omar Al-Qaralleh, Ahmed Al-sarayreh, Mohammad Salem Hareedy, Y.M. Abuhalaweh, Amer Hussien Tarawneh   +10 more
doaj   +1 more source

CuAAC-inspired synthesis of 1,2,3-triazole-bridged porphyrin conjugates: an overview

Beilstein Journal of Organic Chemistry, 2023
Among all the available approaches in organic synthesis, the “click chemistry” protocol is very common nowadays to covalently connect two diverse moieties in a single framework. Therefore, this review focuses on the synthesis and photophysical studies of
Dileep Kumar Singh
doaj   +1 more source

Recent Advances in Bioactive Flavonoid Hybrids Linked by 1,2,3-Triazole Ring Obtained by Click Chemistry

Molecules, 2021
As a result of the biological activities of natural flavonoids, several synthetic strategies aiming to obtain analogues with improved potency and/or pharmacokinetic profile have been developed.
Daniela Pereira, Madalena Pinto, Marta Correia-da-Silva, Honorina Cidade   +3 more
doaj   +1 more source

N‐Containing Carbon Materials in Metal‐Free and Non‐Noble Metal Liquid Phase Heterogenous Catalysis

Advanced Synthesis &Catalysis, EarlyView.
Over 100 examples of non‐noble metal supported on N‐containing and metal‐free N‐containing carbon catalysts are discussed. Particular emphasis is put on how different N‐functionalities influence catalyst performance and stability. Preparation procedures are also examined, with a strong focus on how the heat treatment temperature influences N ...
Fulvio Varamo, Anna Katharina Beine
wiley   +1 more source

1,2,3-Triazoles as Amide-bond Surrogates in Peptidomimetics

CHIMIA, 2013
1,2,3-Triazoles represent a class of heterocycles with interesting properties for application in peptide sciences since they closely resemble amide bonds while being stable to enzymatic degradation. These characteristics make 1,2,3-triazoles promising candidates as amide-bond surrogates for the development of novel peptidomimetics with ...
Ibai E. Valverde, Thomas L. Mindt
openaire   +6 more sources

Direct Pd‐Catalyzed Arylation of 1,2,3‐Triazoles. [PDF]

ChemInform, 2007
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Vladimir Gevorgyan, Alexander S. Dudnik, Natalia Chernyak, Stepan Chuprakov   +3 more
openaire   +5 more sources

Electrocatalytic Dehydrogenative Lactonization of Benzylic Alcohols: A Sustainable Access to Phthalides via N‐hydroxyphthalimide Mediation

Advanced Synthesis &Catalysis, EarlyView.
A mild, scalable electrocatalytic method for direct lactonization of benzylic alcohols to phthalides using N‐hydroxyphthalimide as a redox mediator is reported. This metal‐free process proceeds via a phthalimide‐N‐oxyl‐mediated hydrogen atom transfer mechanism, shows broad scope with good to excellent yields, and enables late‐stage functionalizations ...
Pietro Ronco, Antonia Simi, Enrico Lunghi, Emanuele Casali, Giovanni Lenardon, Alessio Porta, Giuseppe Zanoni   +6 more
wiley   +1 more source

Small molecule purine and pseudopurine derivatives: synthesis, cytostatic evaluations and investigation of growth inhibitory effect in non-small cell lung cancer A549

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Novel halogenated purines and pseudopurines with diverse aryl-substituted 1,2,3-triazoles were prepared. While p-(trifluoromethyl)-substituted 1,2,3-triazole in N-9 alkylated purine and 3-deazapurine was critical for strong albeit unselective activity on
Andrea Bistrović, Petra Grbčić, Anja Harej, Mirela Sedić, Sandra Kraljević-Pavelić, Sanja Koštrun, Janez Plavec, Damjan Makuc, Silvana Raić-Malić   +8 more
doaj   +1 more source